country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-146574

Copy Link Print Information

AKR1C3-IN-7

1 Cited Publications

Kundenbewertung

Based on 1 publication(s) in Google Scholar

AKR1C3-IN-7 (Compound 13) is a potent, selective AKR1C3 inhibitor with an IC₅₀ of 0.19 μM. AKR1C3-IN-7 shows antitumor activity.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₄H₂₀N₂O₄
Molecular Weight:400.43

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

AKR1C3-IN-7 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

AKR1C3-IN-7 (Compound 13) is a potent, selective AKR1C3 inhibitor with an IC₅₀ of 0.19 μM. AKR1C3-IN-7 shows antitumor activity^[1].

IC₅₀ & Target

AKR1C3

.19 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
CWR22R	IC₅₀	54.81 μM Compound: 13	Antiproliferative activity against human 22Rv1 cells expressing AKR1C3 assessed as inhibition of cell growth incubated for 72 hrs by SRB assay Antiproliferative activity against human 22Rv1 cells expressing AKR1C3 assessed as inhibition of cell growth incubated for 72 hrs by SRB assay	[PMID: 35447434]

In Vitro

AKR1C3-IN-7 (Compound 13) shows antiproliferative activity with an IC₅₀ of 54.81 ± 2.47 μM against prostate cancer cell line 22rv1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 400.43
Formel C₂₄H₂₀N₂O₄
SMILES

COC1=CC=C(C=C1)CC2=C(C(O)=NO2)C(NC3=CC(C4=CC=CC=C4)=CC=C3)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

All

Sort by:

Journal Impact Factor

J Agric Food Chem

Resveratrol Derivatives with a Urea Backbone Exert Anticancer Effects against Liver Cancer via Apoptosis Induction and Metastasis Inhibition. [Abstract]

2025 Dec 10;73(49):31429-31443. PMID: 41324234

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Pippione AC, et al. New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold. Eur J Med Chem. 2022 Jul 5;237:114366. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

AKR1C3-IN-7

1 Cited Publications

100 mg Angebot einholen

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

AKR1C3-IN-7

Publications Citing Use of MedChemExpress (MCE) AKR1C3-IN-7

Biologische Aktivität

Chemical Information

Publications (1)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

AKR1C3-IN-7 Related Classifications

HY-146574 Related Classifications