AKR1C3-IN-8
AKR1C3-IN-8 (Compound 5) is a potent, selective AKR1C3 inhibitor with an IC50 of 0.069 μM. AKR1C3-IN-8 shows antitumor activity.
For research use only. We do not sell to patients.
- CAS No.: 3034629-37-0
- Formula: C23H20N4O3
- Molecular Weight:400.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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AKR1C3 .069 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CWR22R | IC50 |
52.06 μM
Compound: 5
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Antiproliferative activity against human 22Rv1 cells expressing AKR1C3 assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
Antiproliferative activity against human 22Rv1 cells expressing AKR1C3 assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
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[PMID: 35447434] |
AKR1C3-IN-8 (Compound 5) shows antiproliferative activity with an IC50 of 52.06 ± 0.99 μM against prostate cancer cell line 22rv1[1].
AKR1C3-IN-8 (0-50 μM) inhibits PSA expression and testosterone production on 22RV1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3034629-37-0
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Molecular Weight 400.43
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Formula C23H20N4O3
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SMILES
COC1=CC=C(C=C1)CN2N=NC(O)=C2C(NC3=CC(C4=CC=CC=C4)=CC=C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AKR1C3-IN-8 Related Classifications
HY-146575 Related Classifications
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