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Cat. No.: HY-144749

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AKR1C3-IN-5

AKR1C3-IN-5 (Compound 6e) is a potent inhibitor of AKR1C3. AKR1C3 enzyme is overexpressed in hormone-dependent prostate and breast tumors. AKR1C3-IN-5 derived from drupanin, which exhibits half-maximal inhibitory concentration (IC₅₀) of 9.6 ± 3 μM and selectivity index (SI) of 5.5 against MCF-7 cells.

For research use only. We do not sell to patients.

CAS No.: 2839142-93-5
Formula: C₃₄H₄₄N₂O₇
Molecular Weight:592.72

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

AKR1C3-IN-5 Chemical Structure

CAS No.: 2839142-93-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

AKR1C3

9.6 ± 3 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	47.3 μM Compound: 6e	Antiproliferative activity against human DU-145 cells assessed as cell viability for 72 hrs by MTT assay Antiproliferative activity against human DU-145 cells assessed as cell viability for 72 hrs by MTT assay	[PMID: 34454129]
MCF-10A	CC₅₀	52.2 μM Compound: 6e	Cytotoxicity against human MCF-10A cells assessed as cell viability for 72 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as cell viability for 72 hrs by MTT assay	[PMID: 34454129]
MCF7	IC₅₀	9.6 μM Compound: 6e	Antiproliferative activity against human MCF7 cells assessed as cell viability for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell viability for 72 hrs by MTT assay	[PMID: 34454129]
MDA-MB-231	IC₅₀	80.6 μM Compound: 6e	Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability for 72 hrs by MTT assay	[PMID: 34454129]
PC-3	IC₅₀	34 μM Compound: 6e	Antiproliferative activity against human PC-3 cells assessed as cell viability for 72 hrs by MTT assay Antiproliferative activity against human PC-3 cells assessed as cell viability for 72 hrs by MTT assay	[PMID: 34454129]
PNT2	CC₅₀	36.3 μM Compound: 6e	Cytotoxicity against human PNT2 cells assessed as cell viability for 72 hrs by MTT assay Cytotoxicity against human PNT2 cells assessed as cell viability for 72 hrs by MTT assay	[PMID: 34454129]

Chemical Information

CAS No. 2839142-93-5
Molecular Weight 592.72
Formula C₃₄H₄₄N₂O₇
SMILES

CC(OC1=CC=C(C=C1C/C=C(C)\C)/C=C/C(N[C@H](C(OCC2=CC=CC=C2)=O)CCCCNC(OC(C)(C)C)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Rodrigues DM, et al. Synthesis, antitumor activity and in silico analyses of amino acid derivatives of artepillin C, drupanin and baccharin from green propolis. Bioorg Med Chem. 2021 Oct 1;47:116372. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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