AKR1C3-IN-12
AKR1C3-IN-12 (compound 2j) is an aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC50 of 27 nM. AKR1C3-IN-12 enhances the efficacy of Gemcitabine and Cisplatin in bladder cancer.
For research use only. We do not sell to patients.
- CAS No.: 891075-67-5
- Formula: C17H14N2O3
- Molecular Weight:294.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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AKR1C3 27 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CWR22R | IC50 |
2.4 μM
Compound: 2j
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Antagonistic activity at AR in human 22Rv1 cells assessed as reduction in cell number by CCK8 assay
Antagonistic activity at AR in human 22Rv1 cells assessed as reduction in cell number by CCK8 assay
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[PMID: 32847363] |
Chemical Information
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CAS No. 891075-67-5
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Molecular Weight 294.30
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Formula C17H14N2O3
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SMILES
O=C(C1=CC2=C(OC1=N)C(O)=CC=C2)NC3=CC=C(C)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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