1. Cell Cycle/DNA Damage
  2. DNA Alkylator/Crosslinker
  3. OBI-3424

OBI-3424 (Synonyms: TH-3424)

Cat. No.: HY-124573 Purity: 99.23%
Handling Instructions

OBI-3424 (TH-3424) is a prodrug that is selectively converted by AKR1C3 (aldo-keto reductase 1C3) to a potent DNA-alkylating agent. OBI-3424 can be used for hepatocellular carcinoma, castrate-resistant prostate cancer, and acute lymphoblastic leukemia (ALL) research.

For research use only. We do not sell to patients.

OBI-3424 Chemical Structure

OBI-3424 Chemical Structure

CAS No. : 2097713-68-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 456 In-stock
Estimated Time of Arrival: December 31
Solid or liquid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 456 In-stock
Estimated Time of Arrival: December 31
Solid or liquid
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

OBI-3424 (TH-3424) is a prodrug that is selectively converted by AKR1C3 (aldo-keto reductase 1C3) to a potent DNA-alkylating agent. OBI-3424 can be used for hepatocellular carcinoma, castrate-resistant prostate cancer, and acute lymphoblastic leukemia (ALL) research[1].

In Vitro

OBI-3424 exerts potent cytotoxicity against the H460 lung cancer cell line (IC50 of 4.0 nM). OBI-3424 exhibits potent cytotoxicity, in particular against cell lines derived from T-ALL with high AKR1C3 expression, with IC50 values in the low nM range[1].
OBI-3424 also exerts potent cell killing against ALL PDXs, and the median IC50 values were 60.3 nM for B-ALL, 9.7 nM for T-ALL and 31.5 nM for ETP-ALL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

OBI-3424 (0.5-2.5 mg/kg; i.p.; once weekly; for 3 weeks) treatment induces regressions in PDXs mice and results in prolongation of mouse event-free survival[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NSG mice (20-25 g) bearing patient-derived xenografts (PDX)[1]
Dosage: 0.5 mg/kg, 1 mg/kg, 2.5 mg/kg
Administration: Intraperitoneal injection; once weekly; for 3 weeks
Result: Resulted in prolongation of mouse event-free survival.
Clinical Trial
Molecular Weight

460.42

Formula

C₂₁H₂₅N₄O₆P

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (108.60 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1719 mL 10.8596 mL 21.7193 mL
5 mM 0.4344 mL 2.1719 mL 4.3439 mL
10 mM 0.2172 mL 1.0860 mL 2.1719 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (10.86 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.43 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.43 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.23%

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Product Name:
OBI-3424
Cat. No.:
HY-124573
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