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Betulinic acid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (1) Apoptosis (5) Autophagy (3) Bacterial (2) Biochemical Assay Reagents (1) Drug Derivative (7) Drug Isomer (1) Endogenous Metabolite (3) G protein-coupled Bile Acid Receptor 1 (1) HIV (4) Isotope-Labeled Compounds (1) Mitophagy (3) NF-κB (3) Parasite (4) Reference Standards (2) ROR (1) Topoisomerase (3)
By Research Areas:	Cancer (12) Cardiovascular Disease (1) Infection (7) Inflammation/Immunology (5) Metabolic Disease (2) Neurological Disease (1)

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10529

Betulinic acid 30+ Cited Publications Lupatic acid; Betulic acid	Apoptosis Topoisomerase HIV Autophagy Mitophagy NF-κB Endogenous Metabolite Parasite	Infection Neurological Disease Inflammation/Immunology Cancer
Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC₅₀ of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties . Betulinic acid can cross the blood-brain barrier .

HY-N0084

Betulinaldehyde 5 Publications Verification Betulinic aldehyde; Betunal	Bacterial	Infection Cardiovascular Disease Cancer
Betulinaldehyde (Betunal) Has anti-cancer and anti-staphylococcus aureus activity. Betulinaldehyde Suppressible Akt, MAPK sum STAT3 Signal path, increase self-transfer, Suppression A549 Cellular vitality, increase and transfer. Betulinaldehyde suppresses PLCγ1/Ca ²⁺/MMP9 signal pathway, has a key effect on vascular plasticity, and is available for cardiovascular disease (CVD) research.

HY-41121

Boc-L-Ala-OH 1 Publications Verification Boc-Ala-OH	Amino Acid Derivatives	Cancer
Boc-L-Ala-OH (Boc-Ala-OH) is a single N-protected amino acid ligand and a protected L-alanine derivative. Boc-L-Ala-OH promotes Pd (II)-catalyzed enantioselective C-H alkenylation and kinetic resolution. Boc-L-Ala-OH serves as a coupling reagent for the synthesis of liver-targeted glycogen phosphorylase inhibitors and P6A metabolites, and also acts as a negative control in synthesis studies of betulinic acid amino acid esters. Boc-L-Ala-OH is applicable to research on epidermoid squamous cell carcinoma .

HY-10529R

Betulinic acid (Standard) Lupatic acid (Standard); Betulic acid (Standard)	Reference Standards Apoptosis Topoisomerase HIV Autophagy Mitophagy NF-κB Endogenous Metabolite Parasite	Infection Inflammation/Immunology Cancer
Betulinic acid (Standard) is the analytical standard of Betulinic acid. This product is intended for research and analytical applications. Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties . Betulinic acid can cross the blood-brain barrier.

HY-N6587

Betulinic acid methyl ester Methyl betulinate	Parasite	Others
Betulinic acid methyl ester, a betulinic acid derivative, possesses antiprotozoal activity .

HY-W744739

Betulinic acid-d3 Lupatic acid-d₃; Betulic acid-d₃	Isotope-Labeled Compounds Apoptosis Topoisomerase HIV Autophagy Mitophagy NF-κB Endogenous Metabolite Parasite	Infection Inflammation/Immunology Cancer
Betulinic acid-d₃ (Lupatic acid-d₃) is a deuterium labeled Betulinic acid (HY-10529). Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC₅₀ of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties . Betulinic acid can cross the blood-brain barrier.

HY-N3361

(3β,4α)-Lup-20(29)-ene-3,23-diol	Others	Cancer
(3β,4α)-Lup-20(29)-ene-3,23-diol (compound 11) is a natural lupane-type triterpenes betulinic acid with anti-tumor activity .

HY-101597

NVX-207	Apoptosis	Cancer
NVX-207, a Betulinic acid-derived anti-cancer compound, shows anti-tumor activity (mean IC₅₀=3.5 μM) against various human and canine cell lines. NVX-207-induced apoptosis is associated with activation of the intrinsic apoptotic pathway via cleavage of caspases -9, -3, -7 and of PARP .

HY-N9857

Betulinic acid palmitate	Others	Others
Betulinic acid palmitate is a natural product .

HY-149547

DRF-4015	Drug Derivative	Cancer
DRF-4015 (Compound 22) is a betulinic acid derivative with antitumor activity .

HY-155542

RORγ antagonist 1	ROR	Cancer
RORγ antagonist 1 (compound 22), a potent betulinic acid derivative, is an antagonist of RORγ (K_D=0.18 μM). RORγ antagonist 1 exhibits anti-proliferative activity in HPAF-II pancreatic cancer xenograft model. RORγ antagonist 1 inhibits RAS/MAPK and AKT/mTORC1 pathway, and induces caspase-dependent apoptosis in pancreatic cancer cells .

HY-115720

Betulinic acid derivative-1	Drug Derivative	Inflammation/Immunology
Betulinic acid derivative-1 exhibits distinguished activities on inhibiting osteoclast (OC) differentiation with an IC₅₀ value of 1.86 μM.

HY-N9477

Betulinic aldehyde oxime Betulin-28-oxime	Drug Derivative Bacterial	Infection
Betulinic aldehyde oxime (Compound 31) is a betulin (HY-N0083) derivative that has antimicrobial properties against E. aerogenes, E. coli, E. faecalis, P. aeruginosa, S. aureus, and C. albicans. Betulinic aldehyde oxime displays cytotoxicity towards hepatocytes, with an IC₅₀ of 25 μM .

HY-146338

RPR103611	HIV	Infection
RPR103611, the betulinic acid derivative, is a potent HIV-1 entry inhibitor with IC₅₀s of 80, 0.27, and 0.17 for CCR5-tropic virus YU2, CXCR4-tropic virus NL4-3 and dual tropic virus 89.6, respectively .

HY-169479

Betulinic glycine amide	Drug Derivative	Infection Cancer
Betulinic glycine amide (compound 5a) is a pentacyclic triterpenoid and derivative of Betulinic acid (HY-10529). Betulinic glycine amide has been used as a precursor in the synthesis of betulinic acid derivatives with anticancer and antiviral activity .

HY-186162

Betulinic acid-OBn	Drug Derivative	Others
Betulinic acid-OBn is a derivative of Betulinic acid (HY-10529) .

HY-186162A

*(R)-Betulinic* acid-OBn**	Drug Isomer	Others
(R)-Betulinic acid-OBn is an isomer of Betulinic acid-OBn(HY-186162) .

HY-177050

RG-239	G protein-coupled Bile Acid Receptor 1	Metabolic Disease Inflammation/Immunology
RG-239 is an orally active TGR5 agonist with an EC₅₀ of 120 nM, significantly outperforming Betulinic acid (HY-10529) (EC₅₀ = 1.04 μM). RG-239 demonstrates higher selectivity for TGR5 compared to the FXRα. RG-239 increases mitochondrial activity in adipocytes and promotes neurite outgrowth at higher concentrations. RG-239 inhibits LPS (HY-D1056)-induced iNOS expression and nitrite production in Raw264.7 and microglia cells. RG-239 can be used for the study of type 2 diabetes ^{[1][2][3][4][5]}.

HY-N18345A

Paliurusene A	Drug Derivative	Cancer
Paliurusene A is a betulinic acid-type pentacyclic triterpenoid that can be isolated from the leaves of Paliurus ramosissimus (Lour.) Poir. Paliurusene A induces growth inhibition of human hepatoma cells in vitro. Paliurusene A is applicable to research related to liver cancer .

HY-E71272

β-Amyrin 28-monooxygenase	Biochemical Assay Reagents	Others
β-Amyrin 28-monooxygenase (EC 1.14.13.201), found in plants, is involved in the biosynthesis of oleanane-type triterpenoids, such as ginsenoside Ro. The enzyme from Medicago trunculata (CYP716A12) can also convert α-amyrin and lupeol to ursolic acid and betulinic acid, respectively.

HY-101597R

NVX-207 (Standard)	Reference Standards Apoptosis	Cancer
NVX-207 (Standard) is the analytical standard of NVX-207 (HY-101597). This product is intended for research and analytical applications. NVX-207, a Betulinic acid-derived anti-cancer compound, shows anti-tumor activity (mean IC50=3.5 μM) against various human and canine cell lines. NVX-207-induced apoptosis is associated with activation of the intrinsic apoptotic pathway via cleavage of caspases -9, -3, -7 and of PARP .

HY-178355

Anti-osteoporosis agent-12	Drug Derivative	Metabolic Disease
Anti-osteoporosis agent-12 (Compound 18) is an orally active pyrazole-fused betulinic acid derivative with potent anti-osteoporosis activity. Anti-osteoporosis agent-12 exhibits a strong inhibitory effect on RANKL-induced osteoclastogenesis in RAW264.7 cells, with an IC₅₀ of 7.96 nM. Anti-osteoporosis agent-12 can dose-dependently improve key micro-CT parameters of bone, reduce the level of serum bone resorption marker (CTx), and effectively prevent ovariectomy-induced bone loss. Anti-osteoporosis agent can be used for the study of osteoporosis .

Cat. No.	Product Name	Target	Research Area

HY-41121

Boc-L-Ala-OH 1 Publications Verification Boc-Ala-OH	Amino Acid Derivatives	Cancer
Boc-L-Ala-OH (Boc-Ala-OH) is a single N-protected amino acid ligand and a protected L-alanine derivative. Boc-L-Ala-OH promotes Pd (II)-catalyzed enantioselective C-H alkenylation and kinetic resolution. Boc-L-Ala-OH serves as a coupling reagent for the synthesis of liver-targeted glycogen phosphorylase inhibitors and P6A metabolites, and also acts as a negative control in synthesis studies of betulinic acid amino acid esters. Boc-L-Ala-OH is applicable to research on epidermoid squamous cell carcinoma .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-10529

Betulinic acid 30+ Cited Publications Lupatic acid; Betulic acid	Infection Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis Topoisomerase HIV Autophagy Mitophagy NF-κB Endogenous Metabolite Parasite
Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC₅₀ of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties . Betulinic acid can cross the blood-brain barrier .

HY-N0084

Betulinaldehyde 5 Publications Verification Betulinic aldehyde; Betunal	Triterpenes other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification Cancer	Bacterial
Betulinaldehyde (Betunal) Has anti-cancer and anti-staphylococcus aureus activity. Betulinaldehyde Suppressible Akt, MAPK sum STAT3 Signal path, increase self-transfer, Suppression A549 Cellular vitality, increase and transfer. Betulinaldehyde suppresses PLCγ1/Ca ²⁺/MMP9 signal pathway, has a key effect on vascular plasticity, and is available for cardiovascular disease (CVD) research.

HY-10529R

Betulinic acid (Standard) Lupatic acid (Standard); Betulic acid (Standard)	Triterpenes Structural Classification other families Terpenoids Plants Endogenous metabolite Source Classification	Reference Standards Apoptosis Topoisomerase HIV Autophagy Mitophagy NF-κB Endogenous Metabolite Parasite
Betulinic acid (Standard) is the analytical standard of Betulinic acid. This product is intended for research and analytical applications. Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties . Betulinic acid can cross the blood-brain barrier.

HY-N6587

Betulinic acid methyl ester Methyl betulinate	Triterpenes other families Classification of Application Fields Terpenoids Other Diseases Plants Disease Research Fields Source Classification	Parasite
Betulinic acid methyl ester, a betulinic acid derivative, possesses antiprotozoal activity .

HY-N3361

(3β,4α)-Lup-20(29)-ene-3,23-diol	Triterpenes Terpenoids Bursera simaruba (L.) Sarg. Plants Burseraceae Source Classification	Others
(3β,4α)-Lup-20(29)-ene-3,23-diol (compound 11) is a natural lupane-type triterpenes betulinic acid with anti-tumor activity .

HY-N9857

Betulinic acid palmitate	Triterpenes Terpenoids Betula platyphylla Sukaczev Plants Betulaceae Source Classification	Others
Betulinic acid palmitate is a natural product .

HY-N9477

Betulinic aldehyde oxime Betulin-28-oxime	Triterpenes Terpenoids Betula platyphylla Sukaczev Plants Betulaceae Source Classification	Drug Derivative Bacterial
Betulinic aldehyde oxime (Compound 31) is a betulin (HY-N0083) derivative that has antimicrobial properties against E. aerogenes, E. coli, E. faecalis, P. aeruginosa, S. aureus, and C. albicans. Betulinic aldehyde oxime displays cytotoxicity towards hepatocytes, with an IC₅₀ of 25 μM .

HY-N18345A

Paliurusene A	Structural Classification Terpenoids Aconitum jaluense Kom. Plants Rhamnaceae Pentacyclic Triterpenoids Source Classification	Drug Derivative
Paliurusene A is a betulinic acid-type pentacyclic triterpenoid that can be isolated from the leaves of Paliurus ramosissimus (Lour.) Poir. Paliurusene A induces growth inhibition of human hepatoma cells in vitro. Paliurusene A is applicable to research related to liver cancer .

Cat. No.	Product Name	Chemical Structure

HY-W744739

Betulinic acid-d3
Betulinic acid-d₃ (Lupatic acid-d₃) is a deuterium labeled Betulinic acid (HY-10529). Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC₅₀ of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties . Betulinic acid can cross the blood-brain barrier.

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Betulinic acid

Inhibitors & Agonists

Peptides

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Isotope-Labeled Compounds

Natural
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