DRF-4015
Based on 1 Customer Validation
DRF-4015 (Compound 22) is a betulinic acid derivative with antitumor activity.
For research use only. We do not sell to patients.
- Purity : 95.28%
- CAS No.: 905838-14-4
- Formula: C38H52N2O3
- Molecular Weight:584.83
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
3.53 μg/mL
Compound: 38
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Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
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[PMID: 18752941] |
| DU-145 | IC50 |
7 μg/mL
Compound: 38
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Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
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[PMID: 18752941] |
| HBL-100 | IC50 |
>20 μg/mL
Compound: 38
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Cytotoxicity against human HBL100 cells after 72 hrs by MTT assay
Cytotoxicity against human HBL100 cells after 72 hrs by MTT assay
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[PMID: 18752941] |
| K562 | IC50 |
11.92 μg/mL
Compound: 38
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Cytotoxicity against human K-562 cells after 72 hrs by MTT assay
Cytotoxicity against human K-562 cells after 72 hrs by MTT assay
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[PMID: 18752941] |
| MIA PaCa-2 | IC50 |
0.67 μg/mL
Compound: 38
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Cytotoxicity against human MIA PaCa2 cells after 72 hrs by MTT assay
Cytotoxicity against human MIA PaCa2 cells after 72 hrs by MTT assay
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[PMID: 18752941] |
| NIH3T3 | IC50 |
0.68 μg/mL
Compound: 38
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Cytotoxicity against mouse NIH3T3 cells after 72 hrs by MTT assay
Cytotoxicity against mouse NIH3T3 cells after 72 hrs by MTT assay
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[PMID: 18752941] |
| PA-1 | IC50 |
3 μg/mL
Compound: 38
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Cytotoxicity against human PA-1 cells after 72 hrs by MTT assay
Cytotoxicity against human PA-1 cells after 72 hrs by MTT assay
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[PMID: 18752941] |
| SW-620 | IC50 |
8.7 μg/mL
Compound: 38
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Cytotoxicity against human SW620 cells after 72 hrs by MTT assay
Cytotoxicity against human SW620 cells after 72 hrs by MTT assay
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[PMID: 18752941] |
Chemical Information
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CAS No. 905838-14-4
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Appearance Solid
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Molecular Weight 584.83
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Formula C38H52N2O3
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Color Light yellow to yellow
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SMILES
OC(CNC([C@]12[C@@]([C@@H](CC2)C(C)=C)([H])[C@]3([H])[C@@](CC1)([C@]4([C@]([C@@]5([C@@](C(C)(C6=C(C7=CC=CC=C7N6)C5)C)([H])CC4)C)([H])CC3)C)C)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Protocols
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Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DRF-4015 Related Classifications
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