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Cat. No.: HY-115720

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Betulinic acid derivative-1

Betulinic acid derivative-1 exhibits distinguished activities on inhibiting osteoclast (OC) differentiation with an IC₅₀ value of 1.86 μM.

For research use only. We do not sell to patients.

CAS No.: 2708127-92-6
Formula: C₃₇H₆₀N₄
Molecular Weight:560.90

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Betulinic acid derivative-1 Chemical Structure

CAS No.: 2708127-92-6

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

Betulinic acid derivative-1 exhibits distinguished activities on inhibiting osteoclast (OC) differentiation with an IC₅₀ value of 1.86 μM.

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	CC₅₀	16.18 μM Compound: 25	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 34491054]
RAW264.7	CC₅₀	5.77 μM Compound: 25	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured for 96 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured for 96 hrs by MTT assay	[PMID: 34491054]
RAW264.7	IC₅₀	1.86 μM Compound: 25	Inhibition of RANKL/M-CSF-induced osteoclastogenesis in mouse RAW264.7 cells measured for 4 days by TRAP staining based assay Inhibition of RANKL/M-CSF-induced osteoclastogenesis in mouse RAW264.7 cells measured for 4 days by TRAP staining based assay	[PMID: 34491054]
RAW264.7	IC₅₀	2.32 μM Compound: 25	Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as reduction in IL-1beta production incubated for 48 hrs by ELISA analysis Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as reduction in IL-1beta production incubated for 48 hrs by ELISA analysis	[PMID: 34491054]
RAW264.7	IC₅₀	21.41 μM Compound: 25	Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as reduction in TNF-alpha production incubated for 48 hrs by ELISA analysis Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as reduction in TNF-alpha production incubated for 48 hrs by ELISA analysis	[PMID: 34491054]
RAW264.7	IC₅₀	8.1 μM Compound: 25	Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as reduction in IL-6 production incubated for 48 hrs by ELISA analysis Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as reduction in IL-6 production incubated for 48 hrs by ELISA analysis	[PMID: 34491054]

Chemical Information

CAS No. 2708127-92-6
Molecular Weight 560.90
Formula C₃₇H₆₀N₄
SMILES

CN(CC1)CCC1CN[C@]23[C@@]([C@@H](CC3)C(C)=C)([H])[C@]4([H])[C@@](CC2)([C@]5([C@]([C@@]6([C@@](C(C)(C7=NNC=C7C6)C)([H])CC5)C)([H])CC4)C)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang J, et al. Synthesis and Biological Evaluation of C-17-Amino-Substituted Pyrazole-Fused Betulinic Acid Derivatives as Novel Agents for Osteoarthritis Treatment. J Med Chem. 2021 Sep 23;64(18):13676-13692. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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