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  4. Betulinic glycine amide

Betulinic glycine amide (compound 5a) is a pentacyclic triterpenoid and derivative of Betulinic acid (HY-10529). Betulinic glycine amide has been used as a precursor in the synthesis of betulinic acid derivatives with anticancer and antiviral activity.

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Betulinic glycine amide

Betulinic glycine amide Chemical Structure

CAS No. : 174740-40-0

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Based on 1 publication(s) in Google Scholar

Betulinic glycine amide Related Antibodies

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Description

Betulinic glycine amide (compound 5a) is a pentacyclic triterpenoid and derivative of Betulinic acid (HY-10529). Betulinic glycine amide has been used as a precursor in the synthesis of betulinic acid derivatives with anticancer and antiviral activity[1].

Cellular Effect
Cell Line Type Value Description References
CHO EC50
> 10 μM
Compound: 33
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
[PMID: 19911773]
KB ED50
> 20 μg/mL
Compound: 16
In vitro cytotoxicity (antitumor activity) against human epidermoid carcinoma of mouth cell line (KB)
In vitro cytotoxicity (antitumor activity) against human epidermoid carcinoma of mouth cell line (KB)
[PMID: 10328313]
SK-MEL-2 ED50
4.2 μg/mL
Compound: 16
In vitro cytotoxicity (antitumor activity) against human melanoma (MEL-2) cell lines
In vitro cytotoxicity (antitumor activity) against human melanoma (MEL-2) cell lines
[PMID: 10328313]
Molecular Weight

513.75

Formula

C32H51NO4
CAS No.
SMILES

OC(CNC([C@]12[C@@]([C@@H](CC2)C(C)=C)([H])[C@]3([H])[C@@](CC1)([C@]4([C@]([C@@]5([C@@](C(C)([C@H](CC5)O)C)([H])CC4)C)([H])CC3)C)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Betulinic glycine amide Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Betulinic glycine amide174740-40-0Drug DerivativeDrug derivativeInhibitorinhibitorinhibit

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Betulinic glycine amide
Cat. No.:
HY-169479
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