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Pathways Recommended: Stem Cell/Wnt Cell Cycle/DNA Damage
Results for "

CCRF-CEM leukemia cells

" in MedChemExpress (MCE) Product Catalog:

16

Inhibitors & Agonists

6

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N3434
    Kaempferol 3,7,4'-trimethyl ether

    		Drug Derivative Reactive Oxygen Species (ROS) Cancer
    Kaempferol 3,7,4'-trimethyl ether is an O-methylated kaempferol flavonol aglycone distributed in Siparuna gigantotepala, Aframomum arundinaceum and Siparuna guianensis. Kaempferol 3,7,4'-trimethyl ether exhibits antioxidant activity. Kaempferol 3,7,4'-trimethyl ether suppresses the proliferation of leukemia cells and exerts selective cytotoxicity against both drug‑sensitive and multi‑factorial drug‑resistant cancer cells. Kaempferol 3,7,4'-trimethyl ether can be applied in the research of multidrug‑resistant cancers .
    Kaempferol 3,7,4'-trimethyl ether
  • HY-137129
    10-Formyl-7,8-dihydrofolic acid

    		Dihydrofolate reductase (DHFR) Cancer
    10-Formyl-7,8-dihydrofolic acid is a biologically active folic acid and growth promoter. 10-Formyl-7,8-dihydrofolic acid serves as a substrate for aminoimidazolecarboxamide ribonucleotide transformylase and dihydrofolate reductase (DHFR) to support catalytic reactions (with detection wavelengths of 552 nm and 340 nm, respectively). 10-Formyl-7,8-dihydrofolic acid not only promotes the growth of leukemia cells, but also effectively reverses the growth inhibition induced by antifolate drugs under folate-deficient conditions. 10-Formyl-7,8-dihydrofolic acid can be used in the research of leukemia .
    10-Formyl-7,8-dihydrofolic acid
  • HY-136650A
    Fludarabine triphosphate trisodium
    1 Publications Verification

    F-ara-ATP trisodium

    		 Nucleoside Antimetabolite/Analog Drug Metabolite DNA/RNA Synthesis Apoptosis Cancer
    Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 μM and a Ki of 6.1 μM. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis .
    Fludarabine triphosphate trisodium
  • HY-162753
    ZW-1226

    		P-glycoprotein Cancer
    ZW-1226 is a dual Tyrosyl DNA phosphodiesterase 2 (TDP2) and Multidrug resistance-associated protein 1 (MRP1) inhibitor with IC50 values of 0.2 and 0.5 μM, respectively. ZW-1226 exhibits selectivity over other ABC transporters. ZW-1226 elevates intracellular GSH levels, and reverses MRP1-mediated drug resistance. ZW-1226 can be used for the research of leukemia, non-small-cell lung cancer, and multidrug resistant small-cell lung cancer .
    ZW-1226
  • HY-169021
    JNK-1-IN-3

    		JNK Cancer
    JNK-1-IN-3 (Compound 9e) is an inhibitor of JNK1 that downregulates JNK1 gene expression and inhibits the protein levels of its phosphorylated form, concurrently reducing the expression of its downstream targets, c-Jun and c-Fos, in tumors while restoring p53 activity. JNK-1-IN-3 exhibits broad-spectrum antiproliferative activity, particularly with high inhibitory activity against renal and breast cancer cell lines, demonstrating both in vivo and in vitro anticancer activity .
    JNK-1-IN-3
  • HY-N8386
    Berkeleylactone F

    		Antibiotic Infection Cancer
    Berkeleylactone F is an antibiotic macrolide compound. Berkeleylactone F showed modest inhibition of CCRF-CEM leukemia cells .
    Berkeleylactone F
  • HY-136650
    Fludarabine triphosphate

    F-ara-ATP

    		 Nucleoside Antimetabolite/Analog Drug Metabolite DNA/RNA Synthesis Apoptosis Cancer
    Fludarabine triphosphate (F-ara-ATP), the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 μM and a Ki of 6.1 μM. Fludarabine triphosphate inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis .
    Fludarabine triphosphate
  • HY-178940
    Apoptosis inducer 49

    		Apoptosis Checkpoint Kinase (Chk) CDK DNA/RNA Synthesis Bcl-2 Family Caspase Cancer
    Apoptosis inducer 49 is a selective apoptosis inducer with high specificity against CCRF-CEM leukemia cells (IC50 = 2.68 μM). Apoptosis inducer 49 enhances RNA synthesis and replication stress, activates the Chk1-p21 axis, leading to S-phase arrest. Apoptosis inducer 49 can inhibit Bcl-2 and activate caspase-3. Apoptosis inducer 49 can be used for the study of Leukemia .
    Apoptosis inducer 49
  • HY-157464
    [Ru(phen)2(4-Me-Sal)]BF4

    		Drug Derivative Cancer
    [Ru(phen)2(4-Me-Sal)]BF4 (compound 10), a Ru(II)-based polypyridyl complexe, displays outstanding antiproliferative activity against drug-sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cells (IC50=0.52 μM and 5.56 μM, respectively) .
    [Ru(phen)2(4-Me-Sal)]BF4
  • HY-N16507
    Bruceoside D

    		Microtubule/Tubulin Cancer
    Bruceoside D is a cytotoxic quassinoid glucoside found in Brucea javanica. Bruceoside D is a microtubule polymerization inhibitor. Bruceoside D demonstrates inhibitory activity against leukemia (CCRF-CEM), non-small cell lung cancer (A549), and ovarian cancer (OVCAR-3) cell lines. Bruceoside D is promising for research of cancers .
    Bruceoside D
  • HY-147901
    KDM1/CDK1-IN-1

    		Histone Demethylase CDK Apoptosis Caspase Cancer
    KDM1/CDK1-IN-1 (compound 4) is a potent KDM1 and CDK1 inhibitor, with IC50 values of 0.096 and 0.078 μM, respectively.KDM1/CDK1-IN-1 induces cell cycle arrest at G2/M phase and apoptosis in HOP-92 cells. KDM1/CDK1-IN-1 exhibits potent cytotoxic activity against the CCRF-CEM, HOP-92 and Hep-G2 cells, with IC50 values of 16.34, 3.45 and 7.79 μM, respectively .
    KDM1/CDK1-IN-1
  • HY-117007
    Glycidyl methacrylate

    		Apoptosis Others
    Glycidyl methacrylate exhibits concentration-dependent cytotoxicity and genotoxicity against human peripheral blood lymphocytes and CCRF-CEM leukemia cells. Glycidyl methacrylate can induce DNA strand breaks, base oxidative damage, and apoptosis through oxidative stress mechanisms, but the induced DNA damage can be effectively cleared by the cellular repair system within 2 hours (>90%). Glycidyl methacrylate can be used in dental composite restorative materials .
    Glycidyl methacrylate
  • HY-N17604
    (6aR,11aR)-Edunol

    		Drug Derivative Cancer
    (6aR,11aR)-Edunol (compound 10) is a pterocarpan and antiproliferative agent. (6aR,11aR)-Edunol can be found in the roots of Lonchocarpus bussei and the stem bark of Lonchocarpus eriocalyx. (6aR,11aR)-Edunol exerts antiproliferative effects against drug-sensitive leukemia cells and multidrug-resistant leukemia cells. (6aR,11aR)-Edunol can be used for the research of leukemia .
    (6aR,11aR)-Edunol
  • HY-181710
    LASSBio-2337

    		mTOR PI3K Cancer
    LASSBio-2337 is a dual pan-PI3K/mTOR inhibitor with an mTOR IC50 of 5.8 μM.LASSBio-2337 functionally modulates mTOR and all PI3K isoforms.LASSBio-2337 acts as a cytotoxic agent in leukemia cells, including multidrug-resistant populations.LASSBio-2337 spares nontumor human peripheral blood mononuclear cells.LASSBio-2337 displays moderate PAMPA-GIT permeability.LASSBio-2337 shows low metabolic stability in rat liver microsomes.LASSBio-2337 is aqueous insoluble.LASSBio-2337 can be used for the research of acute lymphoblastic leukemia, chronic myelogenous leukemia, breast cancer .
    LASSBio-2337
  • HY-N17588
    9-O-Angeloyl-8-methoxythymol

    		Others Cancer
    9-O-Angeloyl-8-methoxythymol is a thymol derivative and cytotoxin, with a IC50 value of 13.1 μg/mL against human myeloid leukemia cells, a IC50 value of 31.8 μg/mL against human lymphoblastic leukemia cells, and a IC50 >40 μg/mL against colon cancer and lymphoma cells. 9-O-Angeloyl-8-methoxythymol is applicable to leukemia-related research .
    9-O-Angeloyl-8-methoxythymol
  • HY-106021
    Tasidotin

    ILX651 free base

    		 Microtubule/Tubulin Prolyl Endopeptidase (PREP) Cancer
    Tasidotin (ILX651 free base) is a tubulin inhibitor and competitive Prolyl Endopeptidase (PREP) inhibitor, with an IC50 of 10 μM against bovine tubulin. Tasidotin exhibits high cerebrospinal fluid penetration in non-human primates. Tasidotin antagonizes microtubule assembly and induces an extended assembly lag phase, thereby inhibiting mitosis and cell proliferation, and exerts cytotoxic and oncolytic effects on cancer cells. Tasidotin is metabolized into polypeptides and proline inside cells, and its in vivo metabolism is mediated by prolyl endopeptidase. Tasidotin can be applied in research related to Burkitt's lymphoma, breast cancer, leukemia, melanoma, central nervous system malignancies and various solid tumors .
    Tasidotin

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