Caspase-3-IN-1

By Targets:	Caspase (12) Akt (1) Amyloid-β (1) Antibiotic (2) Apoptosis (8) Autophagy (2) Bacterial (2) Bcl-2 Family (2) CDK (1) Flavivirus (1) Fluorescent Dye (2) HDAC (1) HIV (1) Interleukin Related (1) P-glycoprotein (1) p38 MAPK (1) PARP (2) PKC (1) Pyroptosis (2) RABV (1) VEGFR (1)
By Research Areas:	Cancer (13) Infection (5) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (2)

Targets Recommended: Caspase AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136975

Caspase-3-IN-1

Caspase Neurological Disease Metabolic Disease

Caspase-3-IN-1 (compound 11b) is a potent Caspase-3 inhibitor, with an IC₅₀ of 14.5 nM .
HY-P2614

Mca-DEVDAP-K(Dnp)-OH

Caspase Others

Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for caspase-3 .
HY-W792412

Z-YVAD-CMK

Caspase Cancer

Z-YVAD-CMK is a caspase-1 and caspase-3 inhibitor .
HY-P5936

Ac-AAVALLPAVLLALLAP-DEVD-CHO

DEVD-CHO-CPP 32
Caspase Cancer

Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) is a potent and reversible caspase-3 inhibitor .

*Caspase-3-IN-1*	Caspase	Neurological Disease Metabolic Disease
Caspase-3-IN-1 (compound 11b) is a potent *Caspase-3* inhibitor, with an IC₅₀ of 14.5 nM .

Mca-DEVDAP-K(Dnp)-OH	Caspase	Others
Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for *caspase-3* .

Z-YVAD-CMK	Caspase	Cancer
Z-YVAD-CMK is a *caspase-1* and *caspase-3* inhibitor .

Ac-AAVALLPAVLLALLAP-DEVD-CHO DEVD-CHO-CPP 32	Caspase	Cancer
Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) is a potent and reversible *caspase-3* inhibitor .

HY-156154

*Caspase-3 activator 1*	Pyroptosis	Cancer
Caspase-3 activator 1 (compound 4b) is a Ru(III) metal complex that inhibits gastric tumor growth and metastasis. Caspase-3 activator 1 mediates caspase-3 cleavage, which in turn causes Caspase-3 to cleave gasdermin E (GSDME) to produce the GSDME-N terminus, causing gastric tumor cell membrane perforation. Caspase-3 activator 1 is capable of inducing pyroptosis and pyroptosis-induced immune responses and can be assembled with decitabine DCT (HY-A0004) into a 4b-DCT-Lip lipid delivery system .

HY-P3475

Mca-VDQMDGW-K(Dnp)-NH2

Fluorescent Dye Others

Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .

Mca-VDQMDGW-K(Dnp)-NH2	Fluorescent Dye	Others
Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .

HY-15503

PHA-690509	Caspase CDK Flavivirus	Infection
PHA-690509 is an anti-ZikV compound that inhibits ZikV replication. PHA-690509 is also a CDK inhibitor, and inhibits *caspase-3* activity .

HY-P2228

Chlamydocin	HDAC Apoptosis	Cancer
Chlamydocin, a fungal metabolite, is a highly potent HDAC inhibitor, with an IC₅₀ of 1.3 nM. Chlamydocin exhibits potent antiproliferative and anticancer activities. Chlamydocin induces apoptosis by activating caspase-3 .

HY-146548

Anticancer agent 43	Apoptosis Bcl-2 Family Caspase PARP	Cancer
Anticancer Agent 43 is a potent anticancer agent. Anticancer Agent 43 induces apoptosis by caspase 3, PARP1, and Bax dependent mechanisms. Anticancer Agent 43 induces DNA damage .

HY-137371

Lactonic sophorolipid	Bacterial Apoptosis Antibiotic	Infection Cancer
Lactonic sophorolipid is a natural antimicrobial surfactant for oral hygiene . Lactonic sophorolipid, a potential anticancer agent, induces apoptosis in human HepG2 cells through the caspase-3 pathway .

HY-N6681

15-Acetoxyscirpenol	Caspase Bacterial Apoptosis Antibiotic	Infection
15-acetoxyscirpenol, one of acetoxyscirpenol moiety mycotoxins (ASMs), strongly induces apoptosis and inhibits Jurkat T cell growth in a dose-dependent manner by activating other *caspases* independent of caspase-3 .

HY-N12503

Patuletin	Apoptosis Caspase	Cancer
Patuletin is a flavonol, that can be isolated from the flowers of Tagetes patula. Patuletin shows anti-proliferative activity against cancer cells. Patuletin causes significant nuclear fragmentation and has a great capacity to induce *caspase-3* activation .

HY-N7930

Crenulatin	Others	Others
Crenulatin is a gallotannin that can be isolated from Rhodiola rosea. Crenulatin can be used as a biomarker to identify potentially adulterated R. rosea products. Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, via regulating Fas/Bcl-2 expression and caspase-3 activity .

HY-144604

FPR2 agonist 2	Others	Infection Neurological Disease
FPR2 agonist 2 is a potent and permeates the blood−brain barrier FPR2 agonist with an EC₅₀ of 0.13 µM, 1.1 µM for FPR2 and FPR1, respectively. FPR2 agonist 2 inhibits the production of pro-inflammatory cytokines, counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity .

HY-157546

VEGFR-2-IN-40	VEGFR Interleukin Related Caspase	Inflammation/Immunology Cancer
VEGFR-2-IN-40 is a VEGFR-2 inhibitor. VEGFR-2-IN-40 boosts early and late apoptosis. VEGFR-2-IN-40 decreases the levels immunomodulatory proteins TNF-α and IL-6 while showing a four-fold rise in an apoptotic marker *caspase-3* .

HY-111675

Ac-FLTD-CMK 4 Publications Verification	Caspase Pyroptosis	Inflammation/Immunology
Ac-FLTD-CMK, a gasdermin D (GSDMD)-derived inhibitor, is a specific inflammatory caspases inhibitor. Ac-FLTD-CMK is effective against *caspases-1* (IC₅₀ of 46.7 nM), *caspases-4* (IC₅₀ of 1.49 μM), *caspases-5* (IC₅₀ of 329 nM), and *caspases-11* , but not the apoptotic caspases such as caspase-3 .

HY-W748591

Cannflavin A	Apoptosis Amyloid-β	Cancer
Cannflavin A can be isolated from Cannabis sativa L. Cannflavin A has anti-cancer, neuroprotective and anti-inflammatory activity. Cannflavin A inhibits Aβ1-42 aggregation. Cannflavin A also inhibits kynurenine-3-monooxygenase (KMO). Cannflavin A activates apoptosis via caspase-3 cleavage .

HY-D1432

FITC-C6-DEVD-FMK	Fluorescent Dye	Cancer
FITC-C6-DEVD-FMK, a fluorescently labeled caspase-3 inhibitor, can be used for detection of active caspase-3 in mammalian cells undergoing apoptosis. FITC-C6-DEVD-FMK provides a convenient means for sensitive detection of activated caspase-3 in living cells. Z-DEVD-FMK is a specific caspase-3 inhibitor .

HY-18980

Rottlerin 5 Publications Verification MallotoxIN; NSC 56346; NSC 94525	PKC Autophagy Apoptosis HIV RABV	Infection Cancer
Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC₅₀ values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation . Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection .

HY-13610

N1,N11-Diethylnorspermine	Caspase	Cancer
N1,N11-Diethylnorspermine (DENSPM) is a potent anticancer agent. N1,N11-Diethylnorspermine is a spermine analog that activates polyamine catabolism. N1,N11-Diethylnorspermine induces the release of cytochrome c from mitochondria, resulting in activation of *caspase 3*. N1,N11-Diethylnorspermine kills glioblastoma multiforme (GBM) cells through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production .

HY-N3584

Paris saponin VII 1 Publications Verification Chonglou SaponIN VII	Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis	Cancer
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of *Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt*. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

Cat. No.	Product Name	Type

HY-P2614

Mca-DEVDAP-K(Dnp)-OH

Chromogenic Substrates

Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for caspase-3 .
HY-P3475

Mca-VDQMDGW-K(Dnp)-NH2

Fluorescent Dyes/Probes

Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .

Mca-DEVDAP-K(Dnp)-OH	Chromogenic Substrates
Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for *caspase-3* .

Mca-VDQMDGW-K(Dnp)-NH2	Fluorescent Dyes/Probes
Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .

HY-D1432

FITC-C6-DEVD-FMK	Fluorescent Dyes/Probes
FITC-C6-DEVD-FMK, a fluorescently labeled caspase-3 inhibitor, can be used for detection of active caspase-3 in mammalian cells undergoing apoptosis. FITC-C6-DEVD-FMK provides a convenient means for sensitive detection of activated caspase-3 in living cells. Z-DEVD-FMK is a specific caspase-3 inhibitor .

Cat. No.	Product Name	Target	Research Area

HY-P2614

Mca-DEVDAP-K(Dnp)-OH

Caspase Others

Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for caspase-3 .
HY-W792412

Z-YVAD-CMK

Caspase Cancer

Z-YVAD-CMK is a caspase-1 and caspase-3 inhibitor .
HY-P5936

Ac-AAVALLPAVLLALLAP-DEVD-CHO

DEVD-CHO-CPP 32
Caspase Cancer

Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) is a potent and reversible caspase-3 inhibitor .
HY-P3475

Mca-VDQMDGW-K(Dnp)-NH2

Fluorescent Dye Others

Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .

Mca-DEVDAP-K(Dnp)-OH	Caspase	Others
Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for *caspase-3* .

Z-YVAD-CMK	Caspase	Cancer
Z-YVAD-CMK is a *caspase-1* and *caspase-3* inhibitor .

Ac-AAVALLPAVLLALLAP-DEVD-CHO DEVD-CHO-CPP 32	Caspase	Cancer
Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) is a potent and reversible *caspase-3* inhibitor .

Mca-VDQMDGW-K(Dnp)-NH2	Fluorescent Dye	Others
Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .

HY-P2228

Chlamydocin	HDAC Apoptosis	Cancer
Chlamydocin, a fungal metabolite, is a highly potent HDAC inhibitor, with an IC₅₀ of 1.3 nM. Chlamydocin exhibits potent antiproliferative and anticancer activities. Chlamydocin induces apoptosis by activating caspase-3 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6681

15-Acetoxyscirpenol	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Caspase Bacterial Apoptosis Antibiotic
15-acetoxyscirpenol, one of acetoxyscirpenol moiety mycotoxins (ASMs), strongly induces apoptosis and inhibits Jurkat T cell growth in a dose-dependent manner by activating other *caspases* independent of caspase-3 .

HY-N7930

Crenulatin	Structural Classification Classification of Application Fields Source classification Crassulaceae Other Diseases Plants Disease Research Fields Rhodiola crenulata (HK. f. et.Thoms) H. Ohba Saccharides	Others
Crenulatin is a gallotannin that can be isolated from Rhodiola rosea. Crenulatin can be used as a biomarker to identify potentially adulterated R. rosea products. Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, via regulating Fas/Bcl-2 expression and caspase-3 activity .

HY-W748591

Cannflavin A	Structural Classification Flavonoids Cannabis sativa L Flavones Source classification Plants Moraceae	Apoptosis Amyloid-β
Cannflavin A can be isolated from Cannabis sativa L. Cannflavin A has anti-cancer, neuroprotective and anti-inflammatory activity. Cannflavin A inhibits Aβ1-42 aggregation. Cannflavin A also inhibits kynurenine-3-monooxygenase (KMO). Cannflavin A activates apoptosis via caspase-3 cleavage .

HY-18980

Rottlerin 5 Publications Verification MallotoxIN; NSC 56346; NSC 94525	Structural Classification Chalcones Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Euphorbiaceae Plants Disease Research Fields Mallotus philippensis Cancer	PKC Autophagy Apoptosis HIV RABV
Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC₅₀ values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation . Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection .

HY-N12503

Patuletin	Structural Classification Flavonols Flavonoids Source classification Amaranthaceae Plants Spinacia oleracea L.	Apoptosis Caspase
Patuletin is a flavonol, that can be isolated from the flowers of Tagetes patula. Patuletin shows anti-proliferative activity against cancer cells. Patuletin causes significant nuclear fragmentation and has a great capacity to induce *caspase-3* activation .

HY-N3584

Paris saponin VII 1 Publications Verification Chonglou SaponIN VII	Liliaceae Classification of Application Fields Source classification Trillium tschonoskii Maxim. Plants Disease Research Fields Steroids Cancer	Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of *Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt*. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

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Caspase-3-IN-1

Inhibitors & Agonists

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Natural
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