1. Apoptosis
  2. Caspase
  3. N1,N11-Diethylnorspermine

N1,N11-Diethylnorspermine 

Cat. No.: HY-13610
Handling Instructions

N1,N11-Diethylnorspermine (DENSPM) is a potent anticancer agent. N1,N11-Diethylnorspermine is a spermine analog that activates polyamine catabolism. N1,N11-Diethylnorspermine induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine kills glioblastoma multiforme (GBM) cells through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production.

For research use only. We do not sell to patients.

N1,N11-Diethylnorspermine Chemical Structure

N1,N11-Diethylnorspermine Chemical Structure

CAS No. : 121749-39-1

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Description

N1,N11-Diethylnorspermine (DENSPM) is a potent anticancer agent. N1,N11-Diethylnorspermine is a spermine analog that activates polyamine catabolism. N1,N11-Diethylnorspermine induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine kills glioblastoma multiforme (GBM) cells through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production[1][2][3].

IC50 & Target

Caspase 3

 

In Vivo

N1,N11-Diethylnorspermine (40 mg/kg, three times per day for two cycles of 6 days) clearly prevents tumor growth in mice bearing xenografts of the DU-145 cell line[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

244.42

Formula

C13H32N4

CAS No.
SMILES

CCNCCCNCCCNCCCNCC

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
N1,N11-Diethylnorspermine
Cat. No.:
HY-13610
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