2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Apoptosis Bcl-2 Family Caspase PARP
  4. Anticancer agent 43

Anticancer Agent 43 is a potent anticancer agent. Anticancer Agent 43 induces apoptosis by caspase 3, PARP1, and Bax dependent mechanisms. Anticancer Agent 43 induces DNA damage.

For research use only. We do not sell to patients.

Anticancer agent 43 Chemical Structure

Anticancer agent 43 Chemical Structure

CAS No. : 2470015-35-9

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Based on 1 publication(s) in Google Scholar

Anticancer agent 43 Related Antibodies

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

Anticancer Agent 43 is a potent anticancer agent. Anticancer Agent 43 induces apoptosis by caspase 3, PARP1, and Bax dependent mechanisms. Anticancer Agent 43 induces DNA damage[1].

IC50 & Target[1]

Caspase 3

 

PARP1

 

Bax

 

In Vitro

Anticancer agent 43 (compound 3a) shows selectivity toward human tumor cells (SI50=28.94)[1].
Anticancer agent 43 (45 µM, 24 h) induces apoptosis via caspase 3, PARP1 and Bax dependent pathways in HepG2 cells[1].
Anticancer agent 43 (45 µM, 24 h) shows no effect on the transition of G1/S phases in HepG2 cells[1].
Anticancer agent 43 (0.7, 45, 55 µM) induces DNA damage in HCT116 cells (Tail DNA=16.1%, OTM=3.7), MCF-7 cells, HepG2 cells (Tail DNA=26.2%, OTM=13.2), Balb/c 3T3 cells (Tail DNA = 8.4%, OTM = 3.5)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 43 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HepG2, MCF-7, HCT116, HeLa, A549, WM793, THP-1, HaCaT, Balb/c3T3 cells
Concentration: 0, 1, 10, 100 µM
Incubation Time: 72 h
Result: Showed cytotoxic action with GI50s of 12.1, 0.7, 0.8, 49.3, 9.7 µM for for HepG2, MCF-7, HCT116, HeLa, A549 cells, low toxicity towards WM793, THP-1, HaCaT, Balb/c 3T3 cells with GI50s of 80.4, 62.4,98.3,40.8 µM , respectively.

Apoptosis Analysis[1]

Cell Line: HepG2 cells
Concentration: 45 µM
Incubation Time: 24 h
Result: Induced apoptosis in HepG2 cells via caspase 3, PARP1 and Bax dependent pathways.

Western Blot Analysis[1]

Cell Line: HCT116, MCF-7 cells
Concentration: 0.7 µM
Incubation Time: 24 h
Result: Decreased the expression of Cdk2 protein in HCT116 and MCF-7 cells.

Cell Cycle Analysis[1]

Cell Line: HepG2 cells
Concentration: 45 µM
Incubation Time: 24 h
Result: Showed no effect on the transition of G1/S phases in HepG2 cells.
Molecular Weight

336.36

Formula

C14H9FN2O3S2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

COC(C1=C(C2=C(N1)C=CC(F)=C2)/C=C3SC(NC\3=O)=S)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (371.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9730 mL 14.8650 mL 29.7301 mL
5 mM 0.5946 mL 2.9730 mL 5.9460 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9730 mL 14.8650 mL 29.7301 mL 74.3251 mL
5 mM 0.5946 mL 2.9730 mL 5.9460 mL 14.8650 mL
10 mM 0.2973 mL 1.4865 mL 2.9730 mL 7.4325 mL
15 mM 0.1982 mL 0.9910 mL 1.9820 mL 4.9550 mL
20 mM 0.1487 mL 0.7433 mL 1.4865 mL 3.7163 mL
25 mM 0.1189 mL 0.5946 mL 1.1892 mL 2.9730 mL
30 mM 0.0991 mL 0.4955 mL 0.9910 mL 2.4775 mL
40 mM 0.0743 mL 0.3716 mL 0.7433 mL 1.8581 mL
50 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.4865 mL
60 mM 0.0496 mL 0.2478 mL 0.4955 mL 1.2388 mL
80 mM 0.0372 mL 0.1858 mL 0.3716 mL 0.9291 mL
100 mM 0.0297 mL 0.1487 mL 0.2973 mL 0.7433 mL
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Anticancer agent 43 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 432470015-35-9Anticancer agent43Anticancer agent-43ApoptosisBcl-2 FamilyCaspasePARPpoly ADP ribose polymeraseCytotoxicityapotpsisDNA damageHepG2 cellsHCT116 cellsMCF-7 cellsselectiveInhibitorinhibitorinhibit

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