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Paris saponin VII

(Synonyms: Chonglou Saponin VII)
5 Cited Publications
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Based on 5 publication(s) in Google Scholar

Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia.

For research use only. We do not sell to patients.

  • Purity: 99.84%
  • CAS No.: 68124-04-9
  • Formula: C51H82O21
  • Molecular Weight:1031.18
  • Storage:

    -20°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • Paris saponin VII Chemical Structure
    Paris saponin VII Chemical Structure
  • Experimental Validation Results for Paris saponin VII
  • Experimental Validation Results for Paris saponin VII
  • Experimental Validation Results for Paris saponin VII
  • Experimental Validation Results for Paris saponin VII
  • Experimental Validation Results for Paris saponin VII
CAS No.: 68124-04-9
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Cell Proliferation/Viability AssayCell Migration/Invasion AssayApoptosis AnalysisIFWB
  • Cell Proliferation/Viability Assay
  • Cell Migration/Invasion Assay
  • Apoptosis Analysis
  • IF
  • WB

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All p38 MAPK Isoforms

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All Bcl-2 Family Isoforms

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All Caspase Isoforms

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All PARP Isoforms

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  • Paris saponin VII Chemical Structure
    Paris saponin VII Chemical Structure
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    Paris saponin VII purchased from MedChemExpress. Usage Cited in: Chem Biol Interact. 2025 Aug 25:417:111562. [Abstract]

    Customer Validation
     The effects of different concentrations of Paris saponin VII (PS VII) (2, 4 μM) on the proliferation rate of ovarian cancer SKOV3 PARPi-R and HEY PARPi-R cells were detected by CCK-8

  • 1/16

    Paris saponin VII purchased from MedChemExpress. Usage Cited in: Chem Biol Interact. 2025 Aug 25:417:111562. [Abstract]

    Customer Validation
     The effects of different concentrations of Paris saponin VII (PS VII) (2, 4 μM) on the migration abilities of ovarian cancer SKOV3 PARPi-R and HEY PARPi-R cells were evaluated by wound healing assays.

  • 1/16

    Paris saponin VII purchased from MedChemExpress. Usage Cited in: Chem Biol Interact. 2025 Aug 25:417:111562. [Abstract]

    Customer Validation
     The apoptosis of ovarian cancer SKOV3 PARPi-R and HEY PARPi-R cells was determined using flow cytometry at different concentrations of Paris saponin VII (PS VII) (2, 4 μM).

  • 1/16

    Paris saponin VII purchased from MedChemExpress. Usage Cited in: Chem Biol Interact. 2025 Aug 25:417:111562. [Abstract]

    Customer Validation
     The impact of PS VII and RORα on tube formation in human umbilical vein endothelial cells (HUVECs) is examined using conditioned medium derived from PARPi-resistant ovarian cancer cells with RORα inhibition treated with Paris saponin VII (PS VII).

  • 1/16

    Paris saponin VII purchased from MedChemExpress. Usage Cited in: Chem Biol Interact. 2025 Aug 25:417:111562. [Abstract]

    Customer Validation
     The effect of Paris saponin VII (PS VII) and RORα on glycolysis, angiogenesis, and metastasis-related proteins in PARPi-resistant ovarian cancer cells is analyzed using Western blot.

  • Paris saponin VII