1. PI3K/Akt/mTOR
    MAPK/ERK Pathway
    Membrane Transporter/Ion Channel
    Apoptosis
    Epigenetics
    Cell Cycle/DNA Damage
    Autophagy
  2. Akt
    p38 MAPK
    P-glycoprotein
    Bcl-2 Family
    Caspase
    PARP
    Autophagy
    Apoptosis
  3. Paris saponin VII

Paris saponin VII (Synonyms: Chonglou Saponin VII)

Cat. No.: HY-N3584 Purity: 99.13%
Handling Instructions

Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia.

For research use only. We do not sell to patients.

Paris saponin VII Chemical Structure

Paris saponin VII Chemical Structure

CAS No. : 68124-04-9

Size Price Stock Quantity
5 mg USD 135 In-stock
Estimated Time of Arrival: December 31
10 mg USD 230 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia[1].

IC50 & Target[1]

Akt

 

p38

 

Bcl-2

 

Caspase-9

 

Caspase-3

 

PARP-1

 

In Vitro

Paris saponin VII (Chonglou Saponin VII) inhibits the growth of adriamycin-resistant human leukemia cells (K562/ADR) in a dose-dependent manner. Paris saponin VII significantly suppresses cell proliferation by cell cycle arrest in the G0/G1 phase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Paris saponin VII (Chonglou Saponin VII) (intravenous administration) significantly enhances anticancer efficacy of adriamycin to MCF-7/ADR xenograft model in nude mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1031.18

Formula

C₅₁H₈₂O₂₁

CAS No.

68124-04-9

SMILES

O[[email protected]@]12[[email protected]@]3([[email protected]@]([[email protected]@]4([H])[[email protected]]([[email protected]@]5(C(C[[email protected]@H](O[[email protected]@]6([H])[[email protected]@H]([[email protected]]([[email protected]](O[[email protected]@]7([H])[[email protected]@H]([[email protected]@H]([[email protected]@H](O[[email protected]@]8([H])[[email protected]@H]([[email protected]@H]([[email protected]@H](O)[[email protected]](C)O8)O)O)[[email protected]](C)O7)O)O)[[email protected]@H](CO)O6)O)O[[email protected]@]9([H])[[email protected]@H]([[email protected]@H]([[email protected]@H](O)[[email protected]](C)O9)O)O)CC5)=CC4)C)([H])CC3)([H])C[[email protected]]1([H])O[[email protected]]%10(CC[[email protected]@H](C)CO%10)[[email protected]]2C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (96.98 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9698 mL 4.8488 mL 9.6976 mL
5 mM 0.1940 mL 0.9698 mL 1.9395 mL
10 mM 0.0970 mL 0.4849 mL 0.9698 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (2.42 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.42 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.42 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Paris saponin VIIChonglou Saponin VIIAktp38 MAPKP-glycoproteinBcl-2 FamilyCaspasePARPAutophagyApoptosisPKBProtein kinase BP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243poly ADP ribose polymerase Inhibitorinhibitorinhibit

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Product Name:
Paris saponin VII
Cat. No.:
HY-N3584
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