1. PI3K/Akt/mTOR
    MAPK/ERK Pathway
    Membrane Transporter/Ion Channel
    Apoptosis
    Epigenetics
    Cell Cycle/DNA Damage
    Autophagy
  2. Akt
    p38 MAPK
    P-glycoprotein
    Bcl-2 Family
    Caspase
    PARP
    Autophagy
  3. Paris saponin VII

Paris saponin VII (Synonyms: Chonglou Saponin VII)

Cat. No.: HY-N3584
Handling Instructions

Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia.

For research use only. We do not sell to patients.

Paris saponin VII Chemical Structure

Paris saponin VII Chemical Structure

CAS No. : 68124-04-9

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Description

Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia[1].

IC50 & Target[1]

Akt

 

p38

 

Bcl-2

 

Caspase-9

 

Caspase-3

 

PARP-1

 

In Vitro

Paris saponin VII (Chonglou Saponin VII) inhibits the growth of adriamycin-resistant human leukemia cells (K562/ADR) in a dose-dependent manner. Paris saponin VII significantly suppresses cell proliferation by cell cycle arrest in the G0/G1 phase[1].

In Vivo

Paris saponin VII (Chonglou Saponin VII) (intravenous administration) significantly enhances anticancer efficacy of adriamycin to MCF-7/ADR xenograft model in nude mice[2].

Molecular Weight

1031.18

Formula

C₅₁H₈₂O₂₁

CAS No.

68124-04-9

SMILES

O[[email protected]@]12[[email protected]@]3([[email protected]@]([[email protected]@]4([H])[[email protected]]([[email protected]@]5(C(C[[email protected]@H](O[[email protected]@]6([H])[[email protected]@H]([[email protected]]([[email protected]](O[[email protected]@]7([H])[[email protected]@H]([[email protected]@H]([[email protected]@H](O[[email protected]@]8([H])[[email protected]@H]([[email protected]@H]([[email protected]@H](O)[[email protected]](C)O8)O)O)[[email protected]](C)O7)O)O)[[email protected]@H](CO)O6)O)O[[email protected]@]9([H])[[email protected]@H]([[email protected]@H]([[email protected]@H](O)[[email protected]](C)O9)O)O)CC5)=CC4)C)([H])CC3)([H])C[[email protected]]1([H])O[[email protected]]%10(CC[[email protected]@H](C)CO%10)[[email protected]]2C)C

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Paris saponin VII
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