1. Apoptosis
  2. Apoptosis
  3. Tubeimoside I

Tubeimoside I (Synonyms: Tubeimoside-1; Lobatoside-H)

Cat. No.: HY-N0890 Purity: 98.03%
Handling Instructions

Tubeimoside I(Lobatoside-H) is an extract from Chinese herbal medicine Bolbostemma paniculatum (MAXIM.

For research use only. We do not sell to patients.

Tubeimoside I Chemical Structure

Tubeimoside I Chemical Structure

CAS No. : 102040-03-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 107 In-stock
Estimated Time of Arrival: December 31
10 mg USD 74 In-stock
Estimated Time of Arrival: December 31
50 mg USD 221 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Tubeimoside I(Lobatoside-H) is an extract from Chinese herbal medicine Bolbostemma paniculatum (MAXIM.) FRANQUET (Cucurbitaceae) has been shown as a potent anti-tumor agent for a variety of human cancers. IC50 value: Target: Anticancer natural compound in vitro: TBMS I inhibited the proliferation of both HepG2 and L-02 cells in a dose- and time-dependent manner, but HepG2 cells appeared more sensitive to the agent. When exposed to TBMS I for 24, 48 and 72 h, IC50 for HepG2 cells versus L-02 cells were 15.5 vs. 23.1, 11.7 vs. 16.2, 9.2 vs. 13.1 (μM, p<0.01), respectively. TBMS I induced cell shrinkage, nuclear condensation and fragmentation, cell cycle arrest at the G2/M phase, mitochondrial membrane disruption, release of cytochrome c from the mitochondria, activation of caspase 3 and 9, and shifting Bax/Bcl-2 ratio from being anti-apoptotic to pro-apoptotic, all indicative of initiation and progression of apoptosis involving mitochondrial dysfunction [1]. TBMS1-induced molecular events were related to mitochondria-induced intrinsic apoptosis and P21-cyclin B1/cdc2 complex-related G2/M cell cycle arrest [2]. TBMS1 combined with CDDP promoted cell apoptosis, decreased proliferation activity and increased cytosolic Ca2+ levels. Bcl-2 protein expression was down-regulated but Bax was up-regulated. Moreover, GST-π mRNA and protein expression were decreased. TBMS1 reduced the resistance of the cells to CDDP-induced cytotoxicity [4]. Treatment with TBMS1 resulted in dose- and time-dependent inhibition of proliferation, led to arrest in phase G2/M of the cell cycle and increased the levels of intracellular Ca2 . Furthermore, TBMS1 up-regulated the levels of the glucose-regulated protein 78/immunoglobuin heavy chain binding protein (GRP78/Bip), C/EBP homologous protein (CHOP), Bax, and cleaved caspase-3 and down-regulated the levels of Bcl-2 [5]. in vivo: TBMS1 significantly inhibited the production of the pro-inflammatory cytokines, TNF-α, IL-6 and IL-1β in vitro and in vivo. Pretreatment with TBMS1 markedly attenuated the development of pulmonary edema, histological severities and inflammatory cells infiltration in mice with ALI [3].

Molecular Weight

1319.44

Formula

C₆₃H₉₈O₂₉

CAS No.

102040-03-9

SMILES

O=C(O[[email protected]](OCC(O)[[email protected]]1O)[[email protected]@H]1OC(OC(C)C(OC(CC(O)(CC(O[[email protected]@H]2[[email protected]]3O)=O)C)=O)C4OC(OCC(O)C5O)C5O)C4O)C6(CCC(C)(C)C7)C7C8=CCC9C(C)(CCC%10C9(CC(O)C(OC(OC(CO)C(O)C%11O)C%11O[[email protected]](OC2)[[email protected]@H]3O)C%10(C)CO)C)C8(C)CC6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (75.79 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7579 mL 3.7895 mL 7.5790 mL
5 mM 0.1516 mL 0.7579 mL 1.5158 mL
10 mM 0.0758 mL 0.3789 mL 0.7579 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (1.89 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (1.89 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (1.89 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Tubeimoside ITubeimoside-1Lobatoside-HTubeimoside1Tubeimoside 1ApoptosisInhibitorinhibitorinhibit

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