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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

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HepG2 liver carcinoma cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Aryl Hydrocarbon Receptor (1) Bcl-2 Family (1) Caspase (1) Cytochrome P450 (1) Drug Derivative (4) E1/E2/E3 Enzyme (1) Endogenous Metabolite (1) Glycoprotein VI (1) HIV (1) JNK (1) Ligands for E3 Ligase (1) MDM-2/p53 (1) Molecular Glues (1) Notch (1) Parasite (1) PARP (1) PROTACs (1) Pyruvate Kinase (1) Reactive Oxygen Species (ROS) (1) Reference Standards (2) STAT (1) Toll-like Receptor (TLR) (5) TrxR (1)
By Research Areas:	Cancer (16) Infection (3) Inflammation/Immunology (1)

By Targets:

Apoptosis (2)

Aryl Hydrocarbon Receptor (1)

Bcl-2 Family (1)

Caspase (1)

Cytochrome P450 (1)

Drug Derivative (4)

E1/E2/E3 Enzyme (1)

Endogenous Metabolite (1)

Glycoprotein VI (1)

HIV (1)

JNK (1)

Ligands for E3 Ligase (1)

MDM-2/p53 (1)

Molecular Glues (1)

Notch (1)

Parasite (1)

PARP (1)

PROTACs (1)

Pyruvate Kinase (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (2)

STAT (1)

Toll-like Receptor (TLR) (5)

TrxR (1)

By Research Areas:

Cancer (16)

Infection (3)

Inflammation/Immunology (1)

Inhibitors & Agonists

Peptides

Natural
Products

Targets Recommended: LXR Nuclear Factor of activated T Cells (NFAT) TREM receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103697

Gardiquimod	Toll-like Receptor (TLR)	Cancer
Gardiquimod is an imidazoline TLR7/8 agonist. Gardiquimod inhibits HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod specifically activates TLR7 at concentrations below 10 μM.

HY-103697A

Gardiquimod diTFA	Toll-like Receptor (TLR)	Cancer
Gardiquimod diTFA is an imidazoline TLR7/8 agonist. Gardiquimod diTFA inhibits HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod diTFA specifically activates TLR7 at concentrations below 10 μM.

HY-163502

PROTAC STAT3 degrader-3	PROTACs STAT	Cancer
PROTAC STAT3 degrader-3 is a STAT3 PROTAC degrader. PROTAC STAT3 degrader-3 recruits the E3 ubiquitin ligase CRBN and induces the degradation of STAT3 protein. PROTAC STAT3 degrader-3 inhibits the proliferation of malignant tumor cells. PROTAC STAT3 degrader-3 can be used for the research of non-small cell lung cancer and liver cancer .

HY-146350

TrxR-IN-4	TrxR Reactive Oxygen Species (ROS) Apoptosis	Cancer
TrxR-IN-4 is a thioredoxin reductase (TrxR) inhibitor with a rat IC₅₀ of 0.37 μM. TrxR-IN-4 inhibits TrxR activity, elevates reactive oxygen species (ROS) and induces apoptosis. TrxR-IN-4 mediates endoplasmic reticulum stress and induces mitochondrial dysfunction. TrxR-IN-4 can be used for the research of hepatocellular carcinoma .

HY-N15577

Antiproliferative agent-69	Drug Derivative	Cancer
Antiproliferative agent-69 (Compound 1) is a prenylated kaempferol derivative found in the fresh bud’s fur of Platanus acerifolia. Antiproliferative agent-69 shows significant antiproliferative effects against human breast cancer cells (MCF-7) and human hepatocellular carcinoma cells (Hep-G2) with IC₅₀ values of 38.2 μM and 39.5 μM, respectively. Antiproliferative agent-69 is promising for research of breast cancer and liver cancer .

HY-129247

Versicolorin A	MDM-2/p53 Aryl Hydrocarbon Receptor Cytochrome P450	Cancer
Versicolorin A is a biosynthetic precursor of Aflatoxin B1 (HY-N6615). Versicolorin A induces phosphorylation of p53. Versicolorin A activates the aryl hydrocarbon receptor AhR and significantly induces the expression of CYP1A1. Versicolorin A exerts genotoxic and cytotoxic effects. Versicolorin A enhances the genotoxicity of aflatoxin B1 in cells by promoting CYP450-mediated bioactivation of aflatoxin B1. Versicolorin A can be used in research related to colorectal cancer and hepatocellular carcinoma .

HY-N10207

Penicitide A	Endogenous Metabolite	Infection Cancer
Penicitide A is a marine secondary metabolite. Penicitide A shows moderate cytotoxicity against pathogen A. brassicae and the human hepatocellular liver carcinoma (HepG2) cell line .

HY-N15535

Cuneataside E	Others	Cancer
Cuneataside E is a phenylpropanoid glycoside compound found in Lespedeza cuneata. Cuneataside E exhibits hepatoprotective activity against the toxicity induced by N-acetyl-p-aminophenol (APAP) in the human hepatocellular carcinoma cell line HepG2. Cuneataside E is promising for research of liver diseases .

HY-153547

HSP90-IN-21	Parasite	Infection Inflammation/Immunology
HSP90-IN-21 (5e) is an antiplasmodial agent, with IC₅₀ values of 0.04, 0.17 and 2.91 μM against erythrocytic stage of P. falciparum (Pf3D7 and PfDd2 strains), cytotoxicity of human liver hepatocellular carcinoma cell line (HepG2), respectively .

HY-168337

SET-171	JNK Pyruvate Kinase
SET-171 is a JNK (c-Jun N-terminal kinase) inhibitor that exhibits significant anticancer activity and lipid metabolism regulation by inhibiting liver pyruvate kinase (PKL) expression. In anticancer studies, SET-171 shows IC₅₀ values of 8.82 μM and 2.97 μM against HepG2 and Huh7 cell lines, respectively, indicating high cytotoxicity. Additionally, in non-alcoholic fatty liver disease (NAFLD)-related studies, SET-171 significantly reduces triacylglycerol (TAG) levels and inhibits the expression of steatosis-related proteins. SET-171 holds promise for research on hepatocellular carcinoma (HCC) and NAFLD .

HY-103697AR

Gardiquimod diTFA (Standard)	Toll-like Receptor (TLR) Reference Standards	Cancer
Gardiquimod (diTFA) (Standard) is the analytical standard of Gardiquimod (diTFA). This product is intended for research and analytical applications. Gardiquimod diTFA is an imidazoline TLR7/8 agonist. Gardiquimod diTFA inhibits HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod diTFA specifically activates TLR7 at concentrations below 10 μM.

HY-103697R

Gardiquimod (Standard)	Toll-like Receptor (TLR) Reference Standards	Cancer
Gardiquimod (Standard) is the analytical standard of Gardiquimod. This product is intended for research and analytical applications. Gardiquimod is an imidazoline TLR7/8 agonist. Gardiquimod inhibits HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod specifically activates TLR7 at concentrations below 10 μM.

HY-103697B

Gardiquimod hydrochloride	HIV Toll-like Receptor (TLR)	Infection Cancer
Gardiquimod (hydrochloride) is an imidazoline TLR7/8 agonist. Gardiquimod (hydrochloride) inhibits HIV-1 infection of macrophages and activates peripheral blood mononuclear cells (PBMCs). Gardiquimod (hydrochloride) specifically activates TLR7 at concentrations below 10 μM .

HY-151570

Anticancer agent 87	Drug Derivative	Cancer
Anticancer agent 87 is a spirooxindole-furan derivative with anticancer activity. Anticancer agent 87 can be used for the research of breast adenocarcinoma and human liver cancer .

HY-W727102

(Z)-8-β-D-Glucopyranosyloxycinnamic acid	Others	Others
(Z)-8-β-D-Glucopyranosyloxycinnamic acid is a phenolic glycoside present in the roots of Codonopsis javanica. (Z)-8-β-D-Glucopyranosyloxycinnamic acid exhibits no toxicity against lung cancer, liver cancer and breast cancer cell lines .

HY-N20646

Kanokoside A Xiecaoiridoidside C	Others	Cancer
Kanokoside A (Xiecaoiridoidside C) is an iridoid glycoside that can be found in the roots of Centranthus longiflorus ssp. longiflorus, as well as the roots and rhizomes of Valeriana amurensis. Kanokoside A exhibits weak cytotoxicity against gastric cancer, liver cancer and breast cancer cells .

HY-151572

Anticancer agent 88	Drug Derivative	Cancer
Anticancer agent 88 is a spirooxindole-furan derivative with anticancer activity. Anticancer agent 88 can be used for the research of breast adenocarcinoma and human liver cancer .

HY-N16857

Didendronbiline A	Drug Derivative	Others
Didendronbiline A is a natural phenolic compound.

HY-182008

NEURL1B-IN-1	Molecular Glues E1/E2/E3 Enzyme Apoptosis Notch PARP Caspase Bcl-2 Family Ligands for E3 Ligase	Cancer
NEURL1B-IN-1 is a molecular glue-like NEURL1B degrader with a Kd value of 46.2 nM. NEURL1B-IN-1 binds to Arg422 within the NHR2 domain of NEURL1B, triggers its autoubiquitination and proteasomal degradation, disrupts its interaction with DLL1, and attenuates the Notch signaling pathway. NEURL1B-IN-1 induces cell cycle arrest and apoptosis, and inhibits migration of hepatocellular carcinoma cells. NEURL1B-IN-1 is applicable to research related to hepatocellular carcinoma .

HY-P11618

10P3Me	Glycoprotein VI	Cancer
10P3Me is a Glypican-3 (GPC3)-targeting probe with a K_a of 93.8 nM for the human target. 10P3Me exhibits high binding affinity to GPC3, targets GPC3-positive cells, and serves as an agent for PET imaging. 10P3Me selectively accumulates in GPC3-positive tumor tissues, including subcutaneous xenograft models and orthotopic HepG2-LUC liver cancer models, to achieve precise localization of lesions .

Cat. No.	Product Name	Target	Research Area

HY-P11618

10P3Me	Glycoprotein VI	Cancer
10P3Me is a Glypican-3 (GPC3)-targeting probe with a K_a of 93.8 nM for the human target. 10P3Me exhibits high binding affinity to GPC3, targets GPC3-positive cells, and serves as an agent for PET imaging. 10P3Me selectively accumulates in GPC3-positive tumor tissues, including subcutaneous xenograft models and orthotopic HepG2-LUC liver cancer models, to achieve precise localization of lesions .

Antiproliferative agent-69	Flavonols Platanus acerifolia Aiton) Willd. Flavonoids Platanaceae Plants Source Classification	Drug Derivative
Antiproliferative agent-69 (Compound 1) is a prenylated kaempferol derivative found in the fresh bud’s fur of Platanus acerifolia. Antiproliferative agent-69 shows significant antiproliferative effects against human breast cancer cells (MCF-7) and human hepatocellular carcinoma cells (Hep-G2) with IC₅₀ values of 38.2 μM and 39.5 μM, respectively. Antiproliferative agent-69 is promising for research of breast cancer and liver cancer .

Versicolorin A	Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Other Diseases Disease Research Fields Source Classification	MDM-2/p53 Aryl Hydrocarbon Receptor Cytochrome P450
Versicolorin A is a biosynthetic precursor of Aflatoxin B1 (HY-N6615). Versicolorin A induces phosphorylation of p53. Versicolorin A activates the aryl hydrocarbon receptor AhR and significantly induces the expression of CYP1A1. Versicolorin A exerts genotoxic and cytotoxic effects. Versicolorin A enhances the genotoxicity of aflatoxin B1 in cells by promoting CYP450-mediated bioactivation of aflatoxin B1. Versicolorin A can be used in research related to colorectal cancer and hepatocellular carcinoma .

Penicitide A	Infection Natural Products Microorganisms Classification of Application Fields Marine natural products Disease Research Fields Marine microorganism Source Classification	Endogenous Metabolite
Penicitide A is a marine secondary metabolite. Penicitide A shows moderate cytotoxicity against pathogen A. brassicae and the human hepatocellular liver carcinoma (HepG2) cell line .

Cuneataside E	Piperaceae Piper crocatum Ruiz & Pav. Plants Saccharides Monosaccharides Source Classification	Others
Cuneataside E is a phenylpropanoid glycoside compound found in Lespedeza cuneata. Cuneataside E exhibits hepatoprotective activity against the toxicity induced by N-acetyl-p-aminophenol (APAP) in the human hepatocellular carcinoma cell line HepG2. Cuneataside E is promising for research of liver diseases .

(Z)-8-β-D-Glucopyranosyloxycinnamic acid	Structural Classification Ketones, Aldehydes, Acids Campanulaceae Plants Codonopsis javanica (Blume) Hook. f. Source Classification	Others
(Z)-8-β-D-Glucopyranosyloxycinnamic acid is a phenolic glycoside present in the roots of Codonopsis javanica. (Z)-8-β-D-Glucopyranosyloxycinnamic acid exhibits no toxicity against lung cancer, liver cancer and breast cancer cell lines .

Kanokoside A Xiecaoiridoidside C	Structural Classification Natural Products Caprifoliaceae Centranthus longiflorus ssp. longiflorus Plants Source Classification	Others
Kanokoside A (Xiecaoiridoidside C) is an iridoid glycoside that can be found in the roots of Centranthus longiflorus ssp. longiflorus, as well as the roots and rhizomes of Valeriana amurensis. Kanokoside A exhibits weak cytotoxicity against gastric cancer, liver cancer and breast cancer cells .

Didendronbiline A	Structural Classification Orchidaceae Phenols Plants Dendrobium nobile Lindl. Source Classification	Drug Derivative
Didendronbiline A is a natural phenolic compound.

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