HSP90-IN-21
HSP90-IN-21 (5e) is an antiplasmodial agent, with IC50 values of 0.04, 0.17 and 2.91 μM against erythrocytic stage of P. falciparum (Pf3D7 and PfDd2 strains), cytotoxicity of human liver hepatocellular carcinoma cell line (HepG2), respectively.
For research use only. We do not sell to patients.
- CAS No.: 2521791-38-6
- Formula: C24H22ClN3O2
- Molecular Weight:419.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Parasite Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Erythrocyte | IC50 |
0.04 μM
Compound: 70e
|
Antiplasmodial activity against chloroquine-sensitive erythrocyte stage Plasmodium falciparum 3D7 assessed as inhibition of parasite growth incubated for 3 days by ELISA
Antiplasmodial activity against chloroquine-sensitive erythrocyte stage Plasmodium falciparum 3D7 assessed as inhibition of parasite growth incubated for 3 days by ELISA
|
[PMID: 36931118] |
| Erythrocyte | IC50 |
0.17 μM
Compound: 70e
|
Antiplasmodial activity against chloroquine-resistant erythrocyte stage Plasmodium falciparum Dd2 assessed as inhibition of parasite growth incubated for 3 days by ELISA
Antiplasmodial activity against chloroquine-resistant erythrocyte stage Plasmodium falciparum Dd2 assessed as inhibition of parasite growth incubated for 3 days by ELISA
|
[PMID: 36931118] |
Chemical Information
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CAS No. 2521791-38-6
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Molecular Weight 419.90
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Formula C24H22ClN3O2
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SMILES
ClC(C=C1)=CC=C1/C=C/C(NCCN2C3=CC(OC)=CC=C3C4=CC=NC(C)=C42)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)