1. Immunology/Inflammation
    Anti-infection
  2. Toll-like Receptor (TLR)
    HIV
  3. Gardiquimod

Gardiquimod 

Cat. No.: HY-103697
Handling Instructions

Gardiquimod, an imidazoquinoline analog, is a TLR7/8 agonist. Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod specifically activates TLR7 when used at concentrations below 10 μM.

For research use only. We do not sell to patients.

Gardiquimod Chemical Structure

Gardiquimod Chemical Structure

CAS No. : 1020412-43-4

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Description

Gardiquimod, an imidazoquinoline analog, is a TLR7/8 agonist. Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod specifically activates TLR7 when used at concentrations below 10 μM[1][2].

IC50 & Target[1]

TLR7

 

TLR8

 

HIV-1

 

In Vitro

Gardiquimod (6-60 μM ) significantly inhibits cDNA synthesis by HIV-1 reverse transcriptase[1].

In Vivo

Dendritic cells (DCs) in combination with Gardiquimod (1 mg/kg per mouse; i.p.; daily for 7 days) improves the anti-tumor effects of NK cells[2].

Animal Model: Male athymic nude mice (Balb-nu/nu, 5 weeks old) (bearing human HepG2 liver carcinoma xenografts)[2]
Dosage: 1 mg/kg per mouse
Administration: i.p.; daily for 7 days
Result: Significantly suppressed the growth of human HepG2 liver carcinoma xenografts.
Molecular Weight

313.40

Formula

C₁₇H₂₃N₅O

CAS No.

1020412-43-4

SMILES

OC(C)(C)CN1C(CNCC)=NC2=C1C3=CC=CC=C3N=C2N

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

GardiquimodToll-like Receptor (TLR)HIVHuman immunodeficiency virusHIV-1macrophagesperipheralbloodmononuclearcellsPBMCsHepG2livercarcinomaInhibitorinhibitorinhibit

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Gardiquimod
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