2. Immunology/Inflammation
  3. Glycoprotein VI
  4. 10P3Me

10P3Me is a Glypican-3 (GPC3)-targeting probe with a Ka of 93.8 nM for the human target. 10P3Me exhibits high binding affinity to GPC3, targets GPC3-positive cells, and serves as an agent for PET imaging. 10P3Me selectively accumulates in GPC3-positive tumor tissues, including subcutaneous xenograft models and orthotopic HepG2-LUC liver cancer models, to achieve precise localization of lesions.

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10P3Me

10P3Me Chemical Structure

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10P3Me Related Antibodies

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Description

10P3Me is a Glypican-3 (GPC3)-targeting probe with a Ka of 93.8 nM for the human target. 10P3Me exhibits high binding affinity to GPC3, targets GPC3-positive cells, and serves as an agent for PET imaging. 10P3Me selectively accumulates in GPC3-positive tumor tissues, including subcutaneous xenograft models and orthotopic HepG2-LUC liver cancer models, to achieve precise localization of lesions[1].

In Vitro

10P3Me (1 μCi per well; 0.5-4 h) exhibits significantly higher uptake in GPC3-high HepG2, Hep3B2.1-7, and Huh-7 cells compared to GPC3-low H1975 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

10P3Me Related Antibodies
In Vivo

10P3Me (200-300 μCi; i.v.) exhibits specific and high tumor uptake, as well as a long retention time in subcutaneous HCC xenograft models with high GPC3 expression[1].
10P3Me (150-200 μCi; i.v.) exhibits high peak tumor uptake and an optimal tumor-to-liver ratio in HepG2 xenograft models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic nude mice (female, 4−6 weeks old, 18−22 g, subcutaneous xenograft hepatocellular carcinoma model)[1]
Dosage: 200−300 μCi
Administration: i.v.; static scans at 60 and 120 min post-injection
Result: Reached peak tumor uptake of 5.62% ID/mL at 1 h and 3.53% ID/mL at 2 h post-injection in HepG2 xenograft models.
Achieved SUVmean of 5.09% ID/mL at 1 h, which was 3.97 times higher than in GPC3-low H1975 models.
Markedly reduced tumor accumulation in blocking groups and H1975 models.
Animal Model: Athymic nude mice (female, 4−6 weeks old, 18−22 g, orthotopic xenograft hepatocellular carcinoma model)[1]
Dosage: 200−300 μCi
Administration: i.v.; PET imaging at 1 h post-injection
Result: Clearly localized intrahepatic tumor lesions in the left hepatic lobe via PET/CT imaging at 1 h post-injection, which was confirmed by surgical dissection.
Animal Model: Athymic nude mice (female, 4−6 weeks old, 18−22 g, subcutaneous xenograft hepatocellular carcinoma model)[1]
Dosage: 150−200 μCi
Administration: i.v.; assessed at 10, 30, 60, 120, and 240 min post-injection
Result: Reached peak tumor uptake of 6.92% ID/g at 30 min post-injection.
Achieved a tumor-to-liver ratio of 8.28 at 60 min post-injection.
Molecular Weight

2215.55

Formula

C101H151N23O29S2
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Purity & Documentation
References
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10P3Me Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

10P3MeGlycoprotein VIGPVIHuh?7 cellsHepG2 cellsHepG2-LUC liver tumor modelsGlypican-3recombinant human GPC3 proteinH1975 cellshepatocellular carcinomaGPC3Hep3B2.1?7 cellssubcutaneous HCC xenograft modelsInhibitorinhibitorinhibit

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