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SLC7A11 activator

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Amino acid Transporter (2) Apoptosis (2) c-Myc (1) ERK (1) Ferroptosis (8) Fluorescent Dye (1) FOXO (1) Glutathione Peroxidase (8) GSK-3 (1) IFNAR (1) Influenza Virus (1) Interleukin Related (1) IRE1 (3) Isotope-Labeled Compounds (1) JNK (1) Keap1-Nrf2 (3) MDM-2/p53 (1) MyD88 (1) NF-κB (2) Orphan GPCR (1) p38 MAPK (1) PGE synthase (1) PKA (1) Prostaglandin Receptor (1) Reactive Oxygen Species (ROS) (3) Reference Standards (1) Sirtuin (1) STAT (1) Toll-like Receptor (TLR) (1) TrxR (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Endocrinology (1) Infection (2) Inflammation/Immunology (1) Metabolic Disease (6) Neurological Disease (2)

By Targets:

Akt (1)

Amino acid Transporter (2)

Apoptosis (2)

c-Myc (1)

ERK (1)

Ferroptosis (8)

Fluorescent Dye (1)

FOXO (1)

Glutathione Peroxidase (8)

GSK-3 (1)

IFNAR (1)

Influenza Virus (1)

Interleukin Related (1)

IRE1 (3)

Isotope-Labeled Compounds (1)

JNK (1)

Keap1-Nrf2 (3)

MDM-2/p53 (1)

MyD88 (1)

NF-κB (2)

Orphan GPCR (1)

p38 MAPK (1)

PGE synthase (1)

PKA (1)

Prostaglandin Receptor (1)

Reactive Oxygen Species (ROS) (3)

Reference Standards (1)

Sirtuin (1)

STAT (1)

Toll-like Receptor (TLR) (1)

TrxR (1)

By Research Areas:

Cancer (4)

Cardiovascular Disease (1)

Endocrinology (1)

Infection (2)

Inflammation/Immunology (1)

Metabolic Disease (6)

Neurological Disease (2)

Inhibitors & Agonists

Fluorescent Dyes

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: URAT1 Oct3/4 Dopamine Transporter SLC39 (Zinc Transporter) Serotonin Transporter Apical Sodium-Dependent Bile Acid Transporter

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W018161

Hexadecanedioic acid 1 Publications Verification Thapsic acid	IRE1 Ferroptosis Keap1-Nrf2 Glutathione Peroxidase	Metabolic Disease
Hexadecanedioic acid (Thapsic acid) is an orally active metabolite produced by B. uniformis. Hexadecanedioic acid inhibits IRE1α-XBP1s-mediated flipogenesis and ferroptosis. Hexadecanedioic acid downregulates XBP1 and Hrd1 expression, activates the *Nrf2/SLC7A11/GPX4* pathway. Hexadecanedioic acid can be used for the research of metabolic-associated fatty liver disease .

HY-N10549

Gigantol 1 Publications Verification	Ferroptosis c-Myc Glutathione Peroxidase JNK Reactive Oxygen Species (ROS) GSK-3	Infection Metabolic Disease Cancer
Gigantol is an orally active bibenzyl compound. Gigantol targets MYC to promote its ubiquitin-proteasomal degradation and inhibit the growth of lung cancer cells. Gigantol exerts anti-lung cancer activity by inducing ferroptosis (Ferroptosis) via the *SLC7A11-GPX4* axis. Gigantol restores the sensitivity of mcr-harboring multidrug-resistant bacteria to colistin. Gigantol ameliorates carbon tetrachloride-induced liver injury by inhibiting the activation of the JNK/cPLA2/12-LOX inflammatory pathway. Gigantol promotes cholesterol metabolism and progesterone biosynthesis in Leydig cells. Gigantol can be used in studies related to diseases such as lung cancer, multidrug-resistant Gram-negative bacterial infections, and acute liver injury .

HY-W402682

SXC2023	Amino acid Transporter	Neurological Disease Cancer
SXC2023 is a glutamatergic reagent and cystine-glutamate antiporter (System xc ⁻) activator. SXC2023 can affect *SLC7A11*. SXC2023 is applicable to the research of colorectal cancer and trichotillomania .

HY-179041

SZ0232	PGE synthase Prostaglandin Receptor MDM-2/p53 Amino acid Transporter Glutathione Peroxidase Ferroptosis	Metabolic Disease Endocrinology
SZ0232 is a selective mPGES-2 inhibitor. SZ0232 binds to the active site of mPGES-2 via hydrogen bonds and π-π stacking, reduces the production of prostaglandin E₂ (PGE₂) and blocks the PGE₂-EP3 pathway. SZ0232 regulates Ferroptosis by activating the heme-dependent *p53/SLC7A11/GPX4* axis, inhibits lipid peroxidation, and protects renal tubules. SZ0232 enhances glucose-stimulated insulin secretion, inhibits β-cell senescence, and improves glucose homeostasis. SZ0232 reduces renal lipid accumulation, alleviates fibrosis, and ameliorates renal dysfunction in diabetic mice. SZ0232 inhibits renal cyst growth in polycystic kidney disease models. SZ0232 exhibits an insulinotropic effect that strengthens with the increase of animal age. SZ0232 can be used in studies related to type 2 diabetes, acute kidney injury, diabetic kidney disease, and autosomal dominant polycystic kidney disease .

HY-W018161R

Hexadecanedioic acid (Standard) Thapsic acid (Standard)	Reference Standards IRE1 Ferroptosis Keap1-Nrf2 Glutathione Peroxidase	Metabolic Disease
Hexadecanedioic acid (Thapsic acid) (Standard) is the analytical standard of Hexadecanedioic acid (HY-W018161). This product is intended for research and analytical applications. Hexadecanedioic acid is an orally active metabolite produced by B. uniformis. Hexadecanedioic acid inhibits IRE1α-XBP1s-mediated flipogenesis and ferroptosis. Hexadecanedioic acid downregulates XBP1 and Hrd1 expression, activates the *Nrf2/SLC7A11/GPX4* pathway. Hexadecanedioic acid can be used for the research of metabolic-associated fatty liver disease .

HY-P5762A

Phoenixin-14 TFA PNX-14 TFA	Orphan GPCR Glutathione Peroxidase Ferroptosis ERK Toll-like Receptor (TLR) Sirtuin FOXO Akt PKA MyD88 Reactive Oxygen Species (ROS) Apoptosis NF-κB	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Phoenixin-14 (PNX-14) TFA is an endogenous neuropeptide with multiple biological activities, and serves as the endogenous ligand of GPR173. Phoenixin-14 TFA reduces ROS production by inhibiting the HMGB1/TLR4/MyD88/NF-κB signaling axis, thereby exerting antioxidant and mitochondrial protective effects. Phoenixin-14 TFA inhibits FOXO3 phosphorylation by upregulating SIRT3 expression, suppresses apoptosis, and improves myocardial systolic/diastolic function. Phoenixin-14 TFA resists ferroptosis by activating the *ATF4/SLC7A11/GPX4* axis; it activates ERK1/2 phosphorylation via GPR173. Phoenixin-14 TFA can be used in researches on neuroprotection, diabetes, cardiomyopathy, reproductive protection and so on .

HY-W018161S

Hexadecanedioic acid-d28	Isotope-Labeled Compounds IRE1 Ferroptosis Keap1-Nrf2 Glutathione Peroxidase	Metabolic Disease
Hexadecanedioic acid-d₂₈ is the deuterium labeled Hexadecanedioic acid (HY-W018161). Hexadecanedioic acid (Thapsic acid) is an orally active metabolite produced by B. uniformis. Hexadecanedioic acid inhibits IRE1α-XBP1s-mediated flipogenesis and ferroptosis. Hexadecanedioic acid downregulates XBP1 and Hrd1 expression, activates the *Nrf2/SLC7A11/GPX4* pathway. Hexadecanedioic acid can be used for the research of metabolic-associated fatty liver disease .

HY-183554

Fa-Au	TrxR Glutathione Peroxidase Ferroptosis Reactive Oxygen Species (ROS) IFNAR STAT	Cancer
Fa-Au is a TrxR inhibitor. Fa-Au downregulates GPX4, induces oxidative stress, mitochondria-associated ferroptosis (ferroptosis) and immunogenic cell death. Fa-Au induces ROS production in hepatoma cells. Fa-Au remodels the tumor immune microenvironment via M1 macrophage polarization, dendritic cell maturation, CD8+ T cell activation and reduction of regulatory T cells. Fa-Au induces an anti-tumor immune feedback loop through the IFNγ/STAT1/SLC7A11 axis. Fa-Au inhibits tumor growth. Fa-Au is applicable to hepatocellular carcinoma-related research .

HY-D3311

M1219	Fluorescent Dye	Cancer
M1219 is a GSH/ATP dual near-infrared activated fluorescent probe that enables independent real-time monitoring of dynamic changes in intracellular GSH and ATP without spectral crosstalk (GSH: Ex=640 nm, Em=740~800 nm; ATP: Ex=594 nm/610 nm, Em=650~700 nm). M1219 not only visualizes the metabolic regulatory mechanism of TNBC under single/dual-target inhibition of SLC7A11/GLUT1 and accurately evaluates its in vivo efficacy, but also achieves precise localization of the TNBC tumor invasion boundary. M1219 can be used for the research of triple-negative breast cancer .

HY-N17850

5-Hydroxy-6,7-dimethoxyflavone	Influenza Virus Ferroptosis Apoptosis Glutathione Peroxidase NF-κB p38 MAPK Interleukin Related	Infection
5-Hydroxy-6,7-dimethoxyflavone is an orally active inhibitor of ferroptosis (Ferroptosis). 5-Hydroxy-6,7-dimethoxyflavone inhibits H1N1 virus-induced ferroptosis by upregulating the expression of *SLC7A11* and GPX4. 5-Hydroxy-6,7-dimethoxyflavone alleviates inflammatory responses and inhibits apoptosis by suppressing the activation of the NF-κB and p38 MAPK signaling pathways. 5-Hydroxy-6,7-dimethoxyflavone can be used in studies related to H1N1 influenza virus infection .

Cat. No.	Product Name	Type

HY-D3311

M1219	Fluorescent Dyes
M1219 is a GSH/ATP dual near-infrared activated fluorescent probe that enables independent real-time monitoring of dynamic changes in intracellular GSH and ATP without spectral crosstalk (GSH: Ex=640 nm, Em=740~800 nm; ATP: Ex=594 nm/610 nm, Em=650~700 nm). M1219 not only visualizes the metabolic regulatory mechanism of TNBC under single/dual-target inhibition of SLC7A11/GLUT1 and accurately evaluates its in vivo efficacy, but also achieves precise localization of the TNBC tumor invasion boundary. M1219 can be used for the research of triple-negative breast cancer .

M1219

Fluorescent Dyes

M1219 is a GSH/ATP dual near-infrared activated fluorescent probe that enables independent real-time monitoring of dynamic changes in intracellular GSH and ATP without spectral crosstalk (GSH: Ex=640 nm, Em=740~800 nm; ATP: Ex=594 nm/610 nm, Em=650~700 nm). M1219 not only visualizes the metabolic regulatory mechanism of TNBC under single/dual-target inhibition of SLC7A11/GLUT1 and accurately evaluates its in vivo efficacy, but also achieves precise localization of the TNBC tumor invasion boundary. M1219 can be used for the research of triple-negative breast cancer .

Cat. No.	Product Name	Target	Research Area

HY-P5762A

Phoenixin-14 TFA PNX-14 TFA	Orphan GPCR Glutathione Peroxidase Ferroptosis ERK Toll-like Receptor (TLR) Sirtuin FOXO Akt PKA MyD88 Reactive Oxygen Species (ROS) Apoptosis NF-κB	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Phoenixin-14 (PNX-14) TFA is an endogenous neuropeptide with multiple biological activities, and serves as the endogenous ligand of GPR173. Phoenixin-14 TFA reduces ROS production by inhibiting the HMGB1/TLR4/MyD88/NF-κB signaling axis, thereby exerting antioxidant and mitochondrial protective effects. Phoenixin-14 TFA inhibits FOXO3 phosphorylation by upregulating SIRT3 expression, suppresses apoptosis, and improves myocardial systolic/diastolic function. Phoenixin-14 TFA resists ferroptosis by activating the *ATF4/SLC7A11/GPX4* axis; it activates ERK1/2 phosphorylation via GPR173. Phoenixin-14 TFA can be used in researches on neuroprotection, diabetes, cardiomyopathy, reproductive protection and so on .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W018161

Hexadecanedioic acid 1 Publications Verification Thapsic acid	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	IRE1 Ferroptosis Keap1-Nrf2 Glutathione Peroxidase
Hexadecanedioic acid (Thapsic acid) is an orally active metabolite produced by B. uniformis. Hexadecanedioic acid inhibits IRE1α-XBP1s-mediated flipogenesis and ferroptosis. Hexadecanedioic acid downregulates XBP1 and Hrd1 expression, activates the *Nrf2/SLC7A11/GPX4* pathway. Hexadecanedioic acid can be used for the research of metabolic-associated fatty liver disease .

HY-N10549

Gigantol 1 Publications Verification	Structural Classification Classification of Application Fields Orchidaceae Other Diseases Phenols Polyphenols Glucosinolates Plants Disease Research Fields Dendrobium nobile Lindl.	Ferroptosis c-Myc Glutathione Peroxidase JNK Reactive Oxygen Species (ROS) GSK-3
Gigantol is an orally active bibenzyl compound. Gigantol targets MYC to promote its ubiquitin-proteasomal degradation and inhibit the growth of lung cancer cells. Gigantol exerts anti-lung cancer activity by inducing ferroptosis (Ferroptosis) via the *SLC7A11-GPX4* axis. Gigantol restores the sensitivity of mcr-harboring multidrug-resistant bacteria to colistin. Gigantol ameliorates carbon tetrachloride-induced liver injury by inhibiting the activation of the JNK/cPLA2/12-LOX inflammatory pathway. Gigantol promotes cholesterol metabolism and progesterone biosynthesis in Leydig cells. Gigantol can be used in studies related to diseases such as lung cancer, multidrug-resistant Gram-negative bacterial infections, and acute liver injury .

HY-W018161R

Hexadecanedioic acid (Standard) Thapsic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards IRE1 Ferroptosis Keap1-Nrf2 Glutathione Peroxidase
Hexadecanedioic acid (Thapsic acid) (Standard) is the analytical standard of Hexadecanedioic acid (HY-W018161). This product is intended for research and analytical applications. Hexadecanedioic acid is an orally active metabolite produced by B. uniformis. Hexadecanedioic acid inhibits IRE1α-XBP1s-mediated flipogenesis and ferroptosis. Hexadecanedioic acid downregulates XBP1 and Hrd1 expression, activates the *Nrf2/SLC7A11/GPX4* pathway. Hexadecanedioic acid can be used for the research of metabolic-associated fatty liver disease .

HY-N17850

5-Hydroxy-6,7-dimethoxyflavone	Structural Classification Flavonoids Flavones Bignoniaceae Plants Oroxylum indicum (Linn.) Bentham ex Kurz Source Classification	Influenza Virus Ferroptosis Apoptosis Glutathione Peroxidase NF-κB p38 MAPK Interleukin Related
5-Hydroxy-6,7-dimethoxyflavone is an orally active inhibitor of ferroptosis (Ferroptosis). 5-Hydroxy-6,7-dimethoxyflavone inhibits H1N1 virus-induced ferroptosis by upregulating the expression of *SLC7A11* and GPX4. 5-Hydroxy-6,7-dimethoxyflavone alleviates inflammatory responses and inhibits apoptosis by suppressing the activation of the NF-κB and p38 MAPK signaling pathways. 5-Hydroxy-6,7-dimethoxyflavone can be used in studies related to H1N1 influenza virus infection .

Cat. No.	Product Name	Chemical Structure

HY-W018161S

Hexadecanedioic acid-d28
Hexadecanedioic acid-d₂₈ is the deuterium labeled Hexadecanedioic acid (HY-W018161). Hexadecanedioic acid (Thapsic acid) is an orally active metabolite produced by B. uniformis. Hexadecanedioic acid inhibits IRE1α-XBP1s-mediated flipogenesis and ferroptosis. Hexadecanedioic acid downregulates XBP1 and Hrd1 expression, activates the *Nrf2/SLC7A11/GPX4* pathway. Hexadecanedioic acid can be used for the research of metabolic-associated fatty liver disease .

Hexadecanedioic acid-d28

Hexadecanedioic acid-d₂₈ is the deuterium labeled Hexadecanedioic acid (HY-W018161). Hexadecanedioic acid (Thapsic acid) is an orally active metabolite produced by B. uniformis. Hexadecanedioic acid inhibits IRE1α-XBP1s-mediated flipogenesis and ferroptosis. Hexadecanedioic acid downregulates XBP1 and Hrd1 expression, activates the Nrf2/SLC7A11/GPX4 pathway. Hexadecanedioic acid can be used for the research of metabolic-associated fatty liver disease .

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SLC7A11 activator

Inhibitors & Agonists

Fluorescent Dyes

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products