Cat. No.: HY-W018161

Hexadecanedioic acid

(Synonyms: Thapsic acid)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Hexadecanedioic acid (Thapsic acid) is an orally active metabolite produced by B. uniformis. Hexadecanedioic acid inhibits IRE1α-XBP1s-mediated flipogenesis and ferroptosis. Hexadecanedioic acid downregulates XBP1 and Hrd1 expression, activates the Nrf2/SLC7A11/GPX4 pathway. Hexadecanedioic acid can be used for the research of metabolic-associated fatty liver disease.

For research use only. We do not sell to patients.

Purity: 98.0%
CAS No.: 505-54-4
Formula: C₁₆H₃₀O₄
Molecular Weight:286.41

Storage:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

Hexadecanedioic acid Chemical Structure

CAS No.: 505-54-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

GPX4

All Glutathione Peroxidase Isoforms :

GPX1
GPX4

In Vitro

Hexadecanedioic acid (40-80 μg/mL; 24 h) reduces hepatic steatosis and inhibits ferroptosis in free fatty acid-induced HepG2 cells by downregulating XBP1 and Hrd1, and upregulating the Nrf2/SLC7A11/GPX4 pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Hexadecanedioic acid (8-16 mg/0.2 mL; I.g.,; every other day; 12 weeks) ameliorates high-fat diet-induced Metabolic Associated Fatty Liver Disease (MAFLD) in male C57BL/6J mice in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (male, 8 weeks old, SPF grade, high-fat diet-induced)^[1]
Dosage:

8 mg/0.2 mL; 16 mg/0.2 mL
Administration:

I.g.,; every other day; 12 weeks
Result:

Reduced body weight, epididymal fat index, liver weight, and liver index compared to HFD-fed control mice.
Reduced hepatocellular steatosis grade and lipid droplet area ratio (16 mg/0.2 mL dose showed greater effect than 8 mg/0.2 mL dose).
Downregulated hepatic mRNA and protein expression of XBP1 and Hrd1, and upregulated mRNA and protein expression of Nrf2, SLC7A11, and GPX4 (16 mg/0.2 mL dose showed more pronounced effects).
Decreased serum levels of LPS, MDA, ROS, Fe²⁺, IL-1β, and TNF-α, and increased serum GSH levels (16 mg/0.2 mL dose had a stronger impact).
Improved hepatic mitochondrial morphology, reducing ferroptosis-related structural damage, and alleviated intestinal mucosal shedding caused by the high-fat diet.
Downregulated ileal mRNA and protein expression of CD36 and MTP, and upregulated epididymal white adipose tissue mRNA and protein expression of PPARγ and FABP4 (16 mg/0.2 mL dose showed more significant modulation).
Downregulated hepatic mRNA and protein expression of DGAT2 and MTP, reduced the p-IRE1α/IRE1α ratio and XBP1s/XBP1u ratio in liver tissue, and reduced serum VLDL levels (16 mg/0.2 mL dose caused a larger decrease).

Chemical Information

CAS No. 505-54-4
Appearance Solid
Molecular Weight 286.41
Formula C₁₆H₃₀O₄
Color White to off-white
SMILES

O=C(O)CCCCCCCCCCCCCCC(O)=O
Synonyms

Thapsic acid
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Publications (1)

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Journal Impact Factor

Nat Commun

Gut symbiont-derived sphingosine modulates vector competence in Aedes mosquitoes. [Abstract]

2024 Sep 19;15(1):8221. PMID: 39300135

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (349.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.4915 mL

17.4575 mL

34.9150 mL

5 mM

0.6983 mL

3.4915 mL

6.9830 mL

10 mM

0.3491 mL

1.7457 mL

3.4915 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang DY, et al. Bacteroides uniformis-generated hexadecanedioic acid ameliorates metabolic-associated fatty liver disease. Gut Microbes. 2025;17(1):2508433. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.4915 mL	17.4575 mL	34.9150 mL	87.2875 mL
	5 mM	0.6983 mL	3.4915 mL	6.9830 mL	17.4575 mL
	10 mM	0.3491 mL	1.7457 mL	3.4915 mL	8.7287 mL
	15 mM	0.2328 mL	1.1638 mL	2.3277 mL	5.8192 mL
	20 mM	0.1746 mL	0.8729 mL	1.7457 mL	4.3644 mL
	25 mM	0.1397 mL	0.6983 mL	1.3966 mL	3.4915 mL
	30 mM	0.1164 mL	0.5819 mL	1.1638 mL	2.9096 mL
	40 mM	0.0873 mL	0.4364 mL	0.8729 mL	2.1822 mL
	50 mM	0.0698 mL	0.3491 mL	0.6983 mL	1.7457 mL
	60 mM	0.0582 mL	0.2910 mL	0.5819 mL	1.4548 mL
	80 mM	0.0436 mL	0.2182 mL	0.4364 mL	1.0911 mL
	100 mM	0.0349 mL	0.1746 mL	0.3491 mL	0.8729 mL

Hexadecanedioic acid

1 Cited Publications

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Hexadecanedioic acid

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Publications Citing Use of MedChemExpress (MCE) Hexadecanedioic acid

All Glutathione Peroxidase Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Hexadecanedioic acid Related Classifications

HY-W018161 Related Classifications