5-Hydroxy-6,7-dimethoxyflavone
5-Hydroxy-6,7-dimethoxyflavone is an orally active inhibitor of ferroptosis (Ferroptosis). 5-Hydroxy-6,7-dimethoxyflavone inhibits H1N1 virus-induced ferroptosis by upregulating the expression of SLC7A11 and GPX4. 5-Hydroxy-6,7-dimethoxyflavone alleviates inflammatory responses and inhibits apoptosis by suppressing the activation of the NF-κB and p38 MAPK signaling pathways. 5-Hydroxy-6,7-dimethoxyflavone can be used in studies related to H1N1 influenza virus infection.
For research use only. We do not sell to patients.
- CAS No.: 2035-05-4
- Formula: C17H14O5
- Molecular Weight:298.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
5-Hydroxy-6,7-dimethoxyflavone (25-75 μg/mL; 24 h) inhibits H1N1-induced activation of the p38 MAPK and NF-κB signaling pathways, and reduces the expression of IL-8 in A549 cells[1].
5-Hydroxy-6,7-dimethoxyflavone (25-75 μg/mL; 24 h) inhibits H1N1-induced apoptosis and ferroptosis in A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (female, 6 weeks old, 20 g, infected with H1N1 virus via nasal instillation)[1]
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Dosage:30 mg/kg; 60 mg/kg
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Administration:p.o.; once daily; 7 days
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Result:Increased mouse body weight.
Reduced lung index.
Alleviated histopathological lung damage including alveolitis, lung vasculitis, peribronchiolar inflammation, and bronchiolar epithelial sloughing.
Chemical Information
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CAS No. 2035-05-4
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Molecular Weight 298.29
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Formula C17H14O5
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SMILES
O=C1C=C(C2=CC=CC=C2)OC3=CC(O)=C(C(OC)=C13)OC
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5-Hydroxy-6,7-dimethoxyflavone Related Classifications
HY-N17850 Related Classifications
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