2. Anti-infection Apoptosis Metabolic Enzyme/Protease NF-κB MAPK/ERK Pathway Immunology/Inflammation
  3. Influenza Virus Ferroptosis Apoptosis Glutathione Peroxidase NF-κB p38 MAPK Interleukin Related
  4. 5-Hydroxy-6,7-dimethoxyflavone

5-Hydroxy-6,7-dimethoxyflavone is an orally active inhibitor of ferroptosis (Ferroptosis). 5-Hydroxy-6,7-dimethoxyflavone inhibits H1N1 virus-induced ferroptosis by upregulating the expression of SLC7A11 and GPX4. 5-Hydroxy-6,7-dimethoxyflavone alleviates inflammatory responses and inhibits apoptosis by suppressing the activation of the NF-κB and p38 MAPK signaling pathways. 5-Hydroxy-6,7-dimethoxyflavone can be used in studies related to H1N1 influenza virus infection.

For research use only. We do not sell to patients.

5-Hydroxy-6,7-dimethoxyflavone

5-Hydroxy-6,7-dimethoxyflavone Chemical Structure

CAS No. : 2035-05-4

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

5-Hydroxy-6,7-dimethoxyflavone Related Antibodies

Top Publications Citing Use of Products

View All Glutathione Peroxidase Isoform Specific Products:

View All Isoforms
GPX1 GPX4

View All NF-κB Isoform Specific Products:

View All Isoforms
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

5-Hydroxy-6,7-dimethoxyflavone is an orally active inhibitor of ferroptosis (Ferroptosis). 5-Hydroxy-6,7-dimethoxyflavone inhibits H1N1 virus-induced ferroptosis by upregulating the expression of SLC7A11 and GPX4. 5-Hydroxy-6,7-dimethoxyflavone alleviates inflammatory responses and inhibits apoptosis by suppressing the activation of the NF-κB and p38 MAPK signaling pathways. 5-Hydroxy-6,7-dimethoxyflavone can be used in studies related to H1N1 influenza virus infection[1].

In Vitro

5-Hydroxy-6,7-dimethoxyflavone (25-75 μg/mL; 24 h) inhibits H1N1-induced activation of the p38 MAPK and NF-κB signaling pathways, and reduces the expression of IL-8 in A549 cells[1].
5-Hydroxy-6,7-dimethoxyflavone (25-75 μg/mL; 24 h) inhibits H1N1-induced apoptosis and ferroptosis in A549 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5-Hydroxy-6,7-dimethoxyflavone Related Antibodies
In Vivo

5-Hydroxy-6,7-dimethoxyflavone (30-60 mg/kg; p.o.; once daily; 7 days) improves body weight, reduces lung index, and mitigates lung tissue damage in H1N1 influenza virus-infected mice, demonstrating protective activity against influenza-induced lung injury[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (female, 6 weeks old, 20 g, infected with H1N1 virus via nasal instillation)[1]
Dosage: 30 mg/kg; 60 mg/kg
Administration: p.o.; once daily; 7 days
Result: Increased mouse body weight.
Reduced lung index.
Alleviated histopathological lung damage including alveolitis, lung vasculitis, peribronchiolar inflammation, and bronchiolar epithelial sloughing.
Molecular Weight

298.29

Formula

C17H14O5
CAS No.
SMILES

O=C1C=C(C2=CC=CC=C2)OC3=CC(O)=C(C(OC)=C13)OC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

5-Hydroxy-6,7-dimethoxyflavone Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Hydroxy-6,7-dimethoxyflavone2035-05-4Influenza VirusFerroptosisApoptosisGlutathione PeroxidaseNF-κBp38 MAPKInterleukin RelatedNuclear factor-κBNuclear factor-kappaBILNF-κB p65ferroptosisGPX4cleaved PARPH1N1 influenza viruscleaved caspase3SLC7A11TRAILIL-8Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
5-Hydroxy-6,7-dimethoxyflavone
Cat. No.:
HY-N17850
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.