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Results for "

Steroid 5α- reductase

" in MedChemExpress (MCE) Product Catalog:

37

Inhibitors & Agonists

1

Biochemical Assay Reagents

12

Natural
Products

1

Recombinant Proteins

3

Isotope-Labeled Compounds

1

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-135794
    11-Ketodihydrotestosterone
    1 Publications Verification

    11-KDHT; -Dihydro-11-keto testosterone

    Androgen Receptor Endocrinology
    11-Ketodihydrotestosterone (11-KDHT; -Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 11-Ketodihydrotestosterone is an active androgen and is also a potent androgen receptor (AR) agonist with a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. 11-Ketodihydrotestosterone drives gene regulation, protein expression and cell growth in androgen-dependent prostate cancer cells .
    11-Ketodihydrotestosterone
  • HY-107819

    Dihydrocholesterol; -Cholestanol; NSC 18188

    Endogenous Metabolite Others
    -Cholestan-3β-ol is a derivitized steroid compound.
    5α-Cholestan-3β-ol
  • HY-N2489

    BrassinoSteroid BB 16; DI 31

    Biochemical Assay Reagents Others
    -Hydroxy-laxogenin (Brassinosteroid BB 16; DI 31) is a derivative of laxogenin, a spirostane-type steroid. -Hydroxy-laxogenin serves as a plant-derived anabolic agent and is used as a dietary supplement .
    5α-Hydroxy-laxogenin
  • HY-E70558

    5 alpha Reductase Metabolic Disease
    -reductase, Rat (Sprague-Dawley) Liver is an enzyme involved in steroid metabolism and participates in the androgen metabolic pathway. -reductase, Rat (Sprague-Dawley) Liver catalyzes the conversion of testosterone to -dihydrotestosterone (DHT). DHT plays important roles in the development of male sex organs, hair growth, prostate function, and other aspects .
    5α-reductase, Rat(Sprague-Dawley) Liver
  • HY-W677042

    -Androst-16-en-3α-ol

    GABA Receptor Neurological Disease
    α-Androstenol (-Androst-16-en-3α-ol) is a steroid pheromone that has been found in boar testes and male axillary sweat. α-Androstenol is also a positive allosteric modulator of GABAA receptors, which enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50 of 0.4 μM). α-Androstenol produces anxiolytic-like, antidepressant-like, and anticonvulsant effects in mice. α-Androstenol can be used for the research of seizures .
    α-Androstenol
  • HY-135794S

    11-KDHT-d3; -Dihydro-11-keto testosterone-d3

    Isotope-Labeled Compounds Androgen Receptor Endocrinology
    11-Ketodihydrotestosterone-d3 is the deuterium labeled 11-Ketodihydrotestosterone. 11-Ketodihydrotestosterone (11-KDHT; -Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 11-Ketodihydrotestosterone is an active androgen and is also a potent androgen receptor (AR) agonist with a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. 11-Ketodihydrotestosterone drives gene regulation, protein expression and cell growth in androgen-dependent prostate cancer cells .
    11-Ketodihydrotestosterone-d3
  • HY-113364

    -THB

    Glucocorticoid Receptor Endogenous Metabolite Drug Metabolite Metabolic Disease Inflammation/Immunology
    -Tetrahydrocorticosterone (-HB), an endogenous steroid, is a glucocorticoid receptor (GR) agonist and a metabolite of Corticosterone (HY-B1618). -Tetrahydrocorticosterone is an effective topical anti-inflammatory agent in vivo. -Tetrahydrocorticosterone reduces metabolites that bind to GR-Corticosterone and its -reduced metabolites in rat hepatocytes, with a Kd of 268 nM. -Tetrahydrocorticosterone can be used for research on inflammatory skin diseases .
    5α-Tetrahydrocorticosterone
  • HY-103245

    Androgen Receptor Cancer
    Cl-4AS-1, a potent steroidal androgen receptor (AR) agonist (IC50 = 12 nM), is also an inhibitor of -reductase types I and II (IC50 = 6 and 10 nM, respectively) .
    Cl-4AS-1
  • HY-W010934

    Biochemical Assay Reagents Others
    3β,5α,6β-Trihydroxycholestane is a steroid that occurs naturally in the body and is also found in certain foods. It belongs to a class of compounds known as cholestanes, which are closely related to the better known cholesterol. This particular compound is formed from cholesterol through a series of enzymatic reactions in the liver and other organs. It has been studied for its potential health benefits, including its ability to reduce inflammation and oxidative stress in the body. Some research suggests that it may also play a role in regulating blood sugar levels and improving insulin sensitivity. Despite these potential benefits, 3β,5α,6β-Trihydroxycholestane is not widely used as a supplement or medicine due to its relatively low content, focus on natural resources and limited research. However, researchers continue to investigate its potential uses and effects on human health.
    3β,5α,6β-Trihydroxycholestane
  • HY-152094

    5 alpha Reductase Endocrinology
    SRD5A1-IN-1 (Compound 4) is a competitive and covalent steroid -reductase type 1 (SRD5A1) inhibitor with an IC50 of 1.44 µM. SRD5A1-IN-1 modulates SRD5A1 function, leading to a lower level of dihydrotestosterone (DHT) production and SRD5A1 protein suppression .
    SRD5A1-IN-1
  • HY-107819S

    Dihydrocholesterol-d5; -Cholestanol-d5; NSC 18188-d5

    Isotope-Labeled Compounds Endogenous Metabolite Others
    5α-Cholestan-3β-ol-d5 is the deuterium labeled -Cholestan-3β-ol. -Cholestan-3β-ol is a derivitized steroid compound .
    5α-Cholestan-3β-ol-d5
  • HY-106129

    LY 320236

    5 alpha Reductase Endocrinology Cancer
    Izonsteride (Compound LY320236) is an inhibitor of 5α-reductase (IC50 = 11.6 nM for type I; 7.37 nM for type II). LY320236 inhibits the activity of steroid -reductase, preventing the conversion of testosterone (T) to dihydrotestosterone (DHT). LY320236 can significantly inhibit the growth of LNCaP tumors in thymic mice without exhibiting obvious host toxicity .
    Izonsteride
  • HY-W741872

    -DHF

    Drug Metabolite Metabolic Disease
    -Dihydrocortisol (-DHF), a metabolite of Hydrocortisone (Cortisol) (HY-N0583), is a steroid hormone. -Dihydrocortisol can enhance the mineralocorticoid activity of aldosterone .
    5α-Dihydrocortisol
  • HY-123323

    5 alpha Reductase Endocrinology
    MK-0434 is an orally active steroid 5α-reductase inhibitor. MK-0434 specifically inhibits steroid 5α-reductase, thereby reducing the level of dihydrotestosterone (DHT) in the body. MK-0434 can be used in the study of benign prostatic hyperplasia .
    MK-0434
  • HY-19144

    5 alpha Reductase Others
    ONO-3805 is an early lead compound of a non-steroidal -reductase inhibitor, used to inhibit the conversion of testosterone to dihydrotestosterone, with potential effects in inhibiting benign prostatic hyperplasia.
    ONO-3805
  • HY-106363

    L 654066

    5 alpha Reductase Others
    MK-0963 is a steroidal 5α-reductase inhibitor. MK-0963 reduces serum dihydrotestosterone (DHT) concentrations in a dose-dependent manner. MK-0963 can be used for the study of dihydrotestosterone-related diseases such as benign prostate hyperplasia (BPH) .
    MK-0963
  • HY-106614

    Androgen Receptor 5 alpha Reductase Endocrinology
    Osaterone acetate is an orally active steroid anti-androgen agent, mainly used for benign prostatic hyperplasia (BPH) in dogs. Osaterone acetate competitively antagonizes androgen receptor and inhibits 5α-reductase, reducing the concentration of dihydrotestosterone (DHT) while blocking the growth-stimulating effects of testosterone and DHT on prostate cells. Osaterone acetate can rapidly alleviate the symptoms of BPH in dogs without affecting the fertility of breeding dogs .
    Osaterone acetate
  • HY-B1734

    16-DPA

    FXR 5 alpha Reductase Cytochrome P450 Drug Intermediate Cardiovascular Disease Cancer
    16-Dehydropregnenolone acetate (16-DPA), a sterols compound, is an orally active 17α-hydroxylase and 5α-reductase inhibitor. 16-Dehydropregnenolone is also a potent bile acid receptor (BAR)/farnesoid X receptor (FXR) antagonist. 16-Dehydropregnenolone hypolipidemic and anticancer effects. 16-Dehydropregnenolone acetate (16-DPA) is the drug intermediate that can be used for synthesis of Dexamethasone (HY-14648) and related other steroidal pharmacophores .
    16-Dehydropregnenolone acetate
  • HY-135794R

    11-KDHT (Standard); -Dihydro-11-keto testosterone (Standard)

    Reference Standards Androgen Receptor Endocrinology
    11-Ketodihydrotestosterone (Standard) is the analytical standard of 11-Ketodihydrotestosterone. This product is intended for research and analytical applications. 11-Ketodihydrotestosterone (11-KDHT; -Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 11-Ketodihydrotestosterone is an active androgen and is also a potent androgen receptor (AR) agonist with a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. 11-Ketodihydrotestosterone drives gene regulation, protein expression and cell growth in androgen-dependent prostate cancer cells .
    11-Ketodihydrotestosterone (Standard)
  • HY-107819R

    Dihydrocholesterol(Standard); -Cholestanol(Standard); NSC 18188 (Standard)

    Reference Standards Endogenous Metabolite Others
    -Cholestan-3β-ol (Standard) is the analytical standard of -Cholestan-3β-ol. This product is intended for research and analytical applications. -Cholestan-3β-ol is a derivitized steroid compound.
    5α-Cholestan-3β-ol (Standard)
  • HY-N12513R

    Reference Standards Fungal Infection
    -Cholestan-3β-ol (Standard) is the analytical standard of -Cholestan-3β-ol. This product is intended for research and analytical applications. -Cholestan-3β-ol is a derivitized steroid compound.
    Cyclo(L-Phe-trans-4-OH-L-Pro) (Standard)
  • HY-W778920

    Dihydrocholesterol7; -Cholestanol7; NSC 181887

    Isotope-Labeled Compounds Endogenous Metabolite Others
    5α-Cholestan-3β-ol-d7 (Dihydrocholesterol-d7; 5α-Cholestanol-d7; NSC 18188-d7) is the deuterium labeled -Cholestan-3β-ol (HY-107819). -Cholestan-3β-ol is a derivitized steroid compound.
    5α-Cholestan-3β-ol-d7
  • HY-N1202

    Sitostane-3β,,6β-triol

    Others Others
    Sitostanetriol (Sitostane-3β,5α,6β-triol) is a steroid isolated from Casearia membranacea (Flacourtiaceae) .
    Sitostanetriol
  • HY-19284

    FK 687; TF 505

    5 alpha Reductase Endocrinology
    FR-146687 (FK 687) is a selective and orally active 5α-reductase inhibitor with IC50s of 1.7 nM and 4.6 nM for rat and human -reductases, respectively. FR-146687 shows no inhibitory effects on other steroid oxidoreductases .
    FR-146687
  • HY-133949

    5 alpha Reductase Endocrinology
    8,11-Eicosadiynoic acid, an unsaturated fatty acid, is a steroid 5α-reductase inhibitor. 8,11-Eicosadiynoic acid can be used for the research of acne .
    8,11-Eicosadiynoic acid
  • HY-N17596

    11OHDHT; 5a-Dihydro-11β-hydroxytestosterone

    Others Cancer
    11β,17β-Dihydroxy--androstan-3-one (11OHDHT) is a C11-oxy C19 steroid, has a role as an androgen. 11β,17β-Dihydroxy--androstan-3-one can be used for prostate cancer research .
    11β,17β-Dihydroxy-5α-androstan-3-one
  • HY-107850A

    Allopregnanediol

    GnRH Receptor Endocrinology
    -Pregnane-3α,20α-diol (Allopregnanediol) is a derivative of progesterone and is one of the various steroids secreted by the ovaries of rats. -Pregnane-3α,20α-diol can significantly stimulate the release of luteinizing hormone (LH) in castrated rats that have been pre-treated with estrogen, while simultaneously inhibiting the secretion of follicle-stimulating hormone (FSH) .
    5α-Pregnane-3α,20α-diol
  • HY-175719

    5 alpha Reductase Endocrinology
    SRD5A1-IN-2 is a inhibitor of steroid -reductase type-1 (SRD5A1), with an IC50 of 8.5 μM. SRD5A1-IN-2 downregulates SRD5A1 protein expression in HaCaT cells. SRD5A1-IN-2 reduces dihydrotestosterone (DHT) production in HaCaT cells. SRD5A1-IN-2 can be used for the study of androgen-related conditions such as androgenetic alopecia (AGA) .
    SRD5A1-IN-2
  • HY-U00125

    5 alpha Reductase Endocrinology
    CGP-53153 is a steroidal inhibitor of 5 alpha reductase with IC50s of 36 and 262 nM in rat and human prostatic tissue, respectively.
    CGP-53153
  • HY-N16927

    Drug Derivative Others
    5α,8α-Epidioxyergost-6-en-3β-ol is a natural steroid.
    5α,8α-Epidioxyergost-6-en-3β-ol
  • HY-N17043

    Drug Derivative Others
    3β,-Dihydroxystigmastan-6-one is a natural steroid.
    3β,5α-Dihydroxystigmastan-6-one
  • HY-W141312

    Cytochrome P450 Others
    -Androst-2-en-17-one, a steroid, is an aromatase inhibitor.
    5α-Androst-2-en-17-one
  • HY-N17232

    Drug Derivative Others
    5α,6α-Epoxyergosta-8,22-diene-3β,7α-diol is a natural steroid.
    5α,6α-Epoxyergosta-8,22-diene-3β,7α-diol
  • HY-N17230

    Drug Derivative Others
    5α,6α-Epoxyergosta-8(14),22-diene-3β,7α-diol is a natural steroid.
    5α,6α-Epoxyergosta-8(14),22-diene-3β,7α-diol
  • HY-N15362

    Endogenous Metabolite Endocrinology
    -Pregnane-3β,17α,20α-triol is an endogenous steroid compound. -Pregnane-3β,17α,20α-triol is the metabolite of Pregnenolone (HY-B0151) or Progesterone (HY-N0437). -Pregnane-3β,17α,20α-triol is promising for research of the endocrine function of the placenta and the mechanisms related to steroid hormone metabolism during pregnancy .
    5α-Pregnane-3β,17α,20α-triol
  • HY-N9877

    Drug Derivative Others
    22E-7α-Methoxy-5α,6α-epoxyergosta-8(14),22-dien-3β-ol is a natural steroid.
    22E-7α-Methoxy-5α,6α-epoxyergosta-8(14),22-dien-3β-ol
  • HY-103245R

    Reference Standards Androgen Receptor Cancer
    Cl-4AS-1 (Standard) is the analytical standard of Cl-4AS-1 (HY-103245). This product is intended for research and analytical applications. Cl-4AS-1, a potent steroidal androgen receptor (AR) agonist (IC50 = 12 nM), is also an inhibitor of -reductase types I and II (IC50 = 6 and 10 nM, respectively) .
    Cl-4AS-1 (Standard)

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