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  3. Cl-4AS-1

Cl-4AS-1 

Cat. No.: HY-103245
Handling Instructions

Cl-4AS-1, a potent steroidal androgen receptor (AR) agonist (IC50 = 12 nM), is also an inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively).

For research use only. We do not sell to patients.

Cl-4AS-1 Chemical Structure

Cl-4AS-1 Chemical Structure

CAS No. : 188589-66-4

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Description

Cl-4AS-1, a potent steroidal androgen receptor (AR) agonist (IC50 = 12 nM), is also an inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively)[1][2].

IC50 & Target

IC50: 12 nM (androgen receptor); 6 nM (5α-reductase types I); 10 nM (5α-reductase types II)[1][2]

In Vitro

Cl-4AS-1 suppresses MMP-1 promoter activity in 22Rv1 human prostate cancer cells[1].
Cl-4AS-1 (10 μM) effectively promotes the AR N/C interaction, with an average maximal activity of 35.3%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cl-4AS-1 produces no significant reduction in prostate weight in intact animals and in castrates rats caused a significant increase of ventral prostate weight[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ORX rats[1]
Dosage: 10 mg/kg
Administration: I.s.; 7 days
Result: Effect of Cl-4AS-1 on prostate and seminal vesicle growth.
Molecular Weight

441.01

Formula

C₂₆H₃₃ClN₂O₂

CAS No.
Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Cl-4AS-1
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HY-103245
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