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Cat. No.: HY-175719

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SRD5A1-IN-2

SRD5A1-IN-2 is a inhibitor of steroid 5α-reductase type-1 (SRD5A1), with an IC₅₀ of 8.5 μM. SRD5A1-IN-2 downregulates SRD5A1 protein expression in HaCaT cells. SRD5A1-IN-2 reduces dihydrotestosterone (DHT) production in HaCaT cells. SRD5A1-IN-2 can be used for the study of androgen-related conditions such as androgenetic alopecia (AGA).

For research use only. We do not sell to patients.

Formula: C₁₈H₁₂F₆O₄
Molecular Weight:406.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

SRD5A1-IN-2 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

SRD5A1

8.5 μM (IC₅₀)

In Vitro

SRD5A1-IN-2 (Compound 10a) shows cytotoxicity with a half-maximal lethal concentration (LC₅₀) of 21.31 μM in HaCaT cells^[1].
SRD5A1-IN-2 (10 μM, 24 h) inhibits steroid 5α-reductase type-1 (SRD5A1) activity with an IC₅₀ of 8.5 μM and reduces dihydrotestosterone (DHT) production in HaCaT cells^[1].
SRD5A1-IN-2 (2.5-15 μM, 24 h) significantly downregulates SRD5A1 protein expression in HaCaT cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HaCaT cells
Concentration:

2.5, 5, 10, 15 μM
Incubation Time:

24 h
Result:

Downregulated SRD5A1 protein expression in HaCaT cells.

Chemical Information

Molecular Weight 406.28
Formula C₁₈H₁₂F₆O₄
SMILES

COC1=C(C=CC(/C=C/C(OC2=C(C=CC(C(F)(F)F)=C2)C(F)(F)F)=O)=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Isswanich K, et al. Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies. ACS Omega. 2025 Aug 13;10(33):38211-38228. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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