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Cat. No.: HY-175719

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SRD5A1-IN-2

SRD5A1-IN-2 is a inhibitor of steroid 5α-reductase type-1 (SRD5A1), with an IC₅₀ of 8.5 μM. SRD5A1-IN-2 downregulates SRD5A1 protein expression in HaCaT cells. SRD5A1-IN-2 reduces dihydrotestosterone (DHT) production in HaCaT cells. SRD5A1-IN-2 can be used for the study of androgen-related conditions such as androgenetic alopecia (AGA).

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화학식: C₁₈H₁₂F₆O₄
분자량:406.28

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

SRD5A1-IN-2 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

SRD5A1

8.5 μM (IC₅₀)

In Vitro

SRD5A1-IN-2 (Compound 10a) shows cytotoxicity with a half-maximal lethal concentration (LC₅₀) of 21.31 μM in HaCaT cells^[1].
SRD5A1-IN-2 (10 μM, 24 h) inhibits steroid 5α-reductase type-1 (SRD5A1) activity with an IC₅₀ of 8.5 μM and reduces dihydrotestosterone (DHT) production in HaCaT cells^[1].
SRD5A1-IN-2 (2.5-15 μM, 24 h) significantly downregulates SRD5A1 protein expression in HaCaT cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HaCaT cells
Concentration:

2.5, 5, 10, 15 μM
Incubation Time:

24 h
Result:

Downregulated SRD5A1 protein expression in HaCaT cells.

Chemical Information

분자량 406.28
화학식 C₁₈H₁₂F₆O₄
SMILES

COC1=C(C=CC(/C=C/C(OC2=C(C=CC(C(F)(F)F)=C2)C(F)(F)F)=O)=C1)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Isswanich K, et al. Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies. ACS Omega. 2025 Aug 13;10(33):38211-38228. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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