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Telomerase+Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (7) Bacterial (1) Cholinesterase (ChE) (1) DNA/RNA Synthesis (1) EBV (2) G-quadruplex (2) HIV (1) HIV Protease (2) Nucleoside Antimetabolite/Analog (1) Reference Standards (2) Reverse Transcriptase (1) SARS-CoV (1) Telomerase (19)
By Research Areas:	Cancer (21) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (2) Metabolic Disease (1)
Oligonucleotides:	Guanine Nucleotide (1) Guanosine (1) Nucleotide Analogs (1) Nucleoside Analogs (1) Antisense Oligonucleotides (1)

Inhibitors & Agonists

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17353

BIBR 1532 5+ Cited Publications	Telomerase Apoptosis	Cancer
BIBR 1532 is a potent, selective and non-competitive *telomerase* inhibitor with IC₅₀ of 100 nM in a cell-free assay.

HY-108477

TMPyP4 tosylate Maximum Cited Publications 10 Publications Verification TMP 1363	G-quadruplex Telomerase Cholinesterase (ChE) SARS-CoV	Cancer
TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand. TMPyP4 tosylate inhibits the interaction between G-quadruplexes and IGF-1. TMPyP4 tosylate is a *telomerase* inhibitor and inhibits cancer cells proliferation. TMPyP4 tosylate is also a stabilizer of nucleic acid secondary structure and an acetylcholinesterase inhibitor. Besides, TMPyP4 tosylate has antiviral activity against SARS-CoV-2 .

HY-101089

RHPS4 5 Publications Verification	Telomerase Apoptosis	Cancer
RHPS4 is a potent *telomerase* inhibitor (IC₅₀ = 0.33 μM). RHPS4 is a DNA damage inducer .

HY-120145

MST-312 2 Publications Verification Telomerase Inhibitor IX	Telomerase	Cancer
MST-312 is a *telomerase* inhibitor. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 can be used for the research of cancer, such as multiple myeloma (MM) .

HY-N2006

Ganoderic acid B	EBV HIV Protease	Infection Inflammation/Immunology
Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC₅₀: 170 μM) .

HY-12854

Imetelstat GRN163L	Telomerase Apoptosis	Cardiovascular Disease Cancer
Imetelstat (GRN163L) is a 13-mer oligonucleotide and competitive *Telomerase* inhibitor. Imetelstat binds with high affinity to the template region of the RNA component of human telomerase. Imetelstat induces Apoptosis. Imetelstat is capable of selectively eliminating myelofibrosis hematopoietic stem cells. Imetelstat leads to the loss of a cancer cell's ability to maintain telomere length, resulting in the inhibition of cell proliferation .

HY-126483

Telomerase-IN-3	Telomerase	Cancer
Telomerase-IN-3 is a *telomerase* inhibitor, which directly targets hTERT promoter activity. hTERT is the key component for maintenance of telomerase activity .

HY-135775

BMVC 1 Publications Verification	G-quadruplex Telomerase DNA/RNA Synthesis	Cancer
BMVC is a potent G-quadruplex (G4) stabilizer and a selective *telomerase* inhibitor with an IC₅₀ of ~0.2 μM. BMVC inhibits Taq DNA polymerase with an IC₅₀ of ~2.5 μM. BMVC increases the melting temperature of G4 structure of telomere and accelerates telomere length shortening. Anticancer activities .

HY-U00268

Telomerase-IN-1	Telomerase	Cancer
Telomerase-IN-1 is a *Telomerase* inhibitor with an IC₅₀ of 0.19 μM.

HY-204056

Telomerase-IN-8	Telomerase	Cancer
Telomerase-IN-8 is an orally active *telomerase* inhibitor, with an IC₅₀ value of 0.98 μM. Telomerase-IN-8 exhibits potent antiproliferative activity against multiple tumor cell lines, including PC3, Bcap-37, MGC-803 and HepG2. Telomerase-IN-8 demonstrates potent antitumor efficacy in S180 sarcoma or HepG2 hepatoma xenograft mice. Telomerase-IN-8 can be used for the study of telomerase-targeted anticancer .

HY-W602640

2'-Deoxyisoguanosine	Nucleoside Antimetabolite/Analog	Cancer
2'-Deoxyisoguanosine is a purine nucleoside analog. 2'-deoxyisoguanosine has low potency and specificity in inhibiting tumor cell growth, similar to other telomerase inhibitors.

HY-122482

β-Rubromycin	HIV Reverse Transcriptase Telomerase Bacterial	Infection Metabolic Disease Cancer
β-Rubromycin, a quinone antibacterial agent, is a selective HIV-1 reverse transcriptase inhibitor with a K_i of 0.27 μM. β-Rubromycin is a potent *telomerase* inhibitor with an IC₅₀ of 3 μM. β-Rubromycin inhibits the proliferation of both K-562 and HeLa cells with IC₅₀ values of 19.5 µM and 22.7 µM, respectively .

HY-W250161

7-Deaza-2′-deoxyguanosine 5′-triphosphate 7-Deaza-2'-dGTP	Telomerase	Cancer
7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP), a nucleotide analogue, is a *telomerase* inhibitor (IC₅₀: 11 μM) .

HY-171573

3′-Azido-2′,3′-dideoxy-GTP AZddGTP	Telomerase	Others
3′-Azido-2′,3′-dideoxy-GTP (AZddGTP) is a selective *telomerase* inhibitor with a K_i value of 1.5 μM. 3′-Azido-2′,3′-dideoxy-GTP can be incorporated into the 3′-terminus of DNA by telomerase. 3′-Azido-2′,3′-dideoxy-GTP inhibits telomerase activity in HeLa cells in vitro .

HY-179391

Telomerase-IN-9	Telomerase Apoptosis	Cancer
Telomerase-IN-9 is a potent and selective *telomerase* inhibitor. Telomerase-IN-9 significantly reduces telomerase activity by binding to hTERT, leading to decreased telomerase function. Telomerase-IN-9 induces apoptosis and inhibits colony formation. Telomerase-IN-9 reduces tumor burden, restores antioxidantbalance, and preserves lung architecture in a Benzo[a]pyrene (HY-107377)-induced lung cancer mouse model. Telomerase-IN-9 can be used for the research of lung cancer .

HY-163137

Telomerase-IN-6	Telomerase	Cancer
Telomerase-IN-6（6f）is a *telomerase* inhibitor with antitumor activity .

HY-163914

Telomerase-IN-7	Telomerase	Cancer
Telomerase-IN-7 (compound 9) is a *Telomerase* inhibitor with an IC₅₀ of 0.03 μM .

HY-152076

Telomerase-IN-4	Apoptosis	Cancer
Telomerase-IN-4 is a potent *telomerase* inhibitor. Telomerase-IN-4 has antiproliferative activity and induces apoptosis .

HY-152077

Telomerase-IN-5	Apoptosis	Cancer
Telomerase-IN-5 is a potent *telomerase* inhibitor. Telomerase-IN-5 has antiproliferative activity and induces apoptosis .

HY-126482

Telomerase-IN-2	Telomerase	Cancer
Telomerase-IN-2 is a *telomerase* inhibitor, and inhibits telomerase activity by decreasing expression of dyskerin, with an IC₅₀ of 0.89 µM. Anti-cancer activity .

HY-48625

L2H2-6OTD intermediate-2	Telomerase	Cancer
L2H2-6OTD intermediate-2 is an intermediate of telomerase inhibitor, which can be used in the synthesis of ADC .

HY-122092

FJ-5002	Telomerase	Cancer
FJ-5002 is a *telomerase* inhibitor with an IC₅₀ of 2 μM. FJ-5002 can induce telomere shortening, increased chromosomal abnormalities, and senescence/crisis-like features in the human leukemia cell line U937. FJ-5002 exhibits antitumor activity and can be used in the study of cancer .

HY-N2006R

Ganoderic acid B (Standard)	EBV Reference Standards HIV Protease	Infection Inflammation/Immunology
Ganoderic acid B (Standard) is the analytical standard of Ganoderic acid B. This product is intended for research and analytical applications. Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC₅₀: 170 μM) .

HY-101089R

RHPS4 (Standard)	Telomerase Reference Standards Apoptosis	Cancer
RHPS4 (Standard) is the analytical standard of RHPS4 (HY-101089). This product is intended for research and analytical applications. RHPS4 is a potent telomerase inhibitor (IC50 = 0.33 μM). RHPS4 is a DNA damage inducer .

Ganoderic acid B	Infection Triterpenes Classification of Application Fields Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields Source Classification	EBV HIV Protease
Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC₅₀: 170 μM) .

Ganoderic acid B (Standard)	Triterpenes Structural Classification Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Source Classification	EBV Reference Standards HIV Protease
Ganoderic acid B (Standard) is the analytical standard of Ganoderic acid B. This product is intended for research and analytical applications. Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC₅₀: 170 μM) .

Cat. No.	Product Name		Classification

HY-12854

Imetelstat GRN163L		Antisense Oligonucleotides
Imetelstat (GRN163L) is a 13-mer oligonucleotide and competitive *Telomerase* inhibitor. Imetelstat binds with high affinity to the template region of the RNA component of human telomerase. Imetelstat induces Apoptosis. Imetelstat is capable of selectively eliminating myelofibrosis hematopoietic stem cells. Imetelstat leads to the loss of a cancer cell's ability to maintain telomere length, resulting in the inhibition of cell proliferation .

HY-W602640

2'-Deoxyisoguanosine		Nucleoside Analogs Guanosine
2'-Deoxyisoguanosine is a purine nucleoside analog. 2'-deoxyisoguanosine has low potency and specificity in inhibiting tumor cell growth, similar to other telomerase inhibitors.

HY-171573

3′-Azido-2′,3′-dideoxy-GTP AZddGTP		Nucleotide Analogs Guanine Nucleotide
3′-Azido-2′,3′-dideoxy-GTP (AZddGTP) is a selective *telomerase* inhibitor with a K_i value of 1.5 μM. 3′-Azido-2′,3′-dideoxy-GTP can be incorporated into the 3′-terminus of DNA by telomerase. 3′-Azido-2′,3′-dideoxy-GTP inhibits telomerase activity in HeLa cells in vitro .

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Telomerase+Inhibitors

Inhibitors & Agonists

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Oligonucleotides

Natural
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