2. Apoptosis
  3. Apoptosis
  4. Telomerase-IN-4

Telomerase-IN-4 is a potent telomerase inhibitor. Telomerase-IN-4 has antiproliferative activity and induces apoptosis.

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Telomerase-IN-4

Telomerase-IN-4 Chemical Structure

CAS No. : 2892295-10-0

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Telomerase-IN-4 Related Antibodies

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Description

Telomerase-IN-4 is a potent telomerase inhibitor. Telomerase-IN-4 has antiproliferative activity and induces apoptosis[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
17.09 6
Compound: 8e
Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 36525642]
A549 IC50
17.09 6
Compound: 8e
Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 36525642]
MCF7 IC50
9.47 6
Compound: 8e
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 36525642]
MCF7 IC50
9.47 6
Compound: 8e
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 36525642]
In Vitro

Telomerase-IN-4 (compound 8e; 0.1-100 μg/mL; 72 h) has antitumor effects against both cancer cell lines with IC50 values of 9.47 and 17.09 μg/mL for MCF-7 and A549 cells, respectively[1].
Telomerase-IN-4 (9.467 μg/mL; 48 h) arrests cell cycle at the S phase and induces apoptosis in MCF-7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Telomerase-IN-4 Related Antibodies

Cell Viability Assay[1]

Cell Line: MCF-7 and A549 cells
Concentration: 0.1, 1, 10, and 100 μg/mL
Incubation Time: 72 h
Result: Inhibited cell growth in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 9.467 μg/mL
Incubation Time: 48 h
Result: Had an apoptosis percentage of 42.51%.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 9.467 μg/mL
Incubation Time: 48 h
Result: Arrested cell cycle at the S phase of cell growth by more than 1.46 folds compared to that of the control.

Western Blot Analysis[1]

Cell Line: MCF-7 cells
Concentration: 9.467 μg/mL
Incubation Time: 48 h
Result: Decreased in ALT and AST levels by 36.12 and 29.77%, respectively.
In Vivo

Telomerase-IN-4 (5 mg/kg; i.p.; three times per week for two weeks; Swiss albino female mice) has anticancer activity and inhibits tumor growth[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino female mice (25-30 g)[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injectionthree; times per week for two weeks
Result: Reduced both the weight and volume of the tumor by 74.34 and 62.12%, respectively.
Molecular Weight

406.52

Formula

C21H18N4OS2
CAS No.
SMILES

O=C(NC1=C(C#N)C2=C(CCC2)S1)CSC3=NN=C(C=C3)C4=CC=C(C=C4)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Telomerase-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Telomerase-IN-42892295-10-0ApoptosisantiproliferativetumorMCF-7A549S phaseInhibitorinhibitorinhibit

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