country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-152076

Copy Link Print Information

Telomerase-IN-4

Telomerase-IN-4 is a potent telomerase inhibitor. Telomerase-IN-4 has antiproliferative activity and induces apoptosis.

For research use only. We do not sell to patients.

CAS No.: 2892295-10-0
Formula: C₂₁H₁₈N₄OS₂
Molecular Weight:406.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Telomerase-IN-4 Chemical Structure

CAS No.: 2892295-10-0

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Telomerase-IN-4 is a potent telomerase inhibitor. Telomerase-IN-4 has antiproliferative activity and induces apoptosis^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	17.09 μg/mL Compound: 8e	Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36525642]
MCF7	IC₅₀	9.47 μg/mL Compound: 8e	Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 36525642]

In Vitro

Telomerase-IN-4 (compound 8e; 0.1-100 μg/mL; 72 h) has antitumor effects against both cancer cell lines with IC₅₀ values of 9.47 and 17.09 μg/mL for MCF-7 and A549 cells, respectively^[1].
Telomerase-IN-4 (9.467 μg/mL; 48 h) arrests cell cycle at the S phase and induces apoptosis in MCF-7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MCF-7 and A549 cells
Concentration:

0.1, 1, 10, and 100 μg/mL
Incubation Time:

72 h
Result:

Inhibited cell growth in a dose-dependent manner.

Apoptosis Analysis^[1]

Cell Line:

MCF-7 cells
Concentration:

9.467 μg/mL
Incubation Time:

48 h
Result:

Had an apoptosis percentage of 42.51%.

Cell Cycle Analysis^[1]

Cell Line:

MCF-7 cells
Concentration:

9.467 μg/mL
Incubation Time:

48 h
Result:

Arrested cell cycle at the S phase of cell growth by more than 1.46 folds compared to that of the control.

Western Blot Analysis^[1]

Cell Line:

MCF-7 cells
Concentration:

9.467 μg/mL
Incubation Time:

48 h
Result:

Decreased in ALT and AST levels by 36.12 and 29.77%, respectively.

In Vivo

Telomerase-IN-4 (5 mg/kg; i.p.; three times per week for two weeks; Swiss albino female mice) has anticancer activity and inhibits tumor growth^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss albino female mice (25-30 g)^[1]
Dosage:

5 mg/kg
Administration:

Intraperitoneal injectionthree; times per week for two weeks
Result:

Reduced both the weight and volume of the tumor by 74.34 and 62.12%, respectively.

Chemical Information

CAS No. 2892295-10-0
Molecular Weight 406.52
Formula C₂₁H₁₈N₄OS₂
SMILES

O=C(NC1=C(C#N)C2=C(CCC2)S1)CSC3=NN=C(C=C3)C4=CC=C(C=C4)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations. J Med Chem. 2022 Dec 16. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Get Quote In-stock