Telomerase-IN-9
Telomerase-IN-9 is a potent and selective telomerase inhibitor. Telomerase-IN-9 significantly reduces telomerase activity by binding to hTERT, leading to decreased telomerase function. Telomerase-IN-9 induces apoptosis and inhibits colony formation. Telomerase-IN-9 reduces tumor burden, restores antioxidantbalance, and preserves lung architecture in a Benzo[a]pyrene (HY-107377)-induced lung cancer mouse model. Telomerase-IN-9 can be used for the research of lung cancer.
For research use only. We do not sell to patients.
- Formula: C22H20N4OS
- Molecular Weight:388.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Telomerase-IN-9 (compound 28) (48 h) exhibits potent and selective cytotoxicity against A549, MDA-MB-231, NCI-H460 cells, with IC50s of 0.043, 0.926, and 1.08 μM, resectively, and shows low cytotoxicity on Vero cells with IC50 < 25 μM[1].
Telomerase-IN-9 (5-10 μM, 48 h) induces apoptosis in A549 cells in a dose-dependent manner[1].
Telomerase-IN-9 (10 μM) significantly inhibits telomerase activity in A549 cells, with a fold change of 0.535[1].
Telomerase-IN-9 (3.75-25 μM, 12 days) reduces colony formation in A549 cells in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells
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Concentration:5, 10 μM
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Incubation Time:48 h
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Result:Induced cell death in a dose-dependent manner.
Reduced viability to 76.2% and 62.6% at 5 μM and 10 μM, respectively.
Induced late apoptosis reaching up to 23.1%.
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Cell Line:A549 cells
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Concentration:3.75, 6.25, 12.5, 25 μM
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Incubation Time:12 days
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Result:Demonstrated marked inhibition of colony growth, particularly at higher concentrations (12.5 and 25 μM), where the reduction was statistically significant compared to the control.
Chemical Information
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Molecular Weight 388.49
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Formula C22H20N4OS
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SMILES
COC1=CC2C(NC3=NN=C(C4=CC=CC=C4)S3)C5=CC=CC=C5NC2C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Telomerase-IN-9 Related Classifications
HY-179391 Related Classifications
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