2. Cell Cycle/DNA Damage Apoptosis
  3. Telomerase Apoptosis
  4. RHPS4

RHPS4 

Cat. No.: HY-101089 Purity: 98.62%
COA Handling Instructions

RHPS4 is a potent telomerase inhibitor (IC50 = 0.33 μM). RHPS4 is a DNA damage inducer.

For research use only. We do not sell to patients.

RHPS4 Chemical Structure

RHPS4 Chemical Structure

CAS No. : 390362-78-4

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Based on 1 publication(s) in Google Scholar

RHPS4 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

RHPS4 is a potent telomerase inhibitor (IC50 = 0.33 μM). RHPS4 is a DNA damage inducer[1][2].

IC50 & Target

IC50: 0.33 μM (telomerase in the TRAP assay)[1].
In Vitro

RHPS4 could sensitize tumor cells to anticancer agents that act via disparate mechanisms[1].
RHPS4 (0.5-1 μM, 15 days) induces a senescent-like growth arrest in MCF-7 cells[1].
RHPS4 (1 μM, 4 days) induces phosphorylation of H2AX in transformed and tumor cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RHPS4 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MCF-7, MCF-7 vector control, and MCF-7 c81 cells.
Concentration: 0, 0.2, 0.5, or 1 μM.
Incubation Time: 7 days.
Result: Inhibited cell proliferation.
In Vivo

RHPS4 (15 mg/kg, iv, 15 days) treatment produces a marked inhibition of tumor weight (tumor weight inhibition [TWI] about 80%; P < 0.001) in a very short time, and this effect persists for at least 30 days. A complete tumor response is observed in 80% of mice, and 40% are cured[2].
In all the other tumor xenografts, RHPS4 treatment produces about 50% (P < 0.001) TWI at the nadir of the effect and, more important, results in a delay of tumor growth of about 15 (M14 and PC3) and 10 (HT29 and H460) days[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD-1 male nude (nu/nu) mice, 6–8 weeks old and weighing 22-24 g (H460, CG5 and HT29, PC3 and M14 cancer models)[2].
Dosage: 15 mg/kg.
Administration: IV, daily for 15 consecutive days.
Result: Active as a single agent on all the tumors analyzed. CG5 breast xenografts resulted in the most sensitive tumor.
Molecular Weight

458.48

Appearance

Solid

Formula

C23H20F2N2O4S
CAS No.
SMILES

O=S([O-])(OC)=O.FC1=CC=C2C(C3=[N+](C)C4=C(C=C(C=C4)F)C5=C3C(N2C)=CC(C)=C5)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 1 mg/mL (2.18 mM; ultrasonic and warming and heat to 60°C)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1811 mL 10.9056 mL 21.8112 mL
5 mM --- --- ---
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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RHPS4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

RHPS4390362-78-4RHPS 4RHPS-4TelomeraseApoptosisH460CG5HT29PC3M14breastcancerH2AXInhibitorinhibitorinhibit

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