2. Apoptosis
  3. Apoptosis
  4. Telomerase-IN-5

Telomerase-IN-5 is a potent telomerase inhibitor. Telomerase-IN-5 has antiproliferative activity and induces apoptosis.

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Telomerase-IN-5

Telomerase-IN-5 Chemical Structure

CAS No. : 2892295-16-6

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Telomerase-IN-5 Related Antibodies

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Description

Telomerase-IN-5 is a potent telomerase inhibitor. Telomerase-IN-5 has antiproliferative activity and induces apoptosis[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
63.85 μg/mL
Compound: 9e
Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 36525642]
MCF7 IC50
34.53 μg/mL
Compound: 9e
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 36525642]
In Vitro

Telomerase-IN-5 (compound 9e; 0.1-100 μg/mL; 72 h) has antitumor effects against both cancer cell lines with IC50 values of 34.53 and 63.85 μg/mL for MCF-7 and A549 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Telomerase-IN-5 Related Antibodies

Cell Viability Assay[1]

Cell Line: MCF-7 and A549 cells
Concentration: 0.1, 1, 10, and 100 μg/mL
Incubation Time: 72 h
Result: Inhibited cell growth in a dose-dependent manner.
Molecular Weight

420.55

Formula

C22H20N4OS2
CAS No.
SMILES

O=C(NC1=C(C#N)C2=C(CCCC2)S1)CSC3=NN=C(C4=CC=C(C)C=C4)C=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Telomerase-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Telomerase-IN-52892295-16-6ApoptosisantiproliferativetumorMCF-7A549Inhibitorinhibitorinhibit

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HY-152077
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