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West Nile virus (WNV)

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標的別:	Apoptosis (4) Aurora Kinase (4) Autophagy (2) Bacterial (4) CHIKV (1) Dengue Virus (4) Flavivirus (8) HCV (1) HIV (2) Indoleamine 2,3-Dioxygenase (IDO) (4) Influenza Virus (1) mAChR (4) Parasite (4) Reference Standards (1) Virus Protease (13)
研究分野別:	Cancer (4) Infection (17) Inflammation/Immunology (4) Metabolic Disease (4) Neurological Disease (4)

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製品番号	製品名	Target	研究分野	構造式

HY-N0110

Palmatine chloride 5+ Cited Publications	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-P2260

Tat-beclin 1 5+ Cited Publications	CHIKV Autophagy HIV	Infection
Tat-beclin 1, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV) .

HY-N0110A

Palmatine	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-N0110B

Palmatine hydroxide 5+ Cited Publications	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Palmatine hydroxide is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine hydroxide can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine hydroxide shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-134910

SID-852843	Virus Protease	Infection
SID-852843 is a WNV NS2B-NS3 proteinase inhibitor. SID-852843 can inhibit WNV NS2B-NS3 proteinase activity with IC₅₀ value of 0.105 μM. SID-852843 can be used for the research of virus infection .

HY-P990817

Anti-West Nile/dengue virus E protein Antibody (E60)	Dengue Virus Flavivirus	Infection
Anti-West Nile/dengue virus E protein Antibody (E60) is mouse-derived IgG2a κ type antibody inhibitor, targeting to West Nile/dengue virus E protein. Anti-West Nile/dengue virus E protein Antibody (E60) can cross-neutralize West Nile virus (WNV) and dengue virus (DENV) envelope (E) protein. Anti-West Nile/dengue virus E protein Antibody (E60) can be used for the researches of WNV and DENV infection .

HY-148310

Flaviviruses-IN-2	Virus Protease	Infection
Flaviviruses-IN-2 (compound 78) is a potent flaviviruses inhibitor. Flaviviruses-IN-2 reduces the *WNV* (West Nile virus) protease activity, with inhibition of 56% .

HY-179013

NS2B/NS3-IN-9	Virus Protease Flavivirus Dengue Virus	Infection
NS2B/NS3-IN-9 (Compound 73) is a broad-spectrum, non-competitive anti-Orthoflavivirus lipopeptide inhibitor targeting the NS2B-NS3 protease. NS2B/NS3-IN-9 exhibits IC₅₀ values for Dengue virus DENV2 NS2B-NS3, West Nile virus WNV NS2B-NS3, and Zika virus ZIKV NS2B-NS3 of 2.4, 7.2, and 1.9 μM, respectively. NS2B/NS3-IN-9 also exhibits antiviral activity at the cellular level against DENV2, WNV, and ZIKV, with EC₅₀ values of 4.1, 4.9, and 5.0 μM, respectively. NS2B/NS3-IN-9 has no significant toxicity to cells. NS2B/NS3-IN-9 can be used for the study of anti-Orthoflavivirus .

HY-153076

Flaviviruses-IN-3	Virus Protease	Infection
Flaviviruses-IN-3 (compound 87) is a potent flaviviruse inhibitor. Flaviviruses-IN-3 reduces the *WNV* (West Nile virus) protease activity, with a inhibition of 54% .

HY-P2260A

Tat-beclin 1 TFA	Autophagy HIV	Infection
Tat-beclin 1 TFA, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 TFA decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV) .

HY-N0110R

Palmatine chloride (Standard)	Apoptosis Virus Protease Indoleamine 2,3-Dioxygenase (IDO) Parasite Bacterial Aurora Kinase mAChR Reference Standards	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Palmatine (chloride) (Standard) is the analytical standard of Palmatine (chloride). This product is intended for research and analytical applications. Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

HY-P4209A

Boc-GRR-AMC TFA	Virus Protease	Others
Boc-GRR-AMC (TFA) is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .

HY-P991774

Anti-West Nile virus NS1 Antibody (10NS1)	Flavivirus	Infection
Anti-West Nile virus NS1 Antibody (10NS1) reacts with non-structural protein 1 (NS1) of West Nile virus (WNV). Anti-West Nile virus NS1 Antibody (10NS1) offers significant protection against flaviviral infections in vivo. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978) .

HY-184226A

ASAP-0036543	Virus Protease	Infection
ASAP-0036543 is an orally active *virus* NS2B-NS3 protease inhibitor. ASAP-0036543 exhibits activity againse Zika virus (ZIKV) and West Nile virus (WNV). ASAP-0036543 reduces ZIKV RNA load in plasma and spleen, and inhibits ZIKV and *WNV* replication in mammalian cells. ASAP-0036543 can be used for the research of zika virus infection, west nile virus infection .

HY-P991772

Anti-WNV E protein DIII-LR Antibody (E16)	Flavivirus	Infection
Anti-WNV E protein DIII-LR Antibody (E16) reacts with the domain III lateral ridge (DIII-LR) of the envelope (E) protein of **West Nile Virus (WNV)*. Anti-Mouse CD11b Antibody (5C6) protects mice from WNV* infection. Recommend Isotype Controls: Mouse IgG2b kappa, Isotype Control (HY-P99982) .

HY-156052

CN-716 dihydrochloride	Flavivirus Dengue Virus Virus Protease	Infection
CN-716 dihydrochloride is a reversible covalent flavivirus NS2B·NS3 protease inhibitor with antiviral activity. CN-716 dihydrochloride effectively inhibits the replication of dengue virus (DENV2), West Nile virus (WNV) and Zika virus (ZIKV). The IC₅₀ values of CN-716 dihydrochloride against the proteases of the above three viruses are 0.066 μM, 0.11 μM and 0.25 μM, respectively, while the K_i values against the same proteases are 0.051 μM, 0.082 μM and 0.04 μM, respectively. CN-716 dihydrochloride can be used to study the infection mechanisms of dengue fever, West Nile fever and Zika virus infection .

HY-131379

ZX-2401	Flavivirus Dengue Virus HCV Influenza Virus	Infection
ZX-2401 (Compound 98a) is a 1,3,5-Triazine-based analogue of Purine (HY-34431). ZX-2401 has a significant antiviral activity against viruses of the Flaviviridae family, such as West Nile Virus (WNV), Hepatitis C (HCV), Yellow Fever Virus (YFV), Dengue Virus (DV), Bovine Viral Diarrhea Virus (BVDV) and Banzi Virus (BV) with EC₉₀s of 0.6-10 μg/mL. ZX-2401 significantly reduces virus production with an EC₉₀ of 3.3 mg/mL. ZX-2401 can be used for influenza infections research .

HY-181990

IRBM-Z-1	Virus Protease Flavivirus
IRBM-Z-1 is a non-competitive inhibitor of Zika virus (ZIKV) NS2B-NS3 protease, with an IC₅₀ of 1.8 μM. IRBM-Z-1 also exhibits inhibitory activity against the NS2B-NS3 proteases of T156I-mutated dengue virus 2 (DENV2) and West Nile virus (WNV), with IC₅₀ values of 3.9 μM and 4.7 μM, respectively. IRBM-Z-1 inhibits ZIKV replication, attenuates virus-induced cytopathic effects. IRBM-Z-1 is applicable to research related to ZIKV infection .

HY-181991

IRBM-Z-2	Virus Protease Flavivirus	Infection
IRBM-Z-2 is a non-competitive, orally active Zika virus (ZIKV) NS2B-NS3 protease inhibitor, with IC₅₀ values of 0.04 μM and 3.1 μM against the wild-type and I156T mutant strains, respectively. IRBM-Z-2 exhibits broad-spectrum anti-flavivirus potential, with IC₅₀ values of 2.1 μM and 0.09 μM against the NS2B-NS3 proteases of dengue virus 2 (DENV2) and West Nile virus (WNV), respectively. IRBM-Z-1 inhibits ZIKV replication and alleviates virus-induced cytopathic effects. IRBM-Z-1 can be used in studies related to ZIKV infection .

製品番号	製品名	Target	研究分野

HY-P2260

Tat-beclin 1 5+ Cited Publications	CHIKV Autophagy HIV	Infection
Tat-beclin 1, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV) .

HY-P4209

Boc-GRR-AMC	ペプチド	Others
Boc-GRR-AMC is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .

HY-P2260A

Tat-beclin 1 TFA	Autophagy HIV	Infection
Tat-beclin 1 TFA, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 TFA decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV) .

HY-P4209A

Boc-GRR-AMC TFA	Virus Protease	Others
Boc-GRR-AMC (TFA) is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .

製品番号	製品名	Target	研究分野	Image

HY-P990817

Anti-West Nile/dengue virus E protein Antibody (E60)	Dengue Virus Flavivirus	Infection
Anti-West Nile/dengue virus E protein Antibody (E60) is mouse-derived IgG2a κ type antibody inhibitor, targeting to West Nile/dengue virus E protein. Anti-West Nile/dengue virus E protein Antibody (E60) can cross-neutralize West Nile virus (WNV) and dengue virus (DENV) envelope (E) protein. Anti-West Nile/dengue virus E protein Antibody (E60) can be used for the researches of WNV and DENV infection .

HY-P991774

Anti-West Nile virus NS1 Antibody (10NS1)	Flavivirus	Infection
Anti-West Nile virus NS1 Antibody (10NS1) reacts with non-structural protein 1 (NS1) of West Nile virus (WNV). Anti-West Nile virus NS1 Antibody (10NS1) offers significant protection against flaviviral infections in vivo. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978) .

HY-P991772

Anti-WNV E protein DIII-LR Antibody (E16)	Flavivirus	Infection
Anti-WNV E protein DIII-LR Antibody (E16) reacts with the domain III lateral ridge (DIII-LR) of the envelope (E) protein of **West Nile Virus (WNV)*. Anti-Mouse CD11b Antibody (5C6) protects mice from WNV* infection. Recommend Isotype Controls: Mouse IgG2b kappa, Isotype Control (HY-P99982) .

Palmatine chloride 5+ Cited Publications	Alkaloids Phellodendron amurense Rupr. Classification of Application Fields Rutaceae Plants Isoquinoline Alkaloids Disease Research Fields Cancer	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite
Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

Palmatine	Alkaloids Phellodendron amurense Rupr. Classification of Application Fields Rutaceae Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Source Classification	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite
Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

Palmatine hydroxide 5+ Cited Publications	Alkaloids Phellodendron amurense Rupr. Other Alkaloids Rutaceae Plants Source Classification	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite
Palmatine hydroxide is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine hydroxide can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine hydroxide shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

Palmatine chloride (Standard)	Structural Classification Alkaloids Phellodendron amurense Rupr. Classification of Application Fields Rutaceae Plants Isoquinoline Alkaloids Disease Research Fields Source Classification Cancer	Apoptosis Virus Protease Indoleamine 2,3-Dioxygenase (IDO) Parasite Bacterial Aurora Kinase mAChR Reference Standards
Palmatine (chloride) (Standard) is the analytical standard of Palmatine (chloride). This product is intended for research and analytical applications. Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

Species:	Virus (5)
Tag:	His (5)
Source:	HEK293 (1) P. pastoris (4)

製品番号	Compare	製品名	Species	Source	Image

HY-P74464

	West Nile Virus NS1 Protein (HEK293, His) West Nile virus (WNV) (lineage 1, strain NY99) NS1 Protein	Virus	HEK293
	West Nile Virus NS1 Protein is a glycoprotein among the flavivirus genus. It is found in both membrane-associated and soluble secreted forms. WNV NS1 has an unusual structure-function because it is glycosylated and forms different structures to facilitate different roles intracellularly and extracellularly, including roles in the replication complex, assisting in virus assembly, and complement antagonism. It also plays a role in protective immunity through antibody-mediated cellular cytotoxicity, and anti-NS1 antibodies elicit passive protection in animal models against a virus challenge. West Nile Virus NS1 Protein (HEK293, His) is the recombinant Virus-derived West Nile Virus NS1 protein, expressed by HEK293 , with N-His labeled tag.

HY-P74186

	E/Envelope Protein, West Nile Virus Lineage 2 (120a.a, P.pastoris, His) WNV-E Protein, WNV	Virus	P. pastoris
	E/Envelope Protein, West Nile Virus Lineage 2 (120a.a, P.pastoris, His) is the recombinant Virus-derived E/Envelope protein, expressed by P. pastoris, with C-His labeled tag.

HY-P74187

	E/Envelope Protein, West Nile Virus Lineage 2 (109a.a, P.pastoris, His) WNV-E Protein, WNV	Virus	P. pastoris
	E/Envelope Protein, West Nile Virus Lineage 2 (109a.a, P.pastoris, His) is the recombinant Virus-derived E/Envelope protein, expressed by P. pastoris, with C-His labeled tag.

HY-P74188

	E/Envelope Protein, West Nile virus Lineage 1 (120a.a, P.pastoris, His) WNV-E Protein, WNV	Virus	P. pastoris
	E/Envelope Protein, West Nile virus Lineage 1 (120a.a, P.pastoris, His) is the recombinant Virus-derived E/Envelope protein, expressed by P. pastoris, with C-His labeled tag.

HY-P74189

	E/Envelope Protein, West Nile Virus Lineage 1 (109a.a, P.pastoris, His) WNV-E Protein, WNV	Virus	P. pastoris
	E/Envelope Protein, West Nile Virus Lineage 1 (109a.a, P.pastoris, His) is the recombinant Virus-derived E/Envelope protein, expressed by P. pastoris, with C-His labeled tag.

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