IRBM-Z-1
Based on 1 Customer Validation
IRBM-Z-1 is a non-competitive inhibitor of Zika virus (ZIKV) NS2B-NS3 protease, with an IC50 of 1.8 μM. IRBM-Z-1 also exhibits inhibitory activity against the NS2B-NS3 proteases of T156I-mutated dengue virus 2 (DENV2) and West Nile virus (WNV), with IC50 values of 3.9 μM and 4.7 μM, respectively. IRBM-Z-1 inhibits ZIKV replication, attenuates virus-induced cytopathic effects. IRBM-Z-1 is applicable to research related to ZIKV infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.61%
- CAS 番号: 67629-86-1
- 分子式: C19H17F3N4O2
- 分子量:390.36
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
IRBM-Z-1 (72 h) inhibits the replication of ZIKV replicons in stable Vero cells, with an EC50 of 6.0 μM, and shows no cytotoxicity at concentrations up to 32 μM[1].
IRBM-Z-1 (6 days) inhibits the ZIKV-induced cytopathic effect in Vero cells, with an EC50 of 6.25 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 67629-86-1
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性状 Solid
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分子量 390.36
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分子式 C19H17F3N4O2
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Color White to off-white
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SMILES
CC([N+]1=NOC([N-]C(NC2=CC=CC(C(F)(F)F)=C2)=O)=C1)CC3=CC=CC=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外:
DMSO : ≥ 100 mg/mL (256.17 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
純度とドキュメンテーション
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データシート (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5617 mL | 12.8087 mL | 25.6174 mL | 64.0434 mL |
| 5 mM | 0.5123 mL | 2.5617 mL | 5.1235 mL | 12.8087 mL | |
| 10 mM | 0.2562 mL | 1.2809 mL | 2.5617 mL | 6.4043 mL | |
| 15 mM | 0.1708 mL | 0.8539 mL | 1.7078 mL | 4.2696 mL | |
| 20 mM | 0.1281 mL | 0.6404 mL | 1.2809 mL | 3.2022 mL | |
| 25 mM | 0.1025 mL | 0.5123 mL | 1.0247 mL | 2.5617 mL | |
| 30 mM | 0.0854 mL | 0.4270 mL | 0.8539 mL | 2.1348 mL | |
| 40 mM | 0.0640 mL | 0.3202 mL | 0.6404 mL | 1.6011 mL | |
| 50 mM | 0.0512 mL | 0.2562 mL | 0.5123 mL | 1.2809 mL | |
| 60 mM | 0.0427 mL | 0.2135 mL | 0.4270 mL | 1.0674 mL | |
| 80 mM | 0.0320 mL | 0.1601 mL | 0.3202 mL | 0.8005 mL | |
| 100 mM | 0.0256 mL | 0.1281 mL | 0.2562 mL | 0.6404 mL |
IRBM-Z-1 関連分類
HY-181990 関連分類
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