2. Anti-infection
  3. Virus Protease Flavivirus
  4. IRBM-Z-1

IRBM-Z-1 is a non-competitive inhibitor of Zika virus (ZIKV) NS2B-NS3 protease, with an IC50 of 1.8 μM. IRBM-Z-1 also exhibits inhibitory activity against the NS2B-NS3 proteases of T156I-mutated dengue virus 2 (DENV2) and West Nile virus (WNV), with IC50 values of 3.9 μM and 4.7 μM, respectively. IRBM-Z-1 inhibits ZIKV replication, attenuates virus-induced cytopathic effects. IRBM-Z-1 is applicable to research related to ZIKV infection.

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IRBM-Z-1

IRBM-Z-1 Chemical Structure

CAS No. : 67629-86-1

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IRBM-Z-1 Related Antibodies

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Description

IRBM-Z-1 is a non-competitive inhibitor of Zika virus (ZIKV) NS2B-NS3 protease, with an IC50 of 1.8 μM. IRBM-Z-1 also exhibits inhibitory activity against the NS2B-NS3 proteases of T156I-mutated dengue virus 2 (DENV2) and West Nile virus (WNV), with IC50 values of 3.9 μM and 4.7 μM, respectively. IRBM-Z-1 inhibits ZIKV replication, attenuates virus-induced cytopathic effects. IRBM-Z-1 is applicable to research related to ZIKV infection[1].

In Vitro

IRBM-Z-1 (72 h) inhibits the replication of ZIKV replicons in stable Vero cells, with an EC50 of 6.0 μM, and shows no cytotoxicity at concentrations up to 32 μM[1].
IRBM-Z-1 (6 days) inhibits the ZIKV-induced cytopathic effect in Vero cells, with an EC50 of 6.25 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IRBM-Z-1 Related Antibodies
Molecular Weight

390.36

Formula

C19H17F3N4O2
CAS No.
SMILES

CC([N+]1=NOC([N-]C(NC2=CC=CC(C(F)(F)F)=C2)=O)=C1)CC3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IRBM-Z-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IRBM-Z-167629-86-1Virus ProteaseFlavivirusZika virus (I156T mutant)West Nile virus NS2B-NS3 proteaseZika virus NS2B-NS3 proteaseZIKV repliconZika virus infectionT156I mutant DENV2 NS2B-NS3 proteaseZika virus replicationVero cellsDENV2 NS2B-NS3 proteasestable Vero cellsInhibitorinhibitorinhibit

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