apoptosis dye

Pathways Recommended:	Apoptosis

By Targets:	Apoptosis (12) Fluorescent Dye (8) Akt (1) ATP Synthase (1) Autophagy (2) Bacterial (3) Casein Kinase (1) Caspase (2) Cytochrome P450 (1) Dynamin (1) Environmental Pollutants (2) Fungal (2) Gap Junction Protein (1) Interleukin Related (1) Mitochondrial Metabolism (1) Na+/K+ ATPase (1) NF-κB (2) NO Synthase (1) Parasite (1) Reference Standards (3) Toll-like Receptor (TLR) (2) Virus Protease (1) Wnt (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (2) Infection (6) Inflammation/Immunology (6) Metabolic Disease (1) Neurological Disease (2)

Targets Recommended: Apoptosis Fluorescent Dye ASK1 SNIPERs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15924

Thiazolyl Blue 180+ Cited Publications MTT; Thiazolyl Blue Tetrazolium bromide; Methylthiazolyldiphenyl-tetrazolium bromide	Fluorescent Dye	Others
Thiazolyl Blue (MTT) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis .

HY-N2493

Lawsone 2 Publications Verification	Fungal Apoptosis	Infection Cancer
Lawsone is an orally active naphthoquinone dye that can be isolated from the leaves of Lawsonia inermis. Lawsone can induce *apoptosis*. Lawsone has antibacterial, antitumor and antioxidant activities. Lawsone can be used in anti-tumor drug research .

HY-D0257

Tartrazine 1 Publications Verification Acid Yellow 23; FD&C Yellow No. 5	Environmental Pollutants Fluorescent Dye	Cardiovascular Disease Neurological Disease
Tartrazine (Acid Yellow 23; FD&C Yellow No. 5) is an orally active azo acid dye, orange-yellow powder, soluble in water and turns yellow. Tartrazine is mainly used as a synthetic lemon yellow azo dye for food coloring. Tartrazine is the most stable colorant.Tartrazine induces mitochondria-mediated *Apoptosis*. Tartrazine can cause neurodevelopmental toxicity, cytotoxicity, and genotoxicity .

HY-N6949

Juglone 4 Publications Verification 5-Hydroxy-1,4-naphthalenedione	Bacterial NF-κB Toll-like Receptor (TLR) Apoptosis	Infection Inflammation/Immunology Cancer
Juglone (5-hydroxy-1,4-naphthalenedione) is a yellow dye that can be extracted from Juglans regia. Juglone induces *apoptosis* through the mitochondrial pathway. Juglone has antibacterial and antitumor activity .

HY-N0072

Brazilin 2 Publications Verification	Apoptosis Autophagy	Inflammation/Immunology Cancer
Brazilin is a red dye precursor obtained from the heartwood of several species of tropical hardwoods. Brazilin inhibits the cells proliferation, promotes *apoptosis, and induces autophagy* through the AMPK/mTOR pathway. Brazilin shows chondroprotective and anti-inflammatory activities .

HY-N0354

Anthraquinone 3 Publications Verification	Environmental Pollutants Virus Protease	Infection Metabolic Disease Inflammation/Immunology Cancer
Anthraquinone is used as a precursor for dye formation and agrochemicals, existing in different organisms, such as bacteria, fungi, plants, and some animals. Anthraquinone has biological activities: anticancer, antiinflammatory, diuretic, antiarthritic, antifungal, antibacterial, antimalarial and antioxidant. Anthraquinone also plays an important role in the primary metabolism of plants by acting on the electron transport chain through the inhibition of energy transfer in the photosynthetic process. Anthraquinone can intercalates into DNA and inhibits the topoisomerase II (topo II) enzyme, resulting in cell death via *Apoptosis* .

HY-119751

Hematein 1 Publications Verification	Casein Kinase Akt Wnt Apoptosis	Cancer
Hematein is a oxidation product of hematoxylin acted as a dye . Hematein is an allosteric casein kinase II inhibitor with an IC₅₀ of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases *apoptosis* in lung cancer cells .

HY-139109

IR-783 2 Publications Verification ADS 780WS	Fluorescent Dye Apoptosis Mitochondrial Metabolism ATP Synthase Cytochrome P450 Dynamin	Cancer
IR-783 (ADS 780WS) is a heptamethine cyanine dye. IR-783 induces Mitochondrial membrane potential loss, ATP depletion, mitochondrial permeability transition pore opening, Cytochrome c release and *Apoptosis* in breast cancer cells. IR-783 promotes the translocation of Drp1 from the cytosol to mitochondria. IR-783 increases the expression of mitochondrial fission proteins such as MFF and Fission-1. IR-783 possesses imaging, cancer-targeting and anticancer properties. IR-783 exerts anticancer effects against breast cancer. IR-783 can be used in breast cancer-related research .

HY-N10424

Brazilein 2 Publications Verification	Na+/K+ ATPase Apoptosis Interleukin Related NO Synthase Bacterial Parasite	Cardiovascular Disease Infection Neurological Disease Inflammation/Immunology
Brazilein is a compound with anti-inflammatory and neuroprotective activities, with an IC₅₀ of 500 μM against guinea pig Na ⁺,K ⁺-ATPase. Brazilein reduces iNOS mRNA expression, thereby inhibiting nitric oxide production in immune cells. Brazilein suppresses inflammatory responses by reducing the mRNA expression of TNF-α and IL-6, but has no effect on IL-1β expression. Brazilein reduces the cerebral infarction volume and improves the neurological function scores of rats with cerebral ischemia-reperfusion injury. Brazilein induces *apoptosis* of splenic lymphocytes in mice. Brazilein inhibits humoral immune responses in mice, and causes thymus and spleen atrophy as well as body weight loss in mice. Brazilein also possesses antimalarial and antibacterial activities. Brazilein is also a red dye. Brazilein can be used in studies related to the infection, nervous system, cardiovascular system and inflammatory diseases .

HY-P4403

Z-DEVD-R110 (Z-Asp-Glu-Val-Asp)₂-Rhodamine 110	Fluorescent Dye Apoptosis Caspase	Others
Z-DEVD-R110 ((Z-Asp-Glu-Val-Asp)₂-Rhodamine 110) is a fluorogenic caspase-3/7 substrate. Z-DEVD-R110 can be used to detect apoptosis. Z-DEVD-R110 is a rhodamine derivative with two four–amino acid (DEVD) peptides linked to the fuorophore .

HY-N2493R

Lawsone (Standard)	Reference Standards Fungal Apoptosis	Infection Cancer
Lawsone is an orally active naphthoquinone dye that can be isolated from the leaves of Lawsonia inermis. Lawsone can induce apoptosis. Lawsone has antibacterial, antitumor and antioxidant activities. Lawsone can be used in anti-tumor drug research .

HY-N6949R

Juglone (Standard) 5-Hydroxy-1,4-naphthalenedione (Standard)	Reference Standards Bacterial NF-κB Toll-like Receptor (TLR) Apoptosis	Infection Inflammation/Immunology Cancer
Juglone (Standard) is the analytical standard of Juglone. This product is intended for research and analytical applications. Juglone (5-hydroxy-1,4-naphthalenedione) is a yellow dye that can be extracted from Juglans regia. Juglone induces apoptosis through the mitochondrial pathway. Juglone has antibacterial and antitumor activity .

HY-N0072R

Brazilin (Standard)	Reference Standards Apoptosis Autophagy	Inflammation/Immunology Cancer
Brazilin (Standard) is the analytical standard of Brazilin. This product is intended for research and analytical applications. Brazilin is a red dye precursor obtained from the heartwood of several species of tropical hardwoods. Brazilin inhibits the cells proliferation, promotes apoptosis, and induces autophagy through the AMPK/mTOR pathway. Brazilin shows chondroprotective and anti-inflammatory activities .

HY-117445

Oxazole yellow	Fluorescent Dye	Others
Oxazole yellow is a cyanine dye composed of benzoxazole and quinoline rings connected by a linker. It is almost non-luminescent in water, but its green fluorescence is significantly enhanced after intercalation in double-stranded DNA. Oxazole yellow can be used to detect cell *apoptosis* .

HY-145499

XTT sodium hydrate	Fluorescent Dye	Others
XTT is a cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator. It is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis.

HY-14584A

PQ-1 succinate	Gap Junction Protein Apoptosis Caspase	Others
PQ-1 succinate is an inhibitor for gap junction, which suppresses the gap junction dye transfer activity in retinal neurosensory R28 cells, and inhibits the CoCl₂-induced ischemic *apoptosis* in retinal cell .

HY-W011998

Triphenylamine N,N-Diphenylbenzenamine	Apoptosis Fluorescent Dye	Others
Triphenylamine (N,N-Diphenylbenzenamine) is a highly fluorescent compound. Triphenylamine can induce *apoptosis. Triphenylamine can be used as a fluorescent dye* and is also used in photodynamic therapy research .

HY-DY1086

Thiazolyl Blue (solution) MTT (solution); Thiazolyl Blue Tetrazolium bromide (solution); Methylthiazolyldiphenyl-tetrazolium bromide (solution)	Fluorescent Dye	Others
Thiazolyl Blue (solution) (MTT (solution)) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis . Solvent and concentration: PBS: 5 mg/mL

Cat. No.	Product Name	Type

HY-15924

Thiazolyl Blue 180+ Cited Publications MTT; Thiazolyl Blue Tetrazolium bromide; Methylthiazolyldiphenyl-tetrazolium bromide	Fluorescent Dyes
Thiazolyl Blue (MTT) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis .

HY-D0257

Tartrazine 1 Publications Verification Acid Yellow 23; FD&C Yellow No. 5	Fluorescent Dyes
Tartrazine (Acid Yellow 23; FD&C Yellow No. 5) is an orally active azo acid dye, orange-yellow powder, soluble in water and turns yellow. Tartrazine is mainly used as a synthetic lemon yellow azo dye for food coloring. Tartrazine is the most stable colorant.Tartrazine induces mitochondria-mediated *Apoptosis*. Tartrazine can cause neurodevelopmental toxicity, cytotoxicity, and genotoxicity .

Tartrazine

1 Publications Verification

Acid Yellow 23; FD&C Yellow No. 5

Fluorescent Dyes

Tartrazine (Acid Yellow 23; FD&C Yellow No. 5) is an orally active azo acid dye, orange-yellow powder, soluble in water and turns yellow. Tartrazine is mainly used as a synthetic lemon yellow azo dye for food coloring. Tartrazine is the most stable colorant.Tartrazine induces mitochondria-mediated Apoptosis. Tartrazine can cause neurodevelopmental toxicity, cytotoxicity, and genotoxicity .

HY-145499

XTT sodium hydrate	Fluorescent Dyes
XTT is a cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator. It is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis.

HY-DY1086

Thiazolyl Blue (solution) MTT (solution); Thiazolyl Blue Tetrazolium bromide (solution); Methylthiazolyldiphenyl-tetrazolium bromide (solution)	Fluorescent Dyes
Thiazolyl Blue (solution) (MTT (solution)) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis . Solvent and concentration: PBS: 5 mg/mL

Thiazolyl Blue (solution)

MTT (solution); Thiazolyl Blue Tetrazolium bromide (solution); Methylthiazolyldiphenyl-tetrazolium bromide (solution)

Fluorescent Dyes

Thiazolyl Blue (solution) (MTT (solution)) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis .
Solvent and concentration: PBS: 5 mg/mL

Cat. No.	Product Name	Type

HY-139109

IR-783 2 Publications Verification ADS 780WS	Biochemical Assay Reagents
IR-783 (ADS 780WS) is a heptamethine cyanine dye. IR-783 induces Mitochondrial membrane potential loss, ATP depletion, mitochondrial permeability transition pore opening, Cytochrome c release and *Apoptosis* in breast cancer cells. IR-783 promotes the translocation of Drp1 from the cytosol to mitochondria. IR-783 increases the expression of mitochondrial fission proteins such as MFF and Fission-1. IR-783 possesses imaging, cancer-targeting and anticancer properties. IR-783 exerts anticancer effects against breast cancer. IR-783 can be used in breast cancer-related research .

IR-783

2 Publications Verification

ADS 780WS

Biochemical Assay Reagents

IR-783 (ADS 780WS) is a heptamethine cyanine dye. IR-783 induces Mitochondrial membrane potential loss, ATP depletion, mitochondrial permeability transition pore opening, Cytochrome c release and Apoptosis in breast cancer cells. IR-783 promotes the translocation of Drp1 from the cytosol to mitochondria. IR-783 increases the expression of mitochondrial fission proteins such as MFF and Fission-1. IR-783 possesses imaging, cancer-targeting and anticancer properties. IR-783 exerts anticancer effects against breast cancer. IR-783 can be used in breast cancer-related research .

Cat. No.	Product Name	Target	Research Area

HY-P4403

Z-DEVD-R110 (Z-Asp-Glu-Val-Asp)₂-Rhodamine 110	Fluorescent Dye Apoptosis Caspase	Others
Z-DEVD-R110 ((Z-Asp-Glu-Val-Asp)₂-Rhodamine 110) is a fluorogenic caspase-3/7 substrate. Z-DEVD-R110 can be used to detect apoptosis. Z-DEVD-R110 is a rhodamine derivative with two four–amino acid (DEVD) peptides linked to the fuorophore .

Cat. No.	Product Name

HY-K1092

*YO-PRO-1/PI Apoptosis* and Necrosis Detection Kit**
MCE YO-PRO-1/PI Apoptosis and Necrosis Detection Kit is a dual-fluorescence method based on the green fluorescent dye YO-PRO-1 (YP1) and the red fluorescent dye Propidium Iodide (PI) for detecting cell apoptosis and necrosis.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2493

Lawsone 2 Publications Verification	Infection Quinones Lawsonia inermis L. Lythraceae Classification of Application Fields Plants Naphthalene Quinones Disease Research Fields Source Classification	Fungal Apoptosis
Lawsone is an orally active naphthoquinone dye that can be isolated from the leaves of Lawsonia inermis. Lawsone can induce *apoptosis*. Lawsone has antibacterial, antitumor and antioxidant activities. Lawsone can be used in anti-tumor drug research .

HY-N6949

Juglone 4 Publications Verification 5-Hydroxy-1,4-naphthalenedione	Infection Quinones Classification of Application Fields Juglandaceae Anti-aging Juglans regia Linn. Plants Naphthalene Quinones Disease Research Fields Source Classification	Bacterial NF-κB Toll-like Receptor (TLR) Apoptosis
Juglone (5-hydroxy-1,4-naphthalenedione) is a yellow dye that can be extracted from Juglans regia. Juglone induces *apoptosis* through the mitochondrial pathway. Juglone has antibacterial and antitumor activity .

HY-N0072

Brazilin 2 Publications Verification	Natural Products Classification of Application Fields Leguminosae Caesalpinia sappan L. Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis Autophagy
Brazilin is a red dye precursor obtained from the heartwood of several species of tropical hardwoods. Brazilin inhibits the cells proliferation, promotes *apoptosis, and induces autophagy* through the AMPK/mTOR pathway. Brazilin shows chondroprotective and anti-inflammatory activities .

HY-N0354

Anthraquinone 3 Publications Verification	Seeds of Cassia tora Linn. Quinones Structural Classification other families Classification of Application Fields Leguminosae Anthraquinones Other Diseases Plants Disease Research Fields Source Classification	Environmental Pollutants Virus Protease
Anthraquinone is used as a precursor for dye formation and agrochemicals, existing in different organisms, such as bacteria, fungi, plants, and some animals. Anthraquinone has biological activities: anticancer, antiinflammatory, diuretic, antiarthritic, antifungal, antibacterial, antimalarial and antioxidant. Anthraquinone also plays an important role in the primary metabolism of plants by acting on the electron transport chain through the inhibition of energy transfer in the photosynthetic process. Anthraquinone can intercalates into DNA and inhibits the topoisomerase II (topo II) enzyme, resulting in cell death via *Apoptosis* .

HY-N10424

Brazilein 2 Publications Verification	Structural Classification Classification of Application Fields Leguminosae Caesalpinia sappan L. Phenols Polyphenols Pigments Plants Inflammation/Immunology Disease Research Fields Source Classification Food Research	Na+/K+ ATPase Apoptosis Interleukin Related NO Synthase Bacterial Parasite
Brazilein is a compound with anti-inflammatory and neuroprotective activities, with an IC₅₀ of 500 μM against guinea pig Na ⁺,K ⁺-ATPase. Brazilein reduces iNOS mRNA expression, thereby inhibiting nitric oxide production in immune cells. Brazilein suppresses inflammatory responses by reducing the mRNA expression of TNF-α and IL-6, but has no effect on IL-1β expression. Brazilein reduces the cerebral infarction volume and improves the neurological function scores of rats with cerebral ischemia-reperfusion injury. Brazilein induces *apoptosis* of splenic lymphocytes in mice. Brazilein inhibits humoral immune responses in mice, and causes thymus and spleen atrophy as well as body weight loss in mice. Brazilein also possesses antimalarial and antibacterial activities. Brazilein is also a red dye. Brazilein can be used in studies related to the infection, nervous system, cardiovascular system and inflammatory diseases .

HY-N2493R

Lawsone (Standard)	Quinones Structural Classification Lawsonia inermis L. Lythraceae Plants Naphthalene Quinones Source Classification	Reference Standards Fungal Apoptosis
Lawsone is an orally active naphthoquinone dye that can be isolated from the leaves of Lawsonia inermis. Lawsone can induce apoptosis. Lawsone has antibacterial, antitumor and antioxidant activities. Lawsone can be used in anti-tumor drug research .

HY-N6949R

Juglone (Standard) 5-Hydroxy-1,4-naphthalenedione (Standard)	Quinones Structural Classification Juglandaceae Juglans regia Linn. Plants Naphthalene Quinones Source Classification	Reference Standards Bacterial NF-κB Toll-like Receptor (TLR) Apoptosis
Juglone (Standard) is the analytical standard of Juglone. This product is intended for research and analytical applications. Juglone (5-hydroxy-1,4-naphthalenedione) is a yellow dye that can be extracted from Juglans regia. Juglone induces apoptosis through the mitochondrial pathway. Juglone has antibacterial and antitumor activity .

HY-N0072R

Brazilin (Standard)	Structural Classification Natural Products Leguminosae Caesalpinia sappan L. Phenols Polyphenols Plants Source Classification	Reference Standards Apoptosis Autophagy
Brazilin (Standard) is the analytical standard of Brazilin. This product is intended for research and analytical applications. Brazilin is a red dye precursor obtained from the heartwood of several species of tropical hardwoods. Brazilin inhibits the cells proliferation, promotes apoptosis, and induces autophagy through the AMPK/mTOR pathway. Brazilin shows chondroprotective and anti-inflammatory activities .

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Fluorescent Dyes

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apoptosis dye

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

MCE Kits

NaturalProducts

Natural
Products