2. Others Apoptosis Metabolic Enzyme/Protease Membrane Transporter/Ion Channel Cytoskeleton
  3. Fluorescent Dye Apoptosis Mitochondrial Metabolism ATP Synthase Cytochrome P450 Dynamin
  4. IR-783

IR-783 (ADS 780WS) is a heptamethine cyanine dye. IR-783 induces Mitochondrial membrane potential loss, ATP depletion, mitochondrial permeability transition pore opening, Cytochrome c release and Apoptosis in breast cancer cells. IR-783 promotes the translocation of Drp1 from the cytosol to mitochondria. IR-783 increases the expression of mitochondrial fission proteins such as MFF and Fission-1. IR-783 possesses imaging, cancer-targeting and anticancer properties. IR-783 exerts anticancer effects against breast cancer. IR-783 can be used in breast cancer-related research.

For research use only. We do not sell to patients.

IR-783

IR-783 Chemical Structure

CAS No. : 115970-66-6

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Based on 2 publication(s) in Google Scholar

IR-783 Related Antibodies

Top Publications Citing Use of Products

View All Cytochrome P450 Isoform Specific Products:

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

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Description

IR-783 (ADS 780WS) is a heptamethine cyanine dye. IR-783 induces Mitochondrial membrane potential loss, ATP depletion, mitochondrial permeability transition pore opening, Cytochrome c release and Apoptosis in breast cancer cells. IR-783 promotes the translocation of Drp1 from the cytosol to mitochondria. IR-783 increases the expression of mitochondrial fission proteins such as MFF and Fission-1. IR-783 possesses imaging, cancer-targeting and anticancer properties. IR-783 exerts anticancer effects against breast cancer. IR-783 can be used in breast cancer-related research[1].

In Vitro

IR-783 (20-100 μM; 24 h for membrane potential assays) induces intracellular ATP depletion and loss of mitochondrial membrane potential in breast cancer MDA-MB-231 cells[1].
IR-783 (5-120 μM; 6-72 h) selectively inhibits the viability of breast cancer MDA-MB-231 cells in a dose- and time-dependent manner, but exerts no effect on normal hepatocyte LO2 cells[1].
IR-783 (20-100 μM; 24 h) induces apoptosis in breast cancer MDA-MB-231 cells in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IR-783 Related Antibodies

Cell Viability Assay[1]

Cell Line: human breast cancer MDA-MB-231 cells, human normal hepatocyte LO2 cells
Concentration: 5-120 μM (24 h incubation); 40 μM (time-course incubation)
Incubation Time: 6-72 h (40 μM concentration); 24 h (5-120 μM concentrations)
Result: Decreased MDA-MB-231 cell viability in a dose- and time-dependent manner, with significant reductions at all tested concentrations and time points relative to control.
Showed no apparent effect on LO2 cell viability even at 120 μM.

Apoptosis Analysis[1]

Cell Line: human breast cancer MDA-MB-231 cells
Concentration: 20-100 μM
Incubation Time: 24 h
Result: Increased the percentage of apoptotic MDA-MB-231 cells in a dose-dependent manner.
Increased cleaved-caspase-3 levels in a dose-dependent fashion.
Increased cleaved-poly ADP-ribose polymerase (C-PARP) levels relative to control.

In Vivo

IR-783 (20 mg/kg; i.v.; daily; 4 weeks) significantly inhibits MDA-MB-231 xenograft tumour growth (P < .05) via induction of mitochondrial translocation of Drp1 and tumour cell apoptosis, with low observed liver and kidney toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice (female, 5 weeks old)[1]
Dosage: 20 mg/kg
Administration: i.v.; daily; 4 weeks
Result: Inhibited tumour growth significantly after 3 weeks of exposure compared to controls (P < .05).
Showed no statistically significant changes in body weight compared to controls.
Induced no morphological differences in liver and kidney tissues, indicating low liver and kidney toxicity.
Increased numbers of TUNEL-positive cells in tumour tissue.
Increased immunoreactivity for cleaved-caspase-3 in tumour tissue.
Increased Drp1 expression in mitochondrial fractions of tumour tissue.
Increased colocalization of Drp1 and the mitochondrial marker TOM20 in tumour tissue.
Molecular Weight

749.35

Formula

C38H46ClN2NaO6S2
CAS No.
Appearance

Solid

Color

Green to dark green

SMILES

O=[S](CCCCN(/C1=C\C=C(CCC2)\C(Cl)=C2/C=C/C(C3(C)C)=[N+](C4=CC=CC=C34)CCCC[S](=O)([O-])=O)C5=CC=CC=C5C1(C)C)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 116.67 mg/mL (155.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3345 mL 6.6725 mL 13.3449 mL
5 mM 0.2669 mL 1.3345 mL 2.6690 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.87%

SDS (393 KB)

COA (260 KB) HNMR (139 KB) LCMS (87 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3345 mL 6.6724 mL 13.3449 mL 33.3622 mL
5 mM 0.2669 mL 1.3345 mL 2.6690 mL 6.6724 mL
10 mM 0.1334 mL 0.6672 mL 1.3345 mL 3.3362 mL
15 mM 0.0890 mL 0.4448 mL 0.8897 mL 2.2241 mL
20 mM 0.0667 mL 0.3336 mL 0.6672 mL 1.6681 mL
25 mM 0.0534 mL 0.2669 mL 0.5338 mL 1.3345 mL
30 mM 0.0445 mL 0.2224 mL 0.4448 mL 1.1121 mL
40 mM 0.0334 mL 0.1668 mL 0.3336 mL 0.8341 mL
50 mM 0.0267 mL 0.1334 mL 0.2669 mL 0.6672 mL
60 mM 0.0222 mL 0.1112 mL 0.2224 mL 0.5560 mL
80 mM 0.0167 mL 0.0834 mL 0.1668 mL 0.4170 mL
100 mM 0.0133 mL 0.0667 mL 0.1334 mL 0.3336 mL
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IR-783 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IR-783115970-66-6ADS 780WSIR783IR 783Fluorescent DyeApoptosisMitochondrial MetabolismATP SynthaseCytochrome P450DynaminCYPscytochrome cbreast cancerMFFOPA1apoptosisMfn1MDA-MB-231 cellsFis1Drp1mitochondriaInhibitorinhibitorinhibit

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