Search Result

Results for "

fungal secondary metabolite

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Metabolite (2) Endogenous Metabolite (11) Fungal (6) Antibiotic (1) Apoptosis (1) Autophagy (1) Bacterial (5) Dipeptidyl Peptidase (1) Drug Derivative (1) Phosphatase (1) Ras (1)
By Research Areas:	Cancer (3) Infection (9) Inflammation/Immunology (2) Metabolic Disease (1)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Targets Recommended: Fungal Drug Metabolite Endogenous Metabolite

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N8541

Endocrocin	Endogenous Metabolite	Inflammation/Immunology
Endocrocin, an anthraquinone, is a fungal secondary metabolite. Endocrocin is a potent chemotaxis inhibitor with immunosuppressive properties .

HY-134666A

Dioctatin A hydrochloride	Dipeptidyl Peptidase Fungal Bacterial	Infection
Dioctatin A hydrochloride is a metabolite of Streptomyces and an inhibitor of human dipeptidyl aminopeptidase II. Dioctatin A hydrochloride can inhibit aflatoxin production by Aspergillus parasiticus with an IC₅₀ of 4.0 μM. Dioctatin A hydrochloride can reduce the mRNA levels of aflatoxin biosynthetic genes and the regulatory gene aflR, inhibit conidiation and decrease the mRNA level of the brlA gene, and also promote kojic acid production. In addition, Dioctatin A hydrochloride can inhibit sterigmatocystin production. Dioctatin A hydrochloride has pleiotropic regulatory effects on the production and differentiation of fungal secondary metabolites .

HY-118100

Cyclo(Tyr-Val) Cyclo(L-Tyr-L-Val)	Drug Metabolite	Others
Cyclo(Tyr-Val) (Cyclo(L-Tyr-L-Val)) is a diketopiperazine secondary fungal metabolite originally isolated from N. gilva.

HY-N12106

Neosartoricin Fumicycline	Endogenous Metabolite Fungal	Infection
Neosartoricin (Fumicycline) (Compound 3), a prenylated anthracenone, is a microbial secondary metabolite. Neosartoricin can be isolated from Aspergillus fumigatus and Neosartorya fischeri. Neosartoricin has immunosuppressive activity, and significantly inhibits T-cell proliferative activity with an IC₅₀ of 3 μM. Neosartoricin may be beneficial to fungal defense, facilitating infection through suppressing the host adaptive immunity without involvement of primary virulence .

HY-168756

Byssochlamic acid	Fungal	Infection
Byssochlamic acid is a secondary metabolite produced by fungal metabolism .

HY-119328

Pestalotin	Endogenous Metabolite	Others
Pestalotin, a fungal lactone, is a secondary metabolite of endophytic fungus Pestalotiopsis microspore .

HY-129493

Lateropyrone	Bacterial Antibiotic Endogenous Metabolite	Infection
Lateropyrone is a type of pyranone antibiotic that can inhibit Gram-negative bacteria, and it's a secondary metabolite produced by the oat fungal pathogen .

HY-N7291

Tryprostatin A	Others	Others
Tryprostatin A is an inhibitor of the mammalian cell cycle. Tryprostatins A can be isolated from the secondary metabolites of a marine fungal strain BM939 .

HY-121532

(-)-Rasfonin	Ras Apoptosis Autophagy	Cancer
(-)-Rasfonin is a fungal secondary metabolite and inhibits small G proteins Ras. (-)-Rasfonin induces apoptosis, necrosis and autophagy in ACHN cells (a renal carcinoma cell line) .

HY-N16415

Deoxyfunicone	Phosphatase	Inflammation/Immunology
Deoxyfunicone is a secondary fungal metabolite that inhibits PTP1B activity by binding to the active site of the enzyme with an IC₅₀ value of 24.3µM. Deoxyfunicone has anti-inflammatory activity .

HY-121184

Epicoccamide	Endogenous Metabolite	Others
Epicoccamide, a tetramic acid derivative, is secondary metabolite from Epicoccum purpurascens .

HY-N10270

Verrucofortine	Endogenous Metabolite	Others
Verrucofortine, a fungal metabolite, is an alkaloid derived from tryptophan and leucine .

HY-178088

L-731120	Fungal Drug Derivative Drug Metabolite	Infection Metabolic Disease
L-731120 is an alkyl citrate zargozaga acid A analogue, which is secondary metabolite produced by fungal fermentation. L-731120 shows inhibitory activity against squalene synthase (SQS) (IC₅₀ = 260 nM). L-731120 can inhibit the synthesis of cholesterol in the liver. L-731120 can be used for the research of infection and metabolic disease, such as hypercholesterolemia .

HY-163113

Anticancer agent 180	Endogenous Metabolite	Cancer
Anticancer agent 180 (compound 4) is a secondary metabolite present in fungal strains and extracted through physical interaction with Streptomyces sp. Anticancer agent 180 has potential anti-tumor activity and can inhibit the migration of MDA-MB-231 breast cancer cells .

HY-N14063

Cycloleucomelone	Others	Others
Cycloleucomelone, a secondary metabolite, is a fungal pigment .

HY-N20622

Terrestric acid	Endogenous Metabolite	Others
Terrestric acid is a secondary metabolite and fungal toxin produced by various fungi, primarily found in Penicillium species. Terrestric acid induces early cell aging in Penicillium aurantiogriseum .

HY-N9717

Herbaridine B	Endogenous Metabolite	Infection
Herbaridine B is a potential fungal secondary metabolite that can be extracted from the fungus Anteaglonium FL0768. This fungus was isolated as an endophyte from the photosynthetic tissue of Selaginella arenicola .

HY-N11685

(±)-Lomatin Xanthogalol	Bacterial Fungal	Infection
(±)-Lomatin (Xanthogalol) (Compound 10) is a coumarin-type secondary metabolite. (±)-Lomatin can be found in Coleonema album. (±)-Lomatin can be used for the research of bacterial infections, mycobacterial infections, and fungal infections .

HY-N16428

Neoaspergillic acid NSC 356436	Endogenous Metabolite Fungal Bacterial	Infection Cancer
Neoaspergillic acid (NSC 356436) (Compound 2) is a microbial secondary metabolite. Neoaspergillic acid can be isolated from the endophytic fungus Aspergillus sp. SPH2. Neoaspergillic acid has potent antifungal activity against Alternaria alternata, Botrytis cinerea and Fusarium oxysporum. Neoaspergillic acid appears during the exponential phase of fungal growth. Neoaspergillic acid also antitumor and antibacterial effects .

HY-N19641

Dichlorodiaporthin Dichlorodiaportin	Bacterial Endogenous Metabolite	Infection
Dichlorodiaporthin (Dichlorodiaportin) is an isocoumarin metabolite found in cultures of Penicillium nalgiovense. Dichlorodiaporthin acts as an antibacterial agent against various bacterial species .

Cat. No.	Product Name

HY-L253

Fungal-Sourced Compound Library	88 compounds
For thousands of years, natural products have always been an important source for drug discovery. Fungi, due to their unique and diverse secondary metabolic capabilities, have become a valuable resource for natural active molecules. Since the discovery of penicillin, natural products derived from fungi have demonstrated significant application value in areas such as anti-infection, anti-tumor, immune regulation, and metabolic disease research. A large number of clinical drugs, such as antibiotics, immunosuppressants, and lipid-lowering drugs, are derived from fungal metabolites or their structurally optimized derivatives. MCE fungal-derived compound library contains 88 structurally diverse and bioactive fungal natural products and their derivatives. It can be widely applied in various research fields such as antibacterial, anti-tumor, anti-inflammatory, immune regulation, epigenetics, and cell signaling pathways, providing high-quality tools for natural product drug development and high-throughput screening.

Fungal-Sourced Compound Library

88 compounds

For thousands of years, natural products have always been an important source for drug discovery. Fungi, due to their unique and diverse secondary metabolic capabilities, have become a valuable resource for natural active molecules. Since the discovery of penicillin, natural products derived from fungi have demonstrated significant application value in areas such as anti-infection, anti-tumor, immune regulation, and metabolic disease research. A large number of clinical drugs, such as antibiotics, immunosuppressants, and lipid-lowering drugs, are derived from fungal metabolites or their structurally optimized derivatives.

MCE fungal-derived compound library contains 88 structurally diverse and bioactive fungal natural products and their derivatives. It can be widely applied in various research fields such as antibacterial, anti-tumor, anti-inflammatory, immune regulation, epigenetics, and cell signaling pathways, providing high-quality tools for natural product drug development and high-throughput screening.

Endocrocin	Quinones Microorganisms Source Classification	Endogenous Metabolite
Endocrocin, an anthraquinone, is a fungal secondary metabolite. Endocrocin is a potent chemotaxis inhibitor with immunosuppressive properties .

Neosartoricin Fumicycline	Microorganisms Phenols Polyphenols Source Classification	Endogenous Metabolite Fungal
Neosartoricin (Fumicycline) (Compound 3), a prenylated anthracenone, is a microbial secondary metabolite. Neosartoricin can be isolated from Aspergillus fumigatus and Neosartorya fischeri. Neosartoricin has immunosuppressive activity, and significantly inhibits T-cell proliferative activity with an IC₅₀ of 3 μM. Neosartoricin may be beneficial to fungal defense, facilitating infection through suppressing the host adaptive immunity without involvement of primary virulence .

Pestalotin	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Disease Research Fields Source Classification	Endogenous Metabolite
Pestalotin, a fungal lactone, is a secondary metabolite of endophytic fungus Pestalotiopsis microspore .

Lateropyrone	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial Antibiotic Endogenous Metabolite
Lateropyrone is a type of pyranone antibiotic that can inhibit Gram-negative bacteria, and it's a secondary metabolite produced by the oat fungal pathogen .

Tryprostatin A	Alkaloids Microorganisms Other Alkaloids Source Classification	Others
Tryprostatin A is an inhibitor of the mammalian cell cycle. Tryprostatins A can be isolated from the secondary metabolites of a marine fungal strain BM939 .

(-)-Rasfonin	Monophenols Microorganisms Classification of Application Fields Phenols Disease Research Fields Cancer Source Classification	Ras Apoptosis Autophagy
(-)-Rasfonin is a fungal secondary metabolite and inhibits small G proteins Ras. (-)-Rasfonin induces apoptosis, necrosis and autophagy in ACHN cells (a renal carcinoma cell line) .

Deoxyfunicone	Natural Products Microorganisms Source Classification	Phosphatase
Deoxyfunicone is a secondary fungal metabolite that inhibits PTP1B activity by binding to the active site of the enzyme with an IC₅₀ value of 24.3µM. Deoxyfunicone has anti-inflammatory activity .

Epicoccamide	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Other Diseases Disease Research Fields Source Classification	Endogenous Metabolite
Epicoccamide, a tetramic acid derivative, is secondary metabolite from Epicoccum purpurascens .

Verrucofortine	Alkaloids Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Indole Alkaloids Source Classification	Endogenous Metabolite
Verrucofortine, a fungal metabolite, is an alkaloid derived from tryptophan and leucine .

Anticancer agent 180	Microorganisms Phenols Source Classification	Endogenous Metabolite
Anticancer agent 180 (compound 4) is a secondary metabolite present in fungal strains and extracted through physical interaction with Streptomyces sp. Anticancer agent 180 has potential anti-tumor activity and can inhibit the migration of MDA-MB-231 breast cancer cells .

Cycloleucomelone	Microorganisms Antibiotics Other Antibiotics Source Classification	Others
Cycloleucomelone, a secondary metabolite, is a fungal pigment .

Terrestric acid	Structural Classification Natural Products Microorganisms Source Classification	Endogenous Metabolite
Terrestric acid is a secondary metabolite and fungal toxin produced by various fungi, primarily found in Penicillium species. Terrestric acid induces early cell aging in Penicillium aurantiogriseum .

Herbaridine B	Quinones Structural Classification Microorganisms Benzene Quinones Source Classification	Endogenous Metabolite
Herbaridine B is a potential fungal secondary metabolite that can be extracted from the fungus Anteaglonium FL0768. This fungus was isolated as an endophyte from the photosynthetic tissue of Selaginella arenicola .

(±)-Lomatin Xanthogalol	Structural Classification Natural Products Rutaceae Coumarins Phenylpropanoids Plants Coleonema album (Thunb.) Bartl. & H.L.Wendl. Source Classification	Bacterial Fungal
(±)-Lomatin (Xanthogalol) (Compound 10) is a coumarin-type secondary metabolite. (±)-Lomatin can be found in Coleonema album. (±)-Lomatin can be used for the research of bacterial infections, mycobacterial infections, and fungal infections .

Neoaspergillic acid NSC 356436	Natural Products Microorganisms Source Classification	Endogenous Metabolite Fungal Bacterial
Neoaspergillic acid (NSC 356436) (Compound 2) is a microbial secondary metabolite. Neoaspergillic acid can be isolated from the endophytic fungus Aspergillus sp. SPH2. Neoaspergillic acid has potent antifungal activity against Alternaria alternata, Botrytis cinerea and Fusarium oxysporum. Neoaspergillic acid appears during the exponential phase of fungal growth. Neoaspergillic acid also antitumor and antibacterial effects .

Dichlorodiaporthin Dichlorodiaportin	Structural Classification Natural Products Monophenols Microorganisms Phenols Source Classification	Bacterial Endogenous Metabolite
Dichlorodiaporthin (Dichlorodiaportin) is an isocoumarin metabolite found in cultures of Penicillium nalgiovense. Dichlorodiaporthin acts as an antibacterial agent against various bacterial species .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks