Neoaspergillic acid
Neoaspergillic acid (NSC 356436) (Compound 2) is a microbial secondary metabolite. Neoaspergillic acid can be isolated from the endophytic fungus Aspergillus sp. SPH2. Neoaspergillic acid has potent antifungal activity against Alternaria alternata, Botrytis cinerea and Fusarium oxysporum. Neoaspergillic acid appears during the exponential phase of fungal growth. Neoaspergillic acid also antitumor and antibacterial effects.
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- CAS No.: 2152-59-2
- 화학식: C12H20N2O2
- 분자량:224.30
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
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Biological Activity
제품 설명
Chemical Information
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CAS No. 2152-59-2
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분자량 224.30
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화학식 C12H20N2O2
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SMILES
[O-][N+]1=C(C(CC(C)C)=NC=C1CC(C)C)O
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Synonyms
NSC 356436
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Structure Classification
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Initial Source
Aspergillus sclerotiorum
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
순도&문서
References
[1]. Reyes Castillo N, et al. Optimization of fungicidal and acaricidal metabolite production by endophytic fungus Aspergillus sp. SPH2. Bioresour Bioprocess. 2024 Mar 5;11(1):28. [Content Brief]
[2]. Morales-Sánchez V, et al. Bioactive Metabolites from the Endophytic Fungus Aspergillus sp. SPH2. J Fungi (Basel). 2021 Feb 2;7(2):109. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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