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Pathways Recommended: Protein Tyrosine Kinase/RTK
Results for "

human protein tyrosine phosphatase 1B

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

6

Natural
Products

1

Recombinant Proteins

2

Antibodies

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N1549
    Prunin
    4 Publications Verification

    Naringenin 7-0-glucoside

    		 Enterovirus Phosphatase Infection Metabolic Disease
    Prunin is a potent inhibitor of human enterovirus A71 (HEVA71). Prunin shows strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), with an IC50 of 5.5 μM .
    Prunin
  • HY-N6082
    Rhein 8-O-β-D-Glucopyranoside
    1 Publications Verification

    		 Apoptosis Bcl-2 Family Caspase TGF-beta/Smad Bacterial Infection Metabolic Disease Inflammation/Immunology
    Rhein 8-O-β-D-Glucopyranoside is an orally active glycoside found in Rhubarb. Rhein 8-O-β-D-Glucopyranoside attenuates high glucose-induced apoptosis, recovers altered lincRNA ANRIL and let-7a expression, reverses high glucose-altered Bcl-2 and cleaved caspase-3 protein expression, and inhibits TGF-β1/Smad signaling. Rhein 8-O-β-D-Glucopyranoside accelerates Sennoside A (HY-N0365) metabolism, stimulates sennoside A purgative activity. Rhein 8-O-β-D-Glucopyranoside inhibits bacterial biofilm formation, suppresses its virulence gene expression, and exerts antibacterial activity. Rhein 8-O-β-D-Glucopyranoside can be used for the research of diabetic nephropathy, constipation, and infection .
    Rhein 8-O-β-D-Glucopyranoside
  • HY-N2451
    Aloe-emodin-8-O-β-D-glucopyranoside
    1 Publications Verification

    		 Phosphatase Metabolic Disease Endocrinology
    Aloe-emodin-8-O-β-D-glucopyranoside, a compound isolated from Saussrurea lappa, is a moderate inhibitor of human protein tyrosine phosphatase 1B (hPTP1B) with an IC50 of 26.6 μM .
    Aloe-emodin-8-O-β-D-glucopyranoside
  • HY-141800
    MurA-IN-1
    1 Publications Verification

    		 Phosphatase Others
    MurA-IN-1 (compound 1a) is a PTPRR inhibitor, with IC50 values of 0.23 μM, 0.8 μM, 0.75 μM and 0.09 μM for PTP1B, PTPN5, PTPN7 and PTPRR, respectively . (A family of human MAPK-specific protein tyrosine phosphatases)
    MurA-IN-1
  • HY-117085
    Lobaric acid

    		Phosphatase TMV Lipoxygenase Cancer
    Lobaric acid is a depsipeptide metabolite isolated from Stereocaulon lichen with antioxidant, antiproliferative, antiviral and enzyme inhibitory activities. Lobaric acid scavenges superoxide free radicals (IC50=97.9 μM) and inhibits cancer cell proliferation (EC50 of 15.2-63.9 μg/mL against leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic and lung cancer cell lines). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50=0.87 μM for human recombinant enzyme) and 12(S)-HETE produced by 12(S)-lipoxygenase (IC50=28.5 μM). Lobaric acid (250 μM) also reduced pathological changes in tobacco leaves infected with tobacco mosaic virus (TMV).
    Lobaric acid
  • HY-N8200
    Cassiaside B2

    		Phosphatase Monoamine Oxidase 5-HT Receptor Inflammation/Immunology
    Cassiaside B2 is a protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A) inhibitor. Cassiaside B2 possesses antiallergic and is a 5-HT2C receptor agonist . ..
    Cassiaside B2
  • HY-N2451R
    Aloe-emodin-8-O-β-D-glucopyranoside (Standard)

    		Reference Standards Phosphatase Metabolic Disease Endocrinology
    Aloe-emodin-8-O-β-D-glucopyranoside (Standard) is the analytical standard of Aloe-emodin-8-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Aloe-emodin-8-O-β-D-glucopyranoside, a compound isolated from Saussrurea lappa, is a moderate inhibitor of human protein tyrosine phosphatase 1B (hPTP1B) with an IC50 of 26.6 μM .
    Aloe-emodin-8-O-β-D-glucopyranoside (Standard)
  • HY-N17424
    Mulberrofuran D

    		Phosphatase Inflammation/Immunology
    Mulberrofuran D is a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with an IC50 of 11.61 μM and a Ki of 4.79 μM against human PTP1B. Mulberrofuran D can be used in research related to type 2 diabetes .
    Mulberrofuran D
  • HY-182463
    Moreollic acid

    		Phosphatase Metabolic Disease Inflammation/Immunology Cancer
    Moreollic acid is a PTP1B inhibitor, with an IC50 of 4.44 μM and a Ki of 1.75 μM against human targets. Moreollic acid blocks cell cycle progression from the G1 to S phase and inhibits tumor cell proliferation. Moreollic acid can be used in research related to type 2 diabetes, obesity, colon cancer and other cancers .
    Moreollic acid

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