2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. Moreollic acid

Moreollic acid is a PTP1B inhibitor, with an IC50 of 4.44 μM and a Ki of 1.75 μM against human targets. Moreollic acid blocks cell cycle progression from the G1 to S phase and inhibits tumor cell proliferation. Moreollic acid can be used in research related to type 2 diabetes, obesity, colon cancer and other cancers.

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Moreollic acid

Moreollic acid Chemical Structure

CAS No. : 173792-68-2

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Moreollic acid Related Antibodies

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Description

Moreollic acid is a PTP1B inhibitor, with an IC50 of 4.44 μM and a Ki of 1.75 μM against human targets. Moreollic acid blocks cell cycle progression from the G1 to S phase and inhibits tumor cell proliferation. Moreollic acid can be used in research related to type 2 diabetes, obesity, colon cancer and other cancers[1][2].

In Vitro

Moreollic acid (Compound 2) (5 μM; 48 h) potently inhibits the viability of HCT116 human colon cancer cells with an inhibition rate of 83.86%, whereas it exhibits only weak or no inhibitory effect on the viability of A549, MDA-MB-231 and KYSE30 cancer cells[2].
Moreollic acid (48 h) inhibits the viability of human colon cancer cells HCT116, DLD1 and SW620, with IC50 values of 1.71 μM, 1.44 μM and 1.49 μM, respectively; in contrast, it shows a higher IC50 value of 3.16 μM against normal NCM460 colonic epithelial cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Moreollic acid Related Antibodies

Cell Viability Assay[2]

Cell Line: A549, MDA-MB-231, KYSE30, HCT116
Concentration: 5 μM
Incubation Time: 48 h
Result: Inhibited HCT116 cell viability by 83.86%.
Showed minimal inhibition of A549 cell viability by 18.38%.
Showed minimal inhibition of MDA-MB-231 cell viability by -4.9%.
Showed minimal inhibition of KYSE30 cell viability by 20.76%.
Molecular Weight

592.68

Formula

C34H40O9
CAS No.
SMILES

OC(/C(C)=C\C[C@@]12[C@@]34[C@@](C(C5=C(O)C(C=CC(C)(O6)C)=C6C(C/C=C(C)\C)=C5O4)=O)([H])[C@H]([C@@](C[C@@]3([H])C(C)(O2)C)([H])C1=O)OC)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Moreollic acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Moreollic acid173792-68-2PhosphataseKYSE30Protein tyrosine phosphatase 1BA549PTP1BMDA-MB-231cancertype 2 diabetesHCT116 human colon cancer cellcolon cancerobesityInhibitorinhibitorinhibit

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