173792-68-2
173792-68-2
Chemical Structure
Moreollic acid
- CAS No.: 173792-68-2
- Formula:C34H40O9
- Molecular Weight:592.68
InChIKey: YWPUDSYPVZVGNW-RUEIIJHESA-N
SMILES: OC(/C(C)=C\C[C@@]12[C@@]34[C@@](C(C5=C(O)C(C=CC(C)(O6)C)=C6C(C/C=C(C)\C)=C5O4)=O)([H])[C@H]([C@@](C[C@@]3([H])C(C)(O2)C)([H])C1=O)OC)=O
Biological Activity: Moreollic acid is a PTP1B inhibitor, with an IC50 of 4.44 μM and a Ki of 1.75 μM against human targets. Moreollic acid blocks cell cycle progression from the G1 to S phase and inhibits tumor cell proliferation. Moreollic acid can be used in research related to type 2 diabetes, obesity, colon cancer and other cancers[1][2].
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Moreollic acid | Moreollic acid is a PTP1B inhibitor, with an IC50 of 4.44 μM and a Ki of 1.75 μM against human targets. Moreollic acid blocks cell cycle progression from the G1 to S phase and inhibits tumor cell proliferation. Moreollic acid can be used in research related to type 2 diabetes, obesity, colon cancer and other cancers. | |||||||||||||||||||||
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References
- [1]. Tan XF, et al. Competitive protein tyrosine phosphatase 1B (PTP1B) inhibitors, prenylated caged xanthones from Garcinia hanburyi and their inhibitory mechanism. Bioorg Med Chem. 2017 Apr 15;25(8):2498-2506. [Content Brief]
- [2]. Cheng LZ, et al. Structural Optimization and Improving Antitumor Potential of Moreollic Acid from Gamboge. Molecules. 2022;27(2):482. Published 2022 Jan 13. [Content Brief]
