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lipid+soluble

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (1) Biochemical Assay Reagents (2) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (1) Drug Derivative (4) Drug Intermediate (1) Drug Isomer (1) Drug Metabolite (1) Endogenous Metabolite (3) Fluorescent Dye (3) Insulin Receptor (1) Leukotriene Receptor (1) Nucleoside Antimetabolite/Analog (1) Phosphoramidites (1) PKG (1) Prostaglandin Receptor (2) Reference Standards (2) Tyrosinase (2) UGT (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Endocrinology (2) Infection (1) Inflammation/Immunology (1) Metabolic Disease (8) Neurological Disease (1)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Phosphoramidites (1) Guanine (1)

Inhibitors & Agonists

Fluorescent Dyes

Natural
Products

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113068

(rel)-β-Tocopherol	Tyrosinase	Metabolic Disease
(rel)-β-Tocopherol is a relative configuration of β-Tocopherol. β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity .

HY-W750676

(rac./meso)-Astaxanthin AstaREAL; AstaXin; BioAstin	Endogenous Metabolite	Metabolic Disease
rac-Astaxanthin is a carotenoid pigment found primarily in marine animals including shrimp and salmon. It is a potent lipid-soluble antioxidant.

HY-121660

Hexyl nicotinate	Drug Derivative	Cardiovascular Disease
Hexyl nicotinate is a lipid-soluble nicotinic acid ester and cutaneous vasodilator. Hexyl nicotinate induces localized cutaneous vasodilation and increases blood flow. Hexyl nicotinate can be used for the research of Raynaud's phenomenon .

HY-W750676R

(rac./meso)-Astaxanthin (Standard) AstaREAL (Standard); AstaXin (Standard); BioAstin (Standard)	Endogenous Metabolite Reference Standards	Metabolic Disease
(rac./meso)-Astaxanthin (Standard) is the analytical standard of (rac./meso)-Astaxanthin. This product is intended for research and analytical applications. rac-Astaxanthin is a carotenoid pigment found primarily in marine animals including shrimp and salmon. It is a potent lipid-soluble antioxidant.

HY-176513

Cy-OH-LP	Fluorescent Dye	Others
Cy-OH-LP is a turn-on fluorescent and photoacoustic probe that can detect lipid-associated hydroxyl radicals. Cy-OH-LP can be oxidized to Cy7 in the presence of hydroxyl radicals, which displays weak fluorescent and photoacoustic signals in water-soluble environments and strong fluorescent and photoacoustic signals in lipid-rich environments due to its lipid solubility. Cy-OH-LP can be used for in vivo photoacoustic imaging of hydroxyl radicals .

HY-164581

DMTr-2'-O-C22-rG(ibu)-3'-CE-Phosphoramidite	Phosphoramidites DNA/RNA Synthesis	Others
DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite is an RNA phosphoramidite monomer for oligonucleotide synthesis. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite enables site-specific introduction of 2'-O-C22 lipophilic modification at guanosine positions to construct double-stranded RNA (dsRNA) molecules with extrahepatic delivery capability. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite supports target gene silencing in skeletal muscle, cardiac muscle and adipose tissue by enhancing the lipid solubility and tissue uptake efficiency of dsRNA. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite can be used for the construction and mechanism research of nucleic acid silencing molecules .

HY-D0421

C.I. Solvent yellow 18	Fluorescent Dye	Others
C.I. Solvent yellow 18 is a lipid-soluble fluorescent azo dye, which is widely used in industries such as textiles, medicine, food, cosmetics, plastics, paints, inks, photography and papermaking .

HY-160254

1954U89	Dihydrofolate reductase (DHFR)	Cancer
1954U89 is a potent, lipid-soluble and orally active inhibitor of dihydrofolate reductase (DHFR). 1954U89 exhibits anticancer activity .

HY-D1074

DiOC3(3) 3,3'-Dipropyloxacarbocyanine iodide	Fluorescent Dye	Others
DiOC3(3) (3,3'-Dipropyloxacarbocyanine iodide) is a green fluorescent lipophilic dye with cell membrane permeability. DiOC3(3) can be used to stain cell membranes and other lipid-soluble biological structures .

HY-113068R

(rel)-β-Tocopherol (Standard)	Reference Standards Tyrosinase	Metabolic Disease
(rel)-β-Tocopherol (Standard) is the analytical standard of (rel)-β-Tocopherol. This product is intended for research and analytical applications. (rel)-β-Tocopherol is a relative configuration of β-Tocopherol.(±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-137373

Rp-8-pCPT-cGMPS	PKG	Others
Rp-8-pCPT-cGMPS is a competitive inhibitor of cGMP-dependent protein kinase (PKG) (K_i=0.5 μM). Rp-8-pCPT-cGMPS has high lipid solubility and can more easily penetrate the cell membrane and reach sufficient concentration inside the cell to inhibit cGMP-dependent protein kinase. Rp-8-pCPT-cGMPS can be used to study the activity and function of cGMP-dependent protein kinase in platelets .

HY-401721

5-CNAC	Biochemical Assay Reagents	Others
5-CNAC is an orally active enhancer of absorption, with no pharmacological activity on its own. 5-CNAC can significantly enhance the absorption efficiency of the drug (such as Salmon calcitonin (HY-P0090)) when administered together with it in the gastrointestinal tract. 5-CNAC binds reversibly and non-covalently to peptide drugs, protecting them from degradation by gastrointestinal enzymes, increasing their lipid solubility, promoting passive transcellular absorption, and not damaging the integrity of the intestinal epithelium. 5-CNAC can be used in the research of adjuvants for orally administered peptide agents .

HY-141635

cis-11,14-Eicosadienoic acid methyl ester	Endogenous Metabolite	Metabolic Disease
cis-11,14-Eicosadienoic acid methyl ester is a more lipid soluble form of the ω-6 C20-2 fatty acid 11(Z),14(Z)-eicosadienoic acid, a naturally occurring PUFA. 11(Z),14(Z)-Eicosadienoic acid competitively inhibits inosine 5’-monophosphate dehydrogenase (Ki=3.1 μM) and inhibits the binding of LTB4 to its receptor on neutrophils (Ki=3.0 μM). Also, serum levels of eicosadienoic acids negatively correlate with degree of sleep disturbance.3 Eicosadienoic acids are converted by desaturases, in vivo, to eicosatrienoic acids, which are potent vasodilators.

HY-100571A

(+)-5-trans Cloprostenol isopropyl ester	Drug Isomer	Metabolic Disease
(+)-5-trans Cloprostenol isopropyl ester is a more lipid-soluble form of (+)-5-trans cloprostenol (HY-120955), which is a synthetic derivative of prostaglandin F2α .

HY-17659

Decylplastoquinone	Drug Derivative	Others
Decylplastoquinone is lipid-soluble derivative of plastoquinone (HY-N11882). Plastoquinone (PQ-9), a potent electron carrier, is an essential component of photosynthesis. Plastoquinone is also a redox sensor that regulates state transitions and gene expression .

HY-137412

PGF2α 1,15-lactone Prostaglandin F2α 1,15-lactone	Drug Derivative	Endocrinology
PGF2α 1,15-lactone (Prostaglandin F2α 1,15-lactone) is a lipid-soluble internal ester of PGF2α. PGF2α 1,15-lactone decreases menstrual cycle lengths in non-pregnant rhesus monkeys. PGF2α 1,15-lactone terminates early pregnancy in the monkey .

HY-116844

Glymidine Glidiazine	Drug Derivative Insulin Receptor	Metabolic Disease
Glymidine (Glidiazine) is a hypoglycaemic agent. Glymidine is a lipid soluble sulphapyrimidine derivative. Glymidine appears to stimulate insulin release from pancreas. Glymidine is a possible alternative to the sulphonylureas and biguanides for the research of diabetes mellitus .

HY-118648

Prostaglandin F2α methyl ester PGF2α methyl ester; Dinoprost methyl	Prostaglandin Receptor	Others
Prostaglandin F2α methyl ester (PGF2α methyl ester; Dinoprost methyl) is a PGF_2α analog with more lipid solubility. Prostaglandin F2α methyl ester exhibits efficacy in maintaining the ocular hypotensive .

HY-124200

AL 8810 isopropyl ester	Prostaglandin Receptor	Endocrinology
AL 8810 (Item No. 16735) is an 11β-fluoro analog of prostaglandin F2α which acts as a potent and selective antagonist at the FP receptor. AL 8810 isopropyl ester is a lipid soluble, esterified prodrug form of AL 8810 analogous to the commonly used therapeutic intraocular prostaglandin compounds such as Latanoprost (HY-B0577) and Travoprost (HY-B0584).

HY-134123

Lipoxin B4 methyl ester LXB4 methyl ester	Drug Intermediate Leukotriene Receptor	Metabolic Disease
Lipoxin B4 (LXB4) methyl ester is a lipid soluble prodrug form of the transcellular metabolite LXB4. LXB4 is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 (LTB4; Item No. 20110) and inhibits LTB4-induced adhesion of PMNs with an IC₅₀ value of 0.3 nM.

HY-178962

Antitumor agent-207	Drug Metabolite	Cancer
Antitumor agent-207 (compound 10K) is a Pt(IV)-NO prodrug with high lipid solubility, good stability, and excellent tumor targeted release ability. Antitumor agent-207 has significant anti proliferative activity in various cells such as TE-1 (IC₅₀ = 1.79 μM), TE-10 (IC₅₀ = 1.95 μM), KYSE-30 IC₅₀ = 5.99 μM), KYSE-520 (IC₅₀ = 5.53 μM) cells. Antitumor agent-207 can significantly enhance intracellular Pt accumulation and DNA platformization levels, and effectively release NO. Antitumor agent-207 can be used for research on cancers such as esophageal cancer .

HY-W1121876

1-Terpineol	Bacterial	Infection Neurological Disease Inflammation/Immunology
1-Terpineol is a lipid-soluble monoterpenoid alcohol compound found in Myristica fragrans Houtt.. 1-Terpineol exhibits antibacterial, antioxidant and anti-inflammatory activities .

HY-W1119946

(3R,5S)-5-O-DMT-3-pyrrolidinol-benzyl laurate	Nucleoside Antimetabolite/Analog	Others
(3R,5S)-5-O-DMT-3-pyrrolidinol-benzyl laurate is a laurate derivative with a dimethoxytrityl (DMT) protecting group and a 3-pyrrolidinol structure. (3R,5S)-5-O-DMT-3-pyrrolidinol-benzyl laurate can be used for oligonucleotide modification or as a lipid-soluble delivery vehicle.

HY-156957

5-CNAC disodium	Biochemical Assay Reagents	Others
5-CNAC disodium is an orally active enhancer of absorption, with no pharmacological activity on its own. 5-CNAC disodium can significantly enhance the absorption efficiency of the drug (such as Salmon calcitonin (HY-P0090)) when administered together with it in the gastrointestinal tract. 5-CNAC disodium binds reversibly and non-covalently to peptide drugs, protecting them from degradation by gastrointestinal enzymes, increasing their lipid solubility, promoting passive transcellular absorption, and not damaging the integrity of the intestinal epithelium. 5-CNAC disodium can be used in the research of adjuvants for orally administered peptide agents .

HY-W006081

3-Methyl-2-nitrophenol	UGT	Others
3-Methyl-2-nitrophenol is a UDP-glucuronyltransferase (EC 2.4.1.17) acceptor substrate that can be confirmed to undergo glucuronidation catalyzed by the enzyme to form a glucuronide conjugate. 3-Methyl-2-nitrophenol functions as a substrate for conjugation, with glucuronidation forming a glucuronide conjugate that eliminates the parent compound’s characteristic yellow color. 3-Methyl-2-nitrophenol has higher lipid solubility that contributes to high glucuronidation conversion rate, and exhibits lower absorbance at 340 nm to act as a less interfering substrate for the NADH-NAD ⁺-linked UDP-glucuronyltransferase assay .

Cat. No.	Product Name	Type

HY-D0421

C.I. Solvent yellow 18	Fluorescent Dyes
C.I. Solvent yellow 18 is a lipid-soluble fluorescent azo dye, which is widely used in industries such as textiles, medicine, food, cosmetics, plastics, paints, inks, photography and papermaking .

HY-D1074

DiOC3(3) 3,3'-Dipropyloxacarbocyanine iodide	Fluorescent Dyes
DiOC3(3) (3,3'-Dipropyloxacarbocyanine iodide) is a green fluorescent lipophilic dye with cell membrane permeability. DiOC3(3) can be used to stain cell membranes and other lipid-soluble biological structures .

(rel)-β-Tocopherol	Structural Classification Monophenols Classification of Application Fields Agrostidoideae Phenols Metabolic Disease Plants Disease Research Fields Triticum aestivum L. Source Classification	Tyrosinase
(rel)-β-Tocopherol is a relative configuration of β-Tocopherol. β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity .

(rel)-β-Tocopherol (Standard)	Structural Classification Monophenols Microorganisms Agrostidoideae Phenols Plants Triticum aestivum L. Source Classification	Reference Standards Tyrosinase
(rel)-β-Tocopherol (Standard) is the analytical standard of (rel)-β-Tocopherol. This product is intended for research and analytical applications. (rel)-β-Tocopherol is a relative configuration of β-Tocopherol.(±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

1-Terpineol	Structural Classification Other Monoterpenes Terpenoids Labiatae Plants Viguiera eriophora Greenm. Source Classification	Bacterial
1-Terpineol is a lipid-soluble monoterpenoid alcohol compound found in Myristica fragrans Houtt.. 1-Terpineol exhibits antibacterial, antioxidant and anti-inflammatory activities .

Cat. No.	Product Name		Classification

HY-178962

Antitumor agent-207		Alkynes
Antitumor agent-207 (compound 10K) is a Pt(IV)-NO prodrug with high lipid solubility, good stability, and excellent tumor targeted release ability. Antitumor agent-207 has significant anti proliferative activity in various cells such as TE-1 (IC₅₀ = 1.79 μM), TE-10 (IC₅₀ = 1.95 μM), KYSE-30 IC₅₀ = 5.99 μM), KYSE-520 (IC₅₀ = 5.53 μM) cells. Antitumor agent-207 can significantly enhance intracellular Pt accumulation and DNA platformization levels, and effectively release NO. Antitumor agent-207 can be used for research on cancers such as esophageal cancer .

Cat. No.	Product Name		Classification

HY-164581

DMTr-2'-O-C22-rG(ibu)-3'-CE-Phosphoramidite		Phosphoramidites Guanine
DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite is an RNA phosphoramidite monomer for oligonucleotide synthesis. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite enables site-specific introduction of 2'-O-C22 lipophilic modification at guanosine positions to construct double-stranded RNA (dsRNA) molecules with extrahepatic delivery capability. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite supports target gene silencing in skeletal muscle, cardiac muscle and adipose tissue by enhancing the lipid solubility and tissue uptake efficiency of dsRNA. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite can be used for the construction and mechanism research of nucleic acid silencing molecules .

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lipid+soluble

Inhibitors & Agonists

Fluorescent Dyes

NaturalProducts

Click Chemistry

Oligonucleotides

Natural
Products