Hexyl nicotinate
Based on 1 Customer Validation
Hexyl nicotinate is a lipid-soluble nicotinic acid ester and cutaneous vasodilator. Hexyl nicotinate induces localized cutaneous vasodilation and increases blood flow. Hexyl nicotinate can be used for the research of Raynaud's phenomenon.
For research use only. We do not sell to patients.
- Purity: 98.96%
- CAS No.: 23597-82-2
- Formula: C12H17NO2
- Molecular Weight:207.27
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Hexyl nicotinate induces significant increases in blood flow and erythema on the forearm, while the response rate decreases in the more distal hands and fingers[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 23597-82-2
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Appearance Liquid (Density: 1.02 g/cm3)
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Molecular Weight 207.27
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Formula C12H17NO2
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Color Colorless to light yellow
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SMILES
O=C(OCCCCCC)C1=CC=CN=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (482.46 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (12.06 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Dowd PM, et al. Hexyl-nicotinate-induced vasodilation in normal human skin. Dermatologica. 1987;174(5):239-243. [Content Brief]
[2]. Bunker CB, et al. The effects of topically applied hexyl nicotinate lotion on the cutaneous blood flow in patients with Raynaud's phenomenon. Br J Dermatol. 1988;119(6):771-776. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.8246 mL | 24.1231 mL | 48.2462 mL | 120.6156 mL |
| 5 mM | 0.9649 mL | 4.8246 mL | 9.6492 mL | 24.1231 mL | |
| 10 mM | 0.4825 mL | 2.4123 mL | 4.8246 mL | 12.0616 mL | |
| 15 mM | 0.3216 mL | 1.6082 mL | 3.2164 mL | 8.0410 mL | |
| 20 mM | 0.2412 mL | 1.2062 mL | 2.4123 mL | 6.0308 mL | |
| 25 mM | 0.1930 mL | 0.9649 mL | 1.9298 mL | 4.8246 mL | |
| 30 mM | 0.1608 mL | 0.8041 mL | 1.6082 mL | 4.0205 mL | |
| 40 mM | 0.1206 mL | 0.6031 mL | 1.2062 mL | 3.0154 mL | |
| 50 mM | 0.0965 mL | 0.4825 mL | 0.9649 mL | 2.4123 mL | |
| 60 mM | 0.0804 mL | 0.4021 mL | 0.8041 mL | 2.0103 mL | |
| 80 mM | 0.0603 mL | 0.3015 mL | 0.6031 mL | 1.5077 mL | |
| 100 mM | 0.0482 mL | 0.2412 mL | 0.4825 mL | 1.2062 mL |
Hexyl nicotinate Related Classifications
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