2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. Antitumor agent-207

Antitumor agent-207 (compound 10K) is a Pt(IV)-NO prodrug with high lipid solubility, good stability, and excellent tumor targeted release ability. Antitumor agent-207 has significant anti proliferative activity in various cells such as TE-1 (IC50 = 1.79 μM), TE-10 (IC50 = 1.95 μM), KYSE-30 IC50 = 5.99 μM), KYSE-520 (IC50 = 5.53 μM) cells. Antitumor agent-207 can significantly enhance intracellular Pt accumulation and DNA platformization levels, and effectively release NO. Antitumor agent-207 can be used for research on cancers such as esophageal cancer.

For research use only. We do not sell to patients.

Antitumor agent-207

Antitumor agent-207 Chemical Structure

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Antitumor agent-207 Related Antibodies

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Description

Antitumor agent-207 (compound 10K) is a Pt(IV)-NO prodrug with high lipid solubility, good stability, and excellent tumor targeted release ability. Antitumor agent-207 has significant anti proliferative activity in various cells such as TE-1 (IC50 = 1.79 μM), TE-10 (IC50 = 1.95 μM), KYSE-30 IC50 = 5.99 μM), KYSE-520 (IC50 = 5.53 μM) cells. Antitumor agent-207 can significantly enhance intracellular Pt accumulation and DNA platformization levels, and effectively release NO. Antitumor agent-207 can be used for research on cancers such as esophageal cancer[1].

Molecular Weight

877.56

Formula

C26H32Cl2F3N7O7Pt
SMILES

[O-]/[N+](N1CCN(C(CCC(O[Pt]([NH3])([NH3])(Cl)(Cl)OC(NCC2=CC=C(C3=CC=C(C(F)(F)F)C=C3)C=C2)=O)=O)=O)CC1)=N\OCC#C
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Antitumor agent-207 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-207Antitumor agent207Antitumor agent 207Drug MetabolitePt(IV)-NOprodrugTE-1TE-10KYSE-30KYSE-520cancerInhibitorinhibitorinhibit

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