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  4. 5-CNAC

5-CNAC is an orally active enhancer of absorption, with no pharmacological activity on its own. 5-CNAC can significantly enhance the absorption efficiency of the drug (such as Salmon calcitonin (HY-P0090)) when administered together with it in the gastrointestinal tract. 5-CNAC binds reversibly and non-covalently to peptide drugs, protecting them from degradation by gastrointestinal enzymes, increasing their lipid solubility, promoting passive transcellular absorption, and not damaging the integrity of the intestinal epithelium. 5-CNAC can be used in the research of adjuvants for orally administered peptide agents.

For research use only. We do not sell to patients.

5-CNAC

5-CNAC Chemical Structure

CAS No. : 204852-67-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Other Forms of 5-CNAC:

5-CNAC Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

5-CNAC is an orally active enhancer of absorption, with no pharmacological activity on its own. 5-CNAC can significantly enhance the absorption efficiency of the drug (such as Salmon calcitonin (HY-P0090)) when administered together with it in the gastrointestinal tract. 5-CNAC binds reversibly and non-covalently to peptide drugs, protecting them from degradation by gastrointestinal enzymes, increasing their lipid solubility, promoting passive transcellular absorption, and not damaging the integrity of the intestinal epithelium. 5-CNAC can be used in the research of adjuvants for orally administered peptide agents[1][2].

In Vitro

5-CNAC (0.01-500 μg/mL; 30 min) exhibits high plasma protein binding (>99%) in human plasma and serum in vitro at concentrations up to 100 μg/mL, with binding site saturation observed at 500 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5-CNAC Related Antibodies
Molecular Weight

313.78

Formula

C15H20ClNO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCCCCCCNC(C1=CC(Cl)=CC=C1O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (318.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1869 mL 15.9347 mL 31.8695 mL
5 mM 0.6374 mL 3.1869 mL 6.3739 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1869 mL 15.9347 mL 31.8695 mL 79.6737 mL
5 mM 0.6374 mL 3.1869 mL 6.3739 mL 15.9347 mL
10 mM 0.3187 mL 1.5935 mL 3.1869 mL 7.9674 mL
15 mM 0.2125 mL 1.0623 mL 2.1246 mL 5.3116 mL
20 mM 0.1593 mL 0.7967 mL 1.5935 mL 3.9837 mL
25 mM 0.1275 mL 0.6374 mL 1.2748 mL 3.1869 mL
30 mM 0.1062 mL 0.5312 mL 1.0623 mL 2.6558 mL
40 mM 0.0797 mL 0.3984 mL 0.7967 mL 1.9918 mL
50 mM 0.0637 mL 0.3187 mL 0.6374 mL 1.5935 mL
60 mM 0.0531 mL 0.2656 mL 0.5312 mL 1.3279 mL
80 mM 0.0398 mL 0.1992 mL 0.3984 mL 0.9959 mL
100 mM 0.0319 mL 0.1593 mL 0.3187 mL 0.7967 mL
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5-CNAC Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-CNAC204852-67-5Biochemical Assay Reagents14C-radiolabelADMEOral absorption enhancerSalmon calcitoninPostmenopausal womenInhibitorinhibitorinhibit

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