2. Metabolic Enzyme/Protease
  3. Dihydrofolate reductase (DHFR)
  4. 1954U89

1954U89 is a potent, lipid-soluble and orally active inhibitor of dihydrofolate reductase (DHFR). 1954U89 exhibits anticancer activity.

For research use only. We do not sell to patients.

1954U89

1954U89 Chemical Structure

CAS No. : 150057-49-1

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1954U89 Related Antibodies

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Description

1954U89 is a potent, lipid-soluble and orally active inhibitor of dihydrofolate reductase (DHFR). 1954U89 exhibits anticancer activity[1][2].

Cellular Effect
Cell Line Type Value Description References
143B IC50
0.8 nM
Compound: 5o
Cytotoxic Activity was evaluated against 143B (TK-) tumor cells
Cytotoxic Activity was evaluated against 143B (TK-) tumor cells
[PMID: 8632413]
A549 IC50
0.4 nM
Compound: 5o
Cytotoxic activity evaluated against A549 tumor cells
Cytotoxic activity evaluated against A549 tumor cells
[PMID: 8632413]
Daoy IC50
2.3 nM
Compound: 5o
Cytotoxic activity was evaluated against Daoy tumor cells
Cytotoxic activity was evaluated against Daoy tumor cells
[PMID: 8632413]
HCT-8 IC50
0.74 nM
Compound: 5o
Activity was evaluated against HCT-8 tumor cells
Activity was evaluated against HCT-8 tumor cells
[PMID: 8632413]
NCI-H460 IC50
0.5 nM
Compound: 5o
Cytotoxic Activity was evaluated against H460 tumor cells
Cytotoxic Activity was evaluated against H460 tumor cells
[PMID: 8632413]
P388 IC50
0.12 nM
Compound: 5o
Cytotoxic activity was evaluated against P388D1 tumor cells
Cytotoxic activity was evaluated against P388D1 tumor cells
[PMID: 8632413]
U-373MG ATCC IC50
2.3 nM
Compound: 5o
Cytotoxic activity was evaluated against U373MG tumor cells
Cytotoxic activity was evaluated against U373MG tumor cells
[PMID: 8632413]
U-87MG ATCC IC50
2.1 nM
Compound: 5o
Cytotoxic activity was evaluated against U87MG tumor cells
Cytotoxic activity was evaluated against U87MG tumor cells
[PMID: 8632413]
Vero IC50
1 nM
Compound: 5o
Cytotoxic Activity was evaluated against Vero tumor cells
Cytotoxic Activity was evaluated against Vero tumor cells
[PMID: 8632413]
Molecular Weight

283.37

Formula

C16H21N5
CAS No.
SMILES

CC(N1C(CC)CC)=CC2=C1C=CC3=NC(N)=NC(N)=C23
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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1954U89 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1954U89150057-49-1Dihydrofolate reductase (DHFR)Inhibitorinhibitorinhibit

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