2. Others Cell Cycle/DNA Damage
  3. Phosphoramidites DNA/RNA Synthesis
  4. DMTr-2'-O-C22-rG(ibu)-3'-CE-Phosphoramidite

DMTr-2'-O-C22-rG(ibu)-3'-CE-Phosphoramidite 

Cat. No.: HY-164581 Purity: 98.0%
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DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite is an RNA phosphoramidite monomer for oligonucleotide synthesis. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite enables site-specific introduction of 2'-O-C22 lipophilic modification at guanosine positions to construct double-stranded RNA (dsRNA) molecules with extrahepatic delivery capability. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite supports target gene silencing in skeletal muscle, cardiac muscle and adipose tissue by enhancing the lipid solubility and tissue uptake efficiency of dsRNA. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite can be used for the construction and mechanism research of nucleic acid silencing molecules.

For research use only. We do not sell to patients.

DMTr-2'-O-C22-rG(ibu)-3'-CE-Phosphoramidite

DMTr-2'-O-C22-rG(ibu)-3'-CE-Phosphoramidite Chemical Structure

CAS No. : 2923115-75-5

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DMTr-2'-O-C22-rG(ibu)-3'-CE-Phosphoramidite Related Antibodies

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Description

DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite is an RNA phosphoramidite monomer for oligonucleotide synthesis. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite enables site-specific introduction of 2'-O-C22 lipophilic modification at guanosine positions to construct double-stranded RNA (dsRNA) molecules with extrahepatic delivery capability. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite supports target gene silencing in skeletal muscle, cardiac muscle and adipose tissue by enhancing the lipid solubility and tissue uptake efficiency of dsRNA. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite can be used for the construction and mechanism research of nucleic acid silencing molecules[1].

In Vitro

DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite (Compound 106) is synthesized via phosphoramidite coupling reaction with 2-cyanoethyl N,N-diisopropylchlorophosphoramidite, monitored by TLC (Rf = 0.6 in 50% ethyl acetate/hexane), purified by silica gel column chromatography to obtain a white solid with 73% yield (1.76 g), and characterized by 1H NMR (600 MHz, CD3CN), 31P NMR (243 MHz, CD3CN) and LC-MS (ESI) with observed [M+H]⁺ = 1164.8[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DMTr-2'-O-C22-rG(ibu)-3'-CE-Phosphoramidite Related Antibodies
Molecular Weight

1164.50

Formula

C66H98N7O9P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC(C=C1)=CC=C1C(C2=CC=C(C=C2)OC)(C3=CC=CC=C3)OC[C@@H]4[C@@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H](OCCCCCCCCCCCCCCCCCCCCCC)[C@H](N5C(NC(NC(C(C)C)=O)=NC6=O)=C6N=C5)O4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (85.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8587 mL 4.2937 mL 8.5874 mL
5 mM 0.1717 mL 0.8587 mL 1.7175 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8587 mL 4.2937 mL 8.5874 mL 21.4684 mL
5 mM 0.1717 mL 0.8587 mL 1.7175 mL 4.2937 mL
10 mM 0.0859 mL 0.4294 mL 0.8587 mL 2.1468 mL
15 mM 0.0572 mL 0.2862 mL 0.5725 mL 1.4312 mL
20 mM 0.0429 mL 0.2147 mL 0.4294 mL 1.0734 mL
25 mM 0.0343 mL 0.1717 mL 0.3435 mL 0.8587 mL
30 mM 0.0286 mL 0.1431 mL 0.2862 mL 0.7156 mL
40 mM 0.0215 mL 0.1073 mL 0.2147 mL 0.5367 mL
50 mM 0.0172 mL 0.0859 mL 0.1717 mL 0.4294 mL
60 mM 0.0143 mL 0.0716 mL 0.1431 mL 0.3578 mL
80 mM 0.0107 mL 0.0537 mL 0.1073 mL 0.2684 mL
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DMTr-2'-O-C22-rG(ibu)-3'-CE-Phosphoramidite Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DMTr-2'-O-C22-rG(ibu)-3'-CE-Phosphoramidite2923115-75-5PhosphoramiditesDNA/RNA Synthesisisobutyrylguanosine2'-O-C22 hydrocarbon chaincyanoethyl phosphoramidite protective groupsdsRNAextra-hepatic deliverydimethoxytritylInhibitorinhibitorinhibit

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