DMTr-2'-O-C22-rG(ibu)-3'-CE-Phosphoramidite
Based on 1 Customer Validation
DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite is an RNA phosphoramidite monomer for oligonucleotide synthesis. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite enables site-specific introduction of 2'-O-C22 lipophilic modification at guanosine positions to construct double-stranded RNA (dsRNA) molecules with extrahepatic delivery capability. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite supports target gene silencing in skeletal muscle, cardiac muscle and adipose tissue by enhancing the lipid solubility and tissue uptake efficiency of dsRNA. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite can be used for the construction and mechanism research of nucleic acid silencing molecules.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 2923115-75-5
- Formula: C66H98N7O9P
- Molecular Weight:1164.50
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
Description
In Vitro
DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite (Compound 106) is synthesized via phosphoramidite coupling reaction with 2-cyanoethyl N,N-diisopropylchlorophosphoramidite, monitored by TLC (Rf = 0.6 in 50% ethyl acetate/hexane), purified by silica gel column chromatography to obtain a white solid with 73% yield (1.76 g), and characterized by 1H NMR (600 MHz, CD3CN), 31P NMR (243 MHz, CD3CN) and LC-MS (ESI) with observed [M+H]⁺ = 1164.8[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2923115-75-5
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Appearance Solid
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Molecular Weight 1164.50
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Formula C66H98N7O9P
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Color White to off-white
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SMILES
COC(C=C1)=CC=C1C(C2=CC=C(C=C2)OC)(C3=CC=CC=C3)OC[C@@H]4[C@@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H](OCCCCCCCCCCCCCCCCCCCCCC)[C@H](N5C(NC(NC(C(C)C)=O)=NC6=O)=C6N=C5)O4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (85.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8587 mL | 4.2937 mL | 8.5874 mL | 21.4684 mL |
| 5 mM | 0.1717 mL | 0.8587 mL | 1.7175 mL | 4.2937 mL | |
| 10 mM | 0.0859 mL | 0.4294 mL | 0.8587 mL | 2.1468 mL | |
| 15 mM | 0.0572 mL | 0.2862 mL | 0.5725 mL | 1.4312 mL | |
| 20 mM | 0.0429 mL | 0.2147 mL | 0.4294 mL | 1.0734 mL | |
| 25 mM | 0.0343 mL | 0.1717 mL | 0.3435 mL | 0.8587 mL | |
| 30 mM | 0.0286 mL | 0.1431 mL | 0.2862 mL | 0.7156 mL | |
| 40 mM | 0.0215 mL | 0.1073 mL | 0.2147 mL | 0.5367 mL | |
| 50 mM | 0.0172 mL | 0.0859 mL | 0.1717 mL | 0.4294 mL | |
| 60 mM | 0.0143 mL | 0.0716 mL | 0.1431 mL | 0.3578 mL | |
| 80 mM | 0.0107 mL | 0.0537 mL | 0.1073 mL | 0.2684 mL |
DMTr-2'-O-C22-rG(ibu)-3'-CE-Phosphoramidite Related Classifications
HY-164581 Related Classifications
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