DMTr-2'-O-C22-rG(ibu)-3'-CE-Phosphoramidite

製品番号: HY-164581 純度: 98.0%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite is an RNA phosphoramidite monomer for oligonucleotide synthesis. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite enables site-specific introduction of 2'-O-C22 lipophilic modification at guanosine positions to construct double-stranded RNA (dsRNA) molecules with extrahepatic delivery capability. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite supports target gene silencing in skeletal muscle, cardiac muscle and adipose tissue by enhancing the lipid solubility and tissue uptake efficiency of dsRNA. DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite can be used for the construction and mechanism research of nucleic acid silencing molecules.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

DMTr-2'-O-C22-rG(ibu)-3'-CE-Phosphoramidite 構造式

CAS 番号 : 2923115-75-5

容量	価格（税別）	在庫状況	数量
5 mg	$175	在庫あり	Estimated Time of Arrival: December 31
10 mg	$280	在庫あり	Estimated Time of Arrival: December 31
25 mg	$560	在庫あり	Estimated Time of Arrival: December 31
50 mg	$900	在庫あり	Estimated Time of Arrival: December 31
100 mg	$1450	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

体外実験

DMTr-2'-O-C22-rG (ibu)-3'-CE-Phosphoramidite (Compound 106) is synthesized via phosphoramidite coupling reaction with 2-cyanoethyl N,N-diisopropylchlorophosphoramidite, monitored by TLC (Rf = 0.6 in 50% ethyl acetate/hexane), purified by silica gel column chromatography to obtain a white solid with 73% yield (1.76 g), and characterized by ¹H NMR (600 MHz, CD₃CN), ³¹P NMR (243 MHz, CD₃CN) and LC-MS (ESI) with observed [M+H]⁺ = 1164.8^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1164.50

分子式

C₆₆H₉₈N₇O₉P

CAS 番号

2923115-75-5

Appearance

Solid

Color

White to off-white

SMILES

COC(C=C1)=CC=C1C(C2=CC=C(C=C2)OC)(C3=CC=CC=C3)OC[C@@H]4[C@@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H](OCCCCCCCCCCCCCCCCCCCCCC)[C@H](N5C(NC(NC(C(C)C)=O)=NC6=O)=C6N=C5)O4

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (85.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8587 mL	4.2937 mL	8.5874 mL
5 mM	0.1717 mL	0.8587 mL	1.7175 mL
10 mM	0.0859 mL	0.4294 mL	0.8587 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.0%

Select Batch:

データシート (272 KB) SDS (252 KB)

COA (249 KB) HNMR (406 KB) CNMR (324 KB) MS (72 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Jayaprakash K. NAIR, et al. Extra-hepatic delivery iRNA compositions and methods of use thereof. WO2023064530A1. WIPO (PCT). 2023-04-20.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.8587 mL	4.2937 mL	8.5874 mL	21.4684 mL
	5 mM	0.1717 mL	0.8587 mL	1.7175 mL	4.2937 mL
	10 mM	0.0859 mL	0.4294 mL	0.8587 mL	2.1468 mL
	15 mM	0.0572 mL	0.2862 mL	0.5725 mL	1.4312 mL
	20 mM	0.0429 mL	0.2147 mL	0.4294 mL	1.0734 mL
	25 mM	0.0343 mL	0.1717 mL	0.3435 mL	0.8587 mL
	30 mM	0.0286 mL	0.1431 mL	0.2862 mL	0.7156 mL
	40 mM	0.0215 mL	0.1073 mL	0.2147 mL	0.5367 mL
	50 mM	0.0172 mL	0.0859 mL	0.1717 mL	0.4294 mL
	60 mM	0.0143 mL	0.0716 mL	0.1431 mL	0.3578 mL
	80 mM	0.0107 mL	0.0537 mL	0.1073 mL	0.2684 mL