31 Results for "

nanoparticle formulations

" in MedChemExpress (MCE) Product Catalog:
Products (31)

31 Results for "nanoparticle formulations" in MCE Product Catalog:

7
7 Cited Publications
Cat. No.: HY-P99974
Synonyms: nanoparticle albumin-bound Paclitaxel; nanoparticle albumin-bound ABI-007

Research Areas:  

Cancer

Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel (HY-B0015). Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel, in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug. Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability. Nab-Paclitaxel displays less toxicity and greater antitumor activity. Nab-Paclitaxel is more readily available for tumor cell uptake in three rhabdomyosarcoma, seven neuroblastoma cell lines, and one ostersarcoma cell line Nab-Paclitaxel can be studied in cancer research for example breast cancer and solid tumors. (The product specifications below only indicate the effective content of Paditaxel, the actual albumin quality depends on the batch; the ratio of each ingredient in this product is Paditaxel: albumin -1:7~1:11) .
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Cat. No.: HY-B1620L
CAS No.: 9003-39-8
Synonyms: PVP, average Mw~40000; Polyvidone, average Mw~40000; Povidone, average Mw~40000
Polyvinylpyrrolidone, average Mw~40000 is a multifunctional synthetic polymer with an average molecular weight of 40,000 Da. Polyvinylpyrrolidone, average Mw~40000 is widely used to synthesize nanoparticles. Polyvinylpyrrolidone, average Mw~40000 is a versatile excipient for both conventional formulations and novel controlled or targeted delivery systems, serving as a binder, coating agent, suspending agent, pore-former, solubilizer, stabilizer, etc .
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Cat. No.: HY-N16040
CAS No.: 2936622-30-7
Category:  

Lipids

Target:  

Liposome

DMG-pSar25 is a double lipid-tailed polysarcosine lipid with 25 sarcosine moieties, serving as a PEG lipid substitute in lipid nanoparticle formulations for mRNA delivery. DMG-pSar25 supports mRNA delivery in lipid nanoparticle formulations .
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Cat. No.: HY-145794
CAS No.: 2090299-48-0
Purity:  ≥98.0%
ZA3-Ep10 is a zwitterionic lipid used in lipid nanoparticles formulation for in vivo RNA delivery.
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Cat. No.: HY-144012
CAS No.: 474922-84-4
Purity:  99.83%
Synonyms: 16:0 PEG2000 PE ammonium; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] ammonium
DPPE-PEG2000 ammonium (16:0 PEG5000 PE) is a polymer-lipid conjugate and LipoParticle stabilizer with a PEG chain of 5,000 g/mol molecular weight attached to its polar head, and it can be internalized by biological membranes. DPPE-PEG2000 ammonium enables LipoParticle to maintain colloidal stability after 20-fold dilution in PBS or cell culture medium, and prevents aggregate formation during lyophilization and rehydration. DPPE-PEG2000 ammonium helps enhance the non-cytotoxic property of LipoParticle formulations against human osteoblasts. DPPE-PEG2000 ammonium serves as a PEG lipid functional end group for synthesizing liposomes (LPs), is used in the design of conjugated polymer nanoparticles, and applies to research related to bone and joint infections .
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Cat. No.: HY-153235
COVID-19 Spike Protein mRNA-LNP is a lipid nanoparticle (LNP) containing mRNA encoding COVID-19 Spike Protein. COVID-19 Spike Protein undertakes the functions of virus binding with host cell receptors, thereby mediating the entry of COVID-19 virus into cells. COVID-19 Spike Protein is an important site of action for host neutralizing antibodies and a key target for vaccine design. COVID-19 Spike Protein mRNA-LNP can be used for RNA delivery, vaccine formulation and design targeting SARS-CoV-2 .
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Cat. No.: HY-144012H
CAS No.: 474922-84-4
Synonyms: 16:0 PEG5000 PE; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000] ammonium
DPPE-PEG5000 (16:0 PEG5000 PE) is a polymer-lipid conjugate and LipoParticle stabilizer with a PEG chain of 5,000 g/mol molecular weight attached to its polar head, and it can be internalized by biological membranes. DPPE-PEG5000 enables LipoParticle to maintain colloidal stability after 20-fold dilution in PBS or cell culture medium, and prevents aggregate formation during lyophilization and rehydration. DPPE-PEG5000 helps enhance the non-cytotoxic property of LipoParticle formulations against human osteoblasts. DPPE-PEG5000 serves as a PEG lipid functional end group for synthesizing liposomes (LPs), is used in the design of conjugated polymer nanoparticles, and applies to research related to bone and joint infections .
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Cat. No.: HY-137499
CAS No.: 2739805-63-9
Purity:  ≥95.0%
NT1-O12B, an endogenous chemical and a neurotransmitter-derived lipidoid (NT-lipidoid), is an effective carrier for enhanced brain delivery of several blood-brain barrier (BBB)-impermeable cargos. Doping NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) gives the LNPs the ability to cross the BBB. NT-lipidoids formulation not only facilitate cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination .
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Cat. No.: HY-160113E
Sodium phosphate buffer 0.1M, pH 8.0 is an aqueous sodium phosphate buffer with a concentration of 0.1M and a pH value of 8.0. Sodium phosphate buffer 0.1M, pH 8.0 can be used for the preparation of hydrated micellar membranes, the construction of pH-sensitive nanocarriers, and the maintenance of stable environmental conditions for pH-cleavable PEG-Hz-PE micelles. Sodium phosphate buffer 0.1M, pH 8.0 can also serve as a universal solvent, reaction medium and eluent, and is widely applied in experimental processes such as antibody thiolation, nanoparticle purification and cross-linking reactions .
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Cat. No.: HY-116282P
CAS No.: 9011-18-1
Dextran sulfate, high sulfate (MW 5000) is a type of dextran sulfate with a high degree of sulfation. Dextran sulfate sodium can be used to induce ulcerative colitis models, and the greater the total number of sulfur atoms, the stronger the induced toxic effect. Dextran sulfate has certain antibacterial activity, and can form the ionic cross-linking core of nanoparticles together with chitosan, serving as a highly efficient dressing material to accelerate wound healing .
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Cat. No.: HY-N11554
CAS No.: 26989-20-8
(-)-Codonopsine is an alkaloid with antibacterial activity. (-)-Codonopsine can be used in research related to Staphylococcus aureus and Escherichia coli infections .
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Cat. No.: HY-156100
CAS No.: 2639634-71-0
Target:  

Liposome

Research Areas:  

Others

C12-4 is an ionizable lipid for lipid nanoparticles (LNPs) formulation.
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Cat. No.: HY-160705
CAS No.: 2568616-81-7
Target:  

Liposome

Research Areas:  

Cancer

PNI 132, an ionizable lipid derived from the patent WO2020252589A, is useful in the formulation of lipid nanoparticles.
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Cat. No.: HY-W143375
CAS No.: 74563-64-7
Target:  

Bacterial

Research Areas:  

Infection

Phytantriol is an aliphatic alcohol that can be used to form nanoparticles. Phytantriol-based cubosome formulation as an antimicrobial against Lipopolysaccharides (HY-D1056) (LPS)-deficient gram-Negative bacteria .
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Cat. No.: HY-177613
CAS No.: 3031494-36-4
Synonyms: AD12115
Target:  

Kinesin

Research Areas:  

Cancer

ALN-12115 is a siRNA that targets kinesin spindle protein (KSP), and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for KSP and VEGF with potential antitumor activity.
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Cat. No.: HY-177613A
Synonyms: AD12115 sodium
Target:  

Kinesin

Research Areas:  

Cancer

ALN-12115 sodium is a siRNA that targets kinesin spindle protein (KSP), and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for KSP and VEGF with potential antitumor activity.
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Cat. No.: HY-177614
Synonyms: AD3133 sodium
Target:  

VEGFR

Research Areas:  

Cancer

ALN-3133 sodium is a siRNA that targets VEGF, and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for kinesin spindle protein (KSP) and VEGF with potential antitumor activity.
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Cat. No.: HY-171898
CAS No.: 3046404-81-0
Target:  

Liposome

Research Areas:  

Inflammation/Immunology Cancer

Lipid I97 is an ionizable lipid derived from vitamin B5 (pKa = 6.23). Lipid I97 can be used to generate lipid nanoparticles (LNPs) for mRNA delivery in vivo. Lipid I97 can be studied in research for enhancing mRNA transfection efficiency and long-term stability as well as formulation of mRNA vaccines .
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Cat. No.: HY-169801
CAS No.: 144653-57-6
Rofleponide 21-palmitate is a lipophilic Corticosteroid prodrug. Rofleponide 21-palmitate reduces subcutaneous edema, plasma haptoglobin levels, and plasma levels of IL-6, KC, IP-10, MCP-1. Rofleponide 21-palmitate increases and prolongs mRNA-encoded protein expression in lipid nanoparticle formulations .
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Cat. No.: HY-19873
CAS No.: 925438-34-2
Target:  

Photosensitizer

Research Areas:  

Cancer

SL-052 is a hypocrellin-based photosensitizer that has recently shown promising results in clinical and preclinical testing for cancer photodynamic therapy (PDT). SL-052 is encapsulated in biodegradable polylactic-co-glycolic acid (PLGA) polymer nanoparticles optimized using single emulsion solvent evaporation technology. The SL-052-PLGA nanoparticles were more effective in PDT treatment of subcutaneous SCCVII squamous cell carcinoma compared to polyvinylpyrrolidone (PVP)-based and standard liposomal SL-052 formulations. A longer time interval between drug injection and tumor illumination can improve tumor cure rates, and SL-052-PLGA nanoparticles showed the best therapeutic effect among all SL-052 formulations.
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