Antitumor agent-183
Antitumor agent-183 (compound 3f) has antitumor activity with metabolic stability. Antitumor agent-183 inhibits cancer cell growth, with IC50s less than 5 nM for A549, HCT116, and HS578T cells. The albumin-bound nanoparticle formulation of Antitumor agent-183 has prolonged retention in the tumor tissues.
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- No. CAS: 2775428-94-7
- Fòrmula: C31H18D15BrN4O9
- Peso molecular:700.61
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
<5 nM
Compound: 3f
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Antitumor activity against human A549 cells incubated for 48 hrs
Antitumor activity against human A549 cells incubated for 48 hrs
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[PMID: 39026395] |
| BMDM | IC50 |
1.42 μM
Compound: 3f
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Growth inhibition of mouse BMDMs
Growth inhibition of mouse BMDMs
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[PMID: 39026395] |
| HCT-116 | GI50 |
<5 nM
Compound: 3f
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Antitumor activity against human HCT-116 cells incubated for 48 hrs
Antitumor activity against human HCT-116 cells incubated for 48 hrs
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[PMID: 39026395] |
| Hs-578T | GI50 |
<5 nM
Compound: 3f
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Antitumor activity against human Hs-578T cells incubated for 48 hrs
Antitumor activity against human Hs-578T cells incubated for 48 hrs
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[PMID: 39026395] |
| MDA-MB-231 | GI50 |
<1 nM
Compound: 3f
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Antitumor activity against human MDA-MB-231 cells incubated for 48 hrs by Celltiter Blue reagent based 2D microtiter assay
Antitumor activity against human MDA-MB-231 cells incubated for 48 hrs by Celltiter Blue reagent based 2D microtiter assay
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[PMID: 39026395] |
| MDA-MB-231 | GI50 |
<1 nM
Compound: 3f
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Antitumor activity against human MDA-MB-231 cells incubated for 48 hrs in presence of 1.5% BSA by Celltiter Blue reagent based 2D microtiter assay
Antitumor activity against human MDA-MB-231 cells incubated for 48 hrs in presence of 1.5% BSA by Celltiter Blue reagent based 2D microtiter assay
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[PMID: 39026395] |
| MDA-MB-231 | GI50 |
2.12 nM
Compound: 3f
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Antitumor activity against human MDA-MB-231 cells incubated for 48 hrs by Celltiter Blue reagent based 3D microtiter assay
Antitumor activity against human MDA-MB-231 cells incubated for 48 hrs by Celltiter Blue reagent based 3D microtiter assay
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[PMID: 39026395] |
| MDA-MB-231 | GI50 |
9.47 nM
Compound: 3f
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Antitumor activity against human MDA-MB-231 cells incubated for 48 hrs in presence of 1.5% BSA by Celltiter Blue reagent based 3D microtiter assay
Antitumor activity against human MDA-MB-231 cells incubated for 48 hrs in presence of 1.5% BSA by Celltiter Blue reagent based 3D microtiter assay
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[PMID: 39026395] |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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No. CAS 2775428-94-7
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Unlabeled Cas 1961257-47-5
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Peso molecular 700.61
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Fòrmula C31H18D15BrN4O9
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SMILES
O=C(N[C@H]1CC(N(OC([2H])([2H])[2H])C([2H])([2H])[2H])=O)C2=CC(OC3=CC(C)=CC(C)=C3)=C(C=C2NC1=O)NC(C4=C(C(OC([2H])([2H])[2H])=C(C(OC([2H])([2H])[2H])=C4)OC([2H])([2H])[2H])Br)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-183 Related Classifications
HY-159176 Related Classifications
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