2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis Autophagy
  3. Microtubule/Tubulin Apoptosis Autophagy
  4. Nab-Paclitaxel

Nab-Paclitaxel  (Synonyms: Nanoparticle albumin-bound Paclitaxel; Nanoparticle albumin-bound ABI-007)

Cat. No.: HY-P99974 Assay: 99.9%
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Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel (HY-B0015). Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel, in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug. Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability. Nab-Paclitaxel displays less toxicity and greater antitumor activity. Nab-Paclitaxel is more readily available for tumor cell uptake in three rhabdomyosarcoma, seven neuroblastoma cell lines, and one ostersarcoma cell line Nab-Paclitaxel can be studied in cancer research for example breast cancer and solid tumors. (The product specifications below only indicate the effective content of Paditaxel, the actual albumin quality depends on the batch; the ratio of each ingredient in this product is Paditaxel: albumin -1:7~1:11).

For research use only. We do not sell to patients.

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Customer Review

Based on 4 publication(s) in Google Scholar

Nab-Paclitaxel Featured Recommendations:

Nab-Paclitaxel Related Antibodies

Top Publications Citing Use of Products

    Nab-Paclitaxel purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2024 Sep 30;23(1):215.  [Abstract]

    Sulindac K-80003 restored sensitivity to AG (10 nM, 48 h) significantly shrunk tumors arising and prolonged the median survival in the corresponding PDOX model.

    Nab-Paclitaxel purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2024 Sep 30;23(1):215.  [Abstract]

    Mice were treated with saline, the dual combination of gemcitabine (25 mg/kg, weekly), and nab-paclitaxel (15 mg/kg, weekly; red arrows), or the triple combination of gemcitabine and nab-paclitaxel (as dosed for the monotherapies) plus K-80003 (20 mg/kg, twice weekly; blue arrows) for 3 weeks. Tumors were harvest at 3 weeks after treatment. Survival curves for mice that received different treatments (5 mice per group).

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    Description

    Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel (HY-B0015). Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel, in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug. Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability. Nab-Paclitaxel displays less toxicity and greater antitumor activity. Nab-Paclitaxel is more readily available for tumor cell uptake in three rhabdomyosarcoma, seven neuroblastoma cell lines, and one ostersarcoma cell line Nab-Paclitaxel can be studied in cancer research for example breast cancer and solid tumors. (The product specifications below only indicate the effective content of Paditaxel, the actual albumin quality depends on the batch; the ratio of each ingredient in this product is Paditaxel: albumin -1:7~1:11)[1][2].

    In Vitro

    Nab-Paclitaxel (0.1 nM-10 μM, 72 h) is more readily available for tumor cell uptake in three rhabdomyosarcoma, seven neuroblastoma cell lines, and one ostersarcoma cell line[3].
    Nab-Paclitaxel (12-120 nM, 48 h) increases apoptotic RH4 cells and most cells detaches from the coveslips with higher concentration (60 or 120 nM)[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Nab-Paclitaxel Related Antibodies

    Cell Cytotoxicity Assay[3]

    Cell Line: Three rhabdomyosarcoma cell lines(RH4, RH30, and RD), seven neuroblastoma cell lines (CHLA-20, CHLA-15, CHLA-90, LAN-5, SK-N-BE(2), BE(2)C, and SH-SY5Y) and one osteosarcoma cell line (KHOS)
    Concentration: 0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM, 10 μM
    Incubation Time: 72 h
    Result: Reduced the cell viability of the three rhabdomyosarcoma cell lines with IC50 ranging from 0.56 to 4.68 nM.
    Exhibited dose-dependent cytotoxicity in seven neuroblastoma cell lines, where CHLA-20 has the highest IC50 of 36 nM.
    In Vivo

    Nab-Paclitaxel (30-50 mg/kg, i.v., administer on day 1, 8, 15) significantly inhibits RH4 tumor growth with tumor regression after second dosage on day 8 in mice bearing rhabdomyosarcoma (RH4 and RD) xenografts[3].
    Nab-Paclitaxel (2-10 mg/kg, i.v., daily) significantly inhibits tumor growth with 5 and 10 mg/kg in neuroblastoma (SK-N-BE (2) and CHLA-20) xenograft (s.c.) mice[3].
    Nab-Paclitaxel (50 mg/kg, i.v., weekly) has the strongest antitumor activity and significantly prolongs animal survival[3].
    Nab-Paclitaxel (10 mg/kg, i.v., 5 consecutive days or 50 mg/kg, i.v., weekly) displays lower plasma paclitaxel concentrations but higher intratumor paclitaxel concentrations in both rhabdomyosarcoma and neuroblastoma mice model[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female NOD/SCID (nonobese diabetic/severe combined immunodeficient) mice 4- to 6-week old bearing rhabdomyosarcoma (RH4 and RD) xenografts[3]
    Dosage: 30, 50 mg/kg
    Administration: Intravenous injection (i.v.), administer on day 1, 8, 15 then 52, 59, 66
    Result: Exhibited lower toxicity to mice compared with Paclitaxel.
    Increased local relapse-free intervals.
    Significantly inhibited tumor growth and led to tumor shrinkage.
    Remained sensitivity in mice with relapse RH4 xenografts against Nab-Paclitaxel whilst the xenografts were drug resistant against Paclitaxel.
    Led to complete regression after day 29, but a few had relapsed tumor after 37 to 42 days.
    Animal Model: Female NOD/SCID (nonobese diabetic/severe combined immunodeficient) mice 4- to 6-week old bearing rhabdomyosarcoma or neuroblastoma xenografts[3]
    Dosage: 10 mg/kg for 5 consecutive days or 50 mg/kg weekly
    Administration: Intravenous injection (i.v.)
    Result: Significantly increased apoptotic cell population in a dose-dependent manner.
    Increased phospho-histone H3-positive cells in a dose-dependent manner.
    Induced G2-M cell-cycle arrest.
    Clinical Trial
    Application

    ELISA, FACS, Functional assay
    Conjugated

    Unconjugated
    Reconsititution

    The product can be reconstituted/diluted with sterile PBS or saline.
    Molecular Weight

    853.91 Da

    Appearance

    Solid

    Color

    White to off-white

    SMILES

    [Nab-Paclitaxel]
    Formulation

    Please refer to the lot-specific COA for specific buffer information.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation

    Purity: 99.9%

    SDS (419 KB)

    COA (232 KB)

    Inhibitory Antibodies User Guide (603 KB)
    References
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    Nab-Paclitaxel Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Nab-PaclitaxelNanoparticle albumin-bound Paclitaxel Nanoparticle albumin-bound ABI-007Microtubule/TubulinApoptosisAutophagyAlbuminantitumorbreast cancerInhibitorinhibitorinhibit

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