Sodium phosphate buffer 0.1M, pH 8.0 

Sodium phosphate buffer 0.1M, pH 8.0 is an aqueous sodium phosphate buffer with a concentration of 0.1M and a pH value of 8.0. Sodium phosphate buffer 0.1M, pH 8.0 can be used for the preparation of hydrated micellar membranes, the construction of pH-sensitive nanocarriers, and the maintenance of stable environmental conditions for pH-cleavable PEG-Hz-PE micelles. Sodium phosphate buffer 0.1M, pH 8.0 can also serve as a universal solvent, reaction medium and eluent, and is widely applied in experimental processes such as antibody thiolation, nanoparticle purification and cross-linking reactions^[1][2][3].

0.1 M sodium phosphate buffer, pH 8.0 (0.1 M; 1 h) enhances the immunoreactivity of PEGylated micelles carrying the 2G4 antibody against cardiac myosin^[2].
0.1 M sodium phosphate buffer, pH 8.0 (0.1 M; 30 min+1 h) maintains the shielded state of the TATp segment on PEGylated micelles. Only weak binding between the two is observed after 30 min of pre-incubation and 1 h of co-incubation with NIH 3T3 fibroblasts^[2].
0.1M sodium phosphate buffer, pH 8.0 (0.1M; 1-24 h) supports the thiolation reaction of Trastuzumab (HY-P9907), and this reaction is accompanied by the dimerization of Trastuzumab (HY-P9907) in a time- and 2-iminothiolane concentration-dependent manner, which can be detected by size-exclusion chromatography^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Liquid

Colorless to light yellow

[Sodium phosphate buffer 0.1M, pH 8.0]

Room temperature in continental US; may vary elsewhere.

Store at room temperature, keep dry and cool

• [1]. Reshetnyak YK, et al. Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix. Proc Natl Acad Sci U S A. 2006;103(17):6460-6465.

  [2]. Sawant RM, et al. "SMART" drug delivery systems: double-targeted pH-responsive pharmaceutical nanocarriers. Bioconjug Chem. 2006;17(4):943-949.

  [3]. Steinhauser I, et al. Trastuzumab-modified nanoparticles: optimisation of preparation and uptake in cancer cells. Biomaterials. 2006;27(28):4975-4983.