Sodium phosphate buffer 0.1M, pH 8.0
Based on 1 Customer Validation
Sodium phosphate buffer 0.1M, pH 8.0 is an aqueous sodium phosphate buffer with a concentration of 0.1M and a pH value of 8.0. Sodium phosphate buffer 0.1M, pH 8.0 can be used for the preparation of hydrated micellar membranes, the construction of pH-sensitive nanocarriers, and the maintenance of stable environmental conditions for pH-cleavable PEG-Hz-PE micelles. Sodium phosphate buffer 0.1M, pH 8.0 can also serve as a universal solvent, reaction medium and eluent, and is widely applied in experimental processes such as antibody thiolation, nanoparticle purification and cross-linking reactions.
For research use only. We do not sell to patients.
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
0.1 M sodium phosphate buffer, pH 8.0 (0.1 M; 1 h) enhances the immunoreactivity of PEGylated micelles carrying the 2G4 antibody against cardiac myosin[2].
0.1 M sodium phosphate buffer, pH 8.0 (0.1 M; 30 min+1 h) maintains the shielded state of the TATp segment on PEGylated micelles. Only weak binding between the two is observed after 30 min of pre-incubation and 1 h of co-incubation with NIH 3T3 fibroblasts[2].
0.1M sodium phosphate buffer, pH 8.0 (0.1M; 1-24 h) supports the thiolation reaction of Trastuzumab (HY-P9907), and this reaction is accompanied by the dimerization of Trastuzumab (HY-P9907) in a time- and 2-iminothiolane concentration-dependent manner, which can be detected by size-exclusion chromatography[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Liquid
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Color Colorless to light yellow
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SMILES
[Sodium phosphate buffer 0.1M, pH 8.0]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Purity & Documentation
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Data Sheet (265 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Reshetnyak YK, et al. Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix. Proc Natl Acad Sci U S A. 2006;103(17):6460-6465. [Content Brief]
[2]. Sawant RM, et al. "SMART" drug delivery systems: double-targeted pH-responsive pharmaceutical nanocarriers. Bioconjug Chem. 2006;17(4):943-949. [Content Brief]
[3]. Steinhauser I, et al. Trastuzumab-modified nanoparticles: optimisation of preparation and uptake in cancer cells. Biomaterials. 2006;27(28):4975-4983. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sodium phosphate buffer 0.1M, pH 8.0 Related Classifications
HY-160113E Related Classifications
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- Sodium phosphate buffer 0.1M, pH 8.0
- Biochemical Assay Reagents
- mPEG 2000 -Hz-PE micelles
- antibody thiolation
- 2G4 antibody
- pH-sensitive nanocarrier formulations
- micelle films
- NIH 3T3 fibroblasts
- cardiac myosin
- pH-cleavable PEG-Hz-PE micelles
- nanoparticle purification
- crosslinking reactions
- Inhibitor
- inhibitor
- inhibit