1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. NT1-O12B

NT1-O12B 

Cat. No.: HY-137499
Handling Instructions

NT1-O12B, an endogenous chemical and a neurotransmitter-derived lipidoid (NT-lipidoid), is an effective carrier for enhanced brain delivery of several blood-brain barrier (BBB)-impermeable cargos. Doping NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) gives the LNPs the ability to cross the BBB. NT-lipidoids formulation not only facilitate cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination.

For research use only. We do not sell to patients.

NT1-O12B Chemical Structure

NT1-O12B Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 549 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 580 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1700 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

NT1-O12B, an endogenous chemical and a neurotransmitter-derived lipidoid (NT-lipidoid), is an effective carrier for enhanced brain delivery of several blood-brain barrier (BBB)-impermeable cargos. Doping NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) gives the LNPs the ability to cross the BBB. NT-lipidoids formulation not only facilitate cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination[1].

In Vitro

NT1-O12B indicates a lipidoid containing a tryptamine head group and a hydrophobic tail group containing 12 carbon atoms[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

It encapsulates AmB in pure NT1-lipidoids (namely NT1-O12B, NT1-O14B, NT1-O16B, and NT1-O18B) using a procedure similar to the DiR encapsulation. NT1-O12B is the dopant for enhanced brain delivery because it shows the highest DiR fluorescence intensity among all NT-lipidoids. Doping NT1-O12B to the BBB-impermeable lipidoid PBA-Q76-O16B resulted in an AmB formulation that could cross BBB. Using this approach, the AmB concentration in the brain tissue reached as high as 300 ng/g (AmB/tissue) with a delivery efficiency of about 0.135% of injected dose after 24 hours of intravenous injection with AmB (5 mg/kg)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

713.13

Formula

C₃₆H₆₀N₂O₄S₄

SMILES

CCCCCCCCSSCCOC(CCN(CCC(OCCSSCCCCCCCC)=O)CCC1=CNC2=C1C=CC=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (280.45 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4023 mL 7.0113 mL 14.0227 mL
5 mM 0.2805 mL 1.4023 mL 2.8045 mL
10 mM 0.1402 mL 0.7011 mL 1.4023 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (7.01 mM); Suspended solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 5 mg/mL (7.01 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (7.01 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

NT1-O12BEndogenous Metaboliteneurotransmitter-derivedlipidoidsbraindeliveryblood-brainbarriernervoussystemInhibitorinhibitorinhibit

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Product Name:
NT1-O12B
Cat. No.:
HY-137499
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